Article ; Online: COVID-19 pandemic effect on early pregnancy: are miscarriage rates altered, in asymptomatic women?
Archives of gynecology and obstetrics
2020 Volume 303, Issue 3, Page(s) 839–845
Abstract: ... of miscarriage.: Conclusion: The COVID-19 pandemic environment does not seem to affect early first-trimester ... Purpose: To evaluate the effect of the COVID-19 pandemic state on early, first ... in Montreal, Quebec, since the COVID-19 shut down, March 13 until May 6, 2020. Included: all women who came ...
| Abstract | Purpose: To evaluate the effect of the COVID-19 pandemic state on early, first-trimester pregnancies. Methods: A retrospective cohort study conducted at a university-affiliated fertility center in Montreal, Quebec, since the COVID-19 shut down, March 13 until May 6, 2020. Included: all women who came for a first-trimester viability scan during the study period (Study group) and between March 1, 2019 and May 17, 2019, approximately one year prior (Control). The study population denied symptoms of COVID-19. We reviewed all first trimester scans. Early first-trimester pregnancy outcomes (Viable pregnancy, arrested pregnancy including biochemical pregnancy loss and miscarriage, and ectopic pregnancy) were measured as total number and percentage. A multivariate analysis was performed to control for other potentially significant variables, as was a power analysis supporting sample size. Results: 113 women came for a first-trimester viability scan in the study period, and 172 in the control period (5-11 weeks gestational age), mean maternal age 36.5 ± 4.5 and 37.2 ± 5.4 years (p = 0.28). Viable clinical pregnancy rate was not different between the two groups (76.1 vs. 80.2% in the pandemic and pre-pandemic groups p = 0.41). No significant difference was seen in the total number of arrested pregnancies (defined as the sum of biochemical, 1st trimester miscarriages, and blighted ova) (22.1 vs. 16.9% p = 0.32), or in each type of miscarriage. Conclusion: The COVID-19 pandemic environment does not seem to affect early first-trimester miscarriage rates in asymptomatic patients. |
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| MeSH term(s) | Abortion, Spontaneous/epidemiology ; Abortion, Spontaneous/virology ; Adult ; COVID-19/blood ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/psychology ; COVID-19 Serological Testing ; Female ; Humans ; Maternal Age ; Multivariate Analysis ; Pandemics ; Pregnancy ; Pregnancy Complications, Infectious/blood ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/virology ; Pregnancy Rate ; Pregnancy Trimester, First ; Quebec ; Retrospective Studies ; SARS-CoV-2/isolation & purification |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-11-09 |
| Publishing country | Germany |
| Document type | Journal Article |
| ZDB-ID | 896455-5 |
| ISSN | 1432-0711 ; 0932-0067 |
| ISSN (online) | 1432-0711 |
| ISSN | 0932-0067 |
| DOI | 10.1007/s00404-020-05848-0 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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