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  1. Book ; Online ; E-Book: Endodontic materials in clinical practice

    Camilleri, Josette

    2021  

    Author's details edited by Josette Camilleri
    Keywords Electronic books ; Dental Pulp Diseases / therapy ; Root Canal Filling Materials / therapeutic use ; Pulp Capping and Pulpectomy Agents / therapeutic use
    Language English
    Size 1 Online-Ressource (xii, 308 Seiten), Illustrationen, Diagramme
    Publisher Wiley Blackwell
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021010320
    ISBN 978-1-119-51360-5 ; 978-1-119-51361-2 ; 9781119513520 ; 1-119-51360-X ; 1-119-51361-8 ; 1119513529
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Mechanism of action of Bioactive Endodontic Materials.

    Estrela, Carlos / Cintra, Luciano Tavares Angelo / Duarte, Marco Antônio Hungaro / Rossi-Fedele, Giampiero / Gavini, Giulio / Sousa-Neto, Manoel Damião

    Brazilian dental journal

    2023  Volume 34, Issue 1, Page(s) 1–11

    Abstract: A continuous search for bioactive materials capable of supporting the replacement of damaged pulp ... of bioactive materials (calcium hydroxide, mineral trioxide aggregate (MTA), and calcium silicate cements ... The reflective analysis of the particularities of the chemical elements of these materials, considering ...

    Abstract A continuous search for bioactive materials capable of supporting the replacement of damaged pulp tissue, with effective sealing potential and biocompatibility, has represented the attention of studies over the last decades. This study involves a narrative review of the literature developed by searching representative research in PUBMED/MEDLINE and searches in textbooks associated with the mechanism of action of bioactive materials (calcium hydroxide, mineral trioxide aggregate (MTA), and calcium silicate cements). The reflective analysis of the particularities of the chemical elements of these materials, considering the tissue and antibacterial mechanism of action, allows a better understanding of the characteristics and similarities in their tissue responses. Calcium hydroxide paste remains the antibacterial substance of choice as intracanal dressing for the treatment of root canal system infections. Calcium silicate cements, including MTA, show a favorable biological response with the stimulation of mineralized tissue deposition in sealed areas when in contact with connective tissue. This is due to the similarity between the chemical elements, especially ionic dissociation, the potential stimulation of enzymes in tissues, and the contribution towards an alkaline environment due to the pH of these materials. The behavior of bioactive materials, especially MTA and the new calcium silicate cements in the biological sealing activity, has been shown to be effective. Contemporary endodontics has access to bioactive materials with similar properties, which can stimulate a biological seal in lateral and furcation root perforations, root-end fillings and root fillings, pulp capping, pulpotomy, apexification, and regenerative endodontic procedures, in addition to other clinical conditions.
    MeSH term(s) Calcium Hydroxide/pharmacology ; Root Canal Filling Materials/pharmacology ; Root Canal Filling Materials/chemistry ; Dental Cements/chemistry ; Calcium Compounds/pharmacology ; Calcium Compounds/chemistry ; Silicates/pharmacology ; Silicates/chemistry ; Anti-Bacterial Agents/therapeutic use ; Oxides/pharmacology ; Oxides/chemistry ; Drug Combinations ; Aluminum Compounds/pharmacology ; Aluminum Compounds/chemistry
    Chemical Substances calcium silicate (S4255P4G5M) ; Calcium Hydroxide (PF5DZW74VN) ; Root Canal Filling Materials ; Dental Cements ; Calcium Compounds ; Silicates ; Anti-Bacterial Agents ; Oxides ; Drug Combinations ; Aluminum Compounds
    Language English
    Publishing date 2023-03-22
    Publishing country Brazil
    Document type Review ; Journal Article
    ZDB-ID 1089484-6
    ISSN 1806-4760 ; 0103-6440
    ISSN (online) 1806-4760
    ISSN 0103-6440
    DOI 10.1590/0103-6440202305278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3335: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: The Endodontic Space.

    Iandolo, Alfredo

    Healthcare (Basel, Switzerland)

    2023  Volume 11, Issue 4

    Abstract: Modern endodontics allows for the use of new materials and techniques in treating and saving teeth ...

    Abstract Modern endodontics allows for the use of new materials and techniques in treating and saving teeth in a simple and reproducible way [...].
    Language English
    Publishing date 2023-02-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare11040628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Advanced Materials for Clinical Endodontic Applications: Current Status and Future Directions.

    Drukteinis, Saulius / Rajasekharan, Sivaprakash / Widbiller, Matthias

    Journal of functional biomaterials

    2024  Volume 15, Issue 2

    Abstract: ... biomaterials and nanomaterials science playing a pivotal role [...]. ...

    Abstract Endodontics has significantly evolved in recent years, with advancements in instruments, biomaterials and nanomaterials science playing a pivotal role [...].
    Language English
    Publishing date 2024-01-26
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2648525-4
    ISSN 2079-4983
    ISSN 2079-4983
    DOI 10.3390/jfb15020031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Efficacy of Endodontic Disinfection Protocols in an

    Dede, Maria / Basche, Sabine / Neunzehn, Jörg / Dannemann, Martin / Hannig, Christian / Kühne, Marie-Theres

    Journal of functional biomaterials

    2023  Volume 14, Issue 4

    Abstract: The aim of this study was to investigate the antimicrobial efficacy of different disinfection protocols in a ... ...

    Abstract The aim of this study was to investigate the antimicrobial efficacy of different disinfection protocols in a novel
    Language English
    Publishing date 2023-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2648525-4
    ISSN 2079-4983
    ISSN 2079-4983
    DOI 10.3390/jfb14040176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Bioactive Endodontic Hydrogels

    Marianne Leveque / Mourad Bekhouche / Jean-Christophe Farges / Audrey Aussel / Kadiatou Sy / Raphaël Richert / Maxime Ducret

    International Journal of Molecular Sciences, Vol 24, Iss 14056, p

    From Parameters to Personalized Medicine

    2023  Volume 14056

    Abstract: Regenerative endodontic procedures (REPs) aim at recreating dental pulp tissue using biomaterials ... that compose the endodontic hydrogel. However, many other parameters, such as hydrogel concentration, bioactive ... of endodontic hydrogel is impossible to anticipate and could hinder the bench-to-bedside transition. We describe ...

    Abstract Regenerative endodontic procedures (REPs) aim at recreating dental pulp tissue using biomaterials such as hydrogels. Their bioactivity is mostly related to the nature of biomolecules or chemical compounds that compose the endodontic hydrogel. However, many other parameters, such as hydrogel concentration, bioactive molecules solubility, and apex size, were reported to influence the reciprocal host–biomaterial relationship and hydrogel behavior. The lack of knowledge regarding these various parameters, which should be considered, leads to the inability to predict the clinical outcome and suggests that the biological activity of endodontic hydrogel is impossible to anticipate and could hinder the bench-to-bedside transition. We describe, in this review, that most of these parameters could be identified, described, and studied. A second part of the review lists some challenges and perspectives, including development of future mathematical models that are able to explain, and eventually predict, the bioactivity of endodontic hydrogel used in a clinical setting.
    Keywords regenerative endodontic procedures ; hydrogels ; tissue engineering ; apical release ; preclinical model ; review ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 612
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: The response of Mesenchymal Stem Cells to endodontic materials.

    Oliveira, Patrícia Yanne de / Lacerda, Mariane Floriano Lopes Santos / Maranduba, Carlos Magno da Costa / Rettore, João Vitor Paes / Vieira, Leda Quercia / Ribeiro Sobrinho, Antônio Paulino

    Brazilian dental journal

    2022  Volume 33, Issue 2, Page(s) 33–43

    Abstract: ... in stem cells recovered from human dental pulp (hDPSCs) that were in contact with four endodontic materials ... An endodontic material must be minimally harmful to stem cells since they are essential, thanks ...

    Abstract An endodontic material must be minimally harmful to stem cells since they are essential, thanks to their capacity for cell proliferation, self-renewal, and differentiation. For this reason, in this in vitro study, the cell viability and the expression of genes involved in cell plasticity and differentiation were investigated in stem cells recovered from human dental pulp (hDPSCs) that were in contact with four endodontic materials (Endofill, MTA, Pulp Canal Sealer, and Sealer 26). The viability of HDPSCs was assessed by MTT and trypan blue exclusion assays. PCR evaluated cellular plasticity by determining the CD34, CD45, Nestin, CD105, Nanog, and OCT4 expressions. The effect on cell differentiation was determined by RT-PCR expression of the RUNX2, ALP, OC/BGLAP, and DMP1 genes. The data were analyzed using ANOVA with Bonferroni correction (p <0.05). Pulp Canal Sealer and Endofill decreased cell viability after 48 hours (p <0.001). MTA and Sealer 26 did not disrupt cell viability (p> 0.05). When cultivated in the presence of MTA and Sealer 26, hDPSCs expressed Nestin, CD105, NANOG, and OCT-4 and did not express CD34 and CD45. MTA and Sealer 26 interfered with DMP1, OC/BGLAP and RUNX2 expressions (p <0.05) but did not change ALP gene expression (p> 0.05). MTA and Sealer 26 showed biological compatibility in the presence of hDPSCs.
    MeSH term(s) Calcium Compounds/pharmacology ; Cell Differentiation ; Cells, Cultured ; Core Binding Factor Alpha 1 Subunit/metabolism ; Dental Pulp/metabolism ; Humans ; Mesenchymal Stem Cells ; Nestin/metabolism ; Pemetrexed/metabolism ; Root Canal Filling Materials ; Silicates/pharmacology
    Chemical Substances Calcium Compounds ; Core Binding Factor Alpha 1 Subunit ; Nestin ; Root Canal Filling Materials ; Silicates ; Pemetrexed (04Q9AIZ7NO)
    Language English
    Publishing date 2022-05-04
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 1089484-6
    ISSN 1806-4760 ; 0103-6440
    ISSN (online) 1806-4760
    ISSN 0103-6440
    DOI 10.1590/0103-6440202204786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3335: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Correction to: Interpreting finite element results for brittle materials in endodontic restorations.

    Pérez-González, Antonio / Iserte-Vilar, José L / González-Lluch, Carmen

    BMC surgery

    2023  Volume 23, Issue 1, Page(s) 238

    Language English
    Publishing date 2023-08-14
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2050442-1
    ISSN 1471-2482 ; 1471-2482
    ISSN (online) 1471-2482
    ISSN 1471-2482
    DOI 10.1186/s12893-023-02116-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Use of Endodontic Procedures in Young Permanent Teeth.

    Kumari, Sujata / Sharma, Ankita / Singh, Abhishek / Nagendra, Sangala Bhavani / Qurishi, Ahtesham A / Parmar, Nirav J / Mehta, Dhaval Niranjan

    Journal of pharmacy & bioallied sciences

    2024  Volume 16, Issue Suppl 1, Page(s) S797–S799

    Abstract: ... Materials and methods: A retrospective analysis was conducted on a cohort of 30 patients aged 8 to 16 years ... Background: Regenerative endodontic procedures (REPs) have emerged as a promising treatment option ...

    Abstract Background: Regenerative endodontic procedures (REPs) have emerged as a promising treatment option for young permanent teeth with pulp necrosis, offering the potential for tissue repair and preservation.
    Materials and methods: A retrospective analysis was conducted on a cohort of 30 patients aged 8 to 16 years with pulp necrosis in young permanent teeth. The patients underwent REPs, including disinfection, triple antibiotic paste application, and a coronal barrier. Clinical and radiographic data were collected at baseline and follow-up appointments at 6, 12, and 24 months. Radiographs were analyzed for root lengthening, apical closure, and resolution of periapical lesions.
    Results: The mean increase in root length after 24 months was 3.42 mm (SD ± 1.12 mm), and 90% of cases demonstrated complete apical closure. The overall success rate, defined as the absence of clinical symptoms and radiographic evidence of pathology, was 80.
    Conclusion: REPs show promising outcomes in young permanent teeth with pulp necrosis, promoting root development, and apical closure.
    Language English
    Publishing date 2024-02-29
    Publishing country India
    Document type Journal Article
    ZDB-ID 2573569-X
    ISSN 0975-7406 ; 0976-4879
    ISSN (online) 0975-7406
    ISSN 0976-4879
    DOI 10.4103/jpbs.jpbs_1018_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Exosomes as Promising Therapeutic Tools for Regenerative Endodontic Therapy.

    Kong, Qingyue / Wang, Yujie / Jiang, Nan / Wang, Yifan / Wang, Rui / Hu, Xiaohan / Mao, Jing / Shi, Xin

    Biomolecules

    2024  Volume 14, Issue 3

    Abstract: ... materials, in an attempt to lay a solid foundation for exploring and facilitating the therapeutic strategy ... of tissue engineering and regenerative medicine, research on stem cell-based regenerative endodontic therapy (RET) has ... of exosome-based regenerative endodontic procedures. ...

    Abstract Pulpitis is a common and frequent disease in dental clinics. Although vital pulp therapy and root canal treatment can stop the progression of inflammation, they do not allow for genuine structural regeneration and functional reconstruction of the pulp-dentin complex. In recent years, with the development of tissue engineering and regenerative medicine, research on stem cell-based regenerative endodontic therapy (RET) has achieved satisfactory preliminary results, significantly enhancing its clinical translational prospects. As one of the crucial paracrine effectors, the roles and functions of exosomes in pulp-dentin complex regeneration have gained considerable attention. Due to their advantages of cost-effectiveness, extensive sources, favorable biocompatibility, and high safety, exosomes are considered promising therapeutic tools to promote dental pulp regeneration. Accordingly, in this article, we first focus on the biological properties of exosomes, including their biogenesis, uptake, isolation, and characterization. Then, from the perspectives of cell proliferation, migration, odontogenesis, angiogenesis, and neurogenesis, we aim to reveal the roles and mechanisms of exosomes involved in regenerative endodontics. Lastly, immense efforts are made to illustrate the clinical strategies and influencing factors of exosomes applied in dental pulp regeneration, such as types of parental cells, culture conditions of parent cells, exosome concentrations, and scaffold materials, in an attempt to lay a solid foundation for exploring and facilitating the therapeutic strategy of exosome-based regenerative endodontic procedures.
    MeSH term(s) Regenerative Endodontics/methods ; Exosomes ; Dental Pulp ; Regeneration ; Regenerative Medicine
    Language English
    Publishing date 2024-03-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14030330
    Database MEDical Literature Analysis and Retrieval System OnLINE

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