Article ; Online: Sunitinib for the treatment of benign and malignant neoplasms from von Hippel-Lindau disease: A single-arm, prospective phase II clinical study from the PREDIR group.
Oncotarget
2016 Volume 7, Issue 51, Page(s) 85306–85317
Abstract: ... This multicenter, phase II, open-label study from the PREDIR VHL network, treated patients with genetically ... which offer an alternative treatment option for patients with VHL disease. This study investigated ... impressive transitory clinical improvement during early cycles. No patient died during sunitinib treatment ...
| Abstract | Von Hippel-Lindau (VHL) disease is an autosomal dominant hereditary cancer syndrome that predisposes affected individuals to the development of multiple benign and malignant tumors. One of the main manifestations of VHL is renal cell carcinoma (RCC). RCC is increasingly being treated with targeted therapies, which offer an alternative treatment option for patients with VHL disease. This study investigated the effectiveness of sunitinib in VHL patients with advanced tumors or tumors unsuitable for surgery.This multicenter, phase II, open-label study from the PREDIR VHL network, treated patients with genetically-confirmed advanced VHL disease with oral sunitinib (50 mg/day for 28 days then a 2-week rest period) until progression. Lesions were performed using magnetic resonance imaging (MRI) and computed tomographic (CT) scan. The primary endpoint was objective response rate; secondary endpoints included tolerability and overall survival.All five patients showed stable disease as best response at 6 months. Two patients showed impressive transitory clinical improvement during early cycles. No patient died during sunitinib treatment. Reasons for discontinuing sunitinib therapy were disease progression (n=1), unacceptable toxicity (n=3) and lack of clinical improvement after 7 cycles (10.5 months) with unacceptable toxicity (n=1).In conclusion, sunitinib was of limited benefit in patients with advanced VHL disease, but had better efficacy against metastatic RCC than other VHL-related lesions. Treatment-related toxicity is an important limiting factor in this frail patient population. New agents with different mechanisms of action are required to treat this disease. |
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| Language | English |
| Publishing date | 2016-12-20 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 1949-2553 |
| ISSN (online) | 1949-2553 |
| DOI | 10.18632/oncotarget.13301 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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