Article ; Online: SHP2 deficiency promotes Staphylococcus aureus pneumonia following influenza infection.
2019 Volume 53, Issue 1, Page(s) e12721
Abstract: ... a mouse model of post-influenza S aureus pneumonia using conditional Shp2 knockout mice (LysM: Results ... Objectives: Secondary bacterial pneumonia is common following influenza infection ... and prompts bacterial clearance in post-influenza S aureus pneumonia. ...
| Abstract | Objectives: Secondary bacterial pneumonia is common following influenza infection. However, it remains unclear about the underlying molecular mechanisms. Materials and methods: We established a mouse model of post-influenza S aureus pneumonia using conditional Shp2 knockout mice (LysM Results: LysM Conclusions: Our findings reveal that the SHP2 expression enhances the host immune response and prompts bacterial clearance in post-influenza S aureus pneumonia. |
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| MeSH term(s) | Animals ; Inflammation/genetics ; Inflammation/immunology ; Inflammation/pathology ; Influenza A virus/immunology ; Interferon Regulatory Factor-3/genetics ; Interferon Regulatory Factor-3/immunology ; Macrophages/immunology ; Macrophages/pathology ; Mice ; Mice, Transgenic ; NF-kappa B/genetics ; NF-kappa B/immunology ; Orthomyxoviridae Infections/complications ; Orthomyxoviridae Infections/genetics ; Orthomyxoviridae Infections/immunology ; Orthomyxoviridae Infections/pathology ; Pneumonia, Staphylococcal/etiology ; Pneumonia, Staphylococcal/genetics ; Pneumonia, Staphylococcal/immunology ; Pneumonia, Staphylococcal/pathology ; Protein Tyrosine Phosphatase, Non-Receptor Type 11/deficiency ; Protein Tyrosine Phosphatase, Non-Receptor Type 11/immunology ; Staphylococcus aureus/immunology | |||||
| Chemical Substances | Interferon Regulatory Factor-3 ; Irf3 protein, mouse ; NF-kappa B ; Protein Tyrosine Phosphatase, Non-Receptor Type 11 (EC 3.1.3.48) ; Ptpn11 protein, mouse (EC 3.1.3.48) | |||||
| Language | English | |||||
| Publishing date | 2019-11-29 | |||||
| Publishing country | England | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1064202-x | |||||
| ISSN | 1365-2184 ; 0008-8730 ; 0960-7722 | |||||
| ISSN (online) | 1365-2184 | |||||
| ISSN | 0008-8730 ; 0960-7722 | |||||
| DOI | 10.1111/cpr.12721 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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