Article: Incidence of lupus anticoagulant in hospitalized covid-19 patients.
American journal of blood research
2021 Volume 11, Issue 3, Page(s) 317–324
Abstract: ... the incidence of positivity of lupus anticoagulant in Covid-19 patients and analyze the association between LA ... an increased incidence of LA in Covid-19 patients, yet we didn't find any association between thrombotic events ... year. Perturbance in coagulating factors has also been reported in Covid-19 patients, including ...
| Abstract | Background: Procoagulant profile of 2019-nCoV/SARS-CoV-2 has been well documented over the last year. Perturbance in coagulating factors has also been reported in Covid-19 patients, including increased d-dimers and reports of lupus anticoagulant (LA). Methods: The current study aimed to identify the incidence of positivity of lupus anticoagulant in Covid-19 patients and analyze the association between LA and D-dimer in predicting thrombosis and mortality in one-hundred and five hospitalized adult (age >14 years) patients and forty-three hospitalized pediatric (age <14 years) patients with a confirmed diagnosis of Covid-19 between June 2020 and September 2020. Results: Twenty-one (20%) adult patients were tested positive for PTT LA, of which nine (8.6%) turned out to be confirmed positive for LA through StaClot and DRVVT Ratio tests. Six (14%) pediatric patients were positive for PTT LA, and only one (2.3%) had positive StaClot. Median D-dimer at admission was positively correlated with age and CRP among adult patients and was significantly higher in expired cases (P=0.001). No association between any of the coagulation tests and thrombosis or mortality was observed in the pediatric cohort. Conclusion: We report an increased incidence of LA in Covid-19 patients, yet we didn't find any association between thrombotic events or mortality, probably due to the small sample size. |
|---|---|
| Language | English |
| Publishing date | 2021-06-15 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2620435-6 |
| ISSN | 2160-1992 |
| ISSN | 2160-1992 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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