Article: Expression of influenza virus hemagglutinin activates transcription factor NF-kappa B.
1995 Volume 69, Issue 3, Page(s) 1480–1484
Abstract: ... of a single influenza virus protein, the virion surface hemagglutinin, strongly activates NF-kappa B DNA ... suggesting that, similar to the findings for previously described inducers of NF-kappa B, hemagglutinin ... transcription factor NF-kappa B, a central regulator of the human immune response. Here, we show that expression ...
| Abstract | Influenza virus infection initiates transcription of a variety of genes for cytokines such as tumor necrosis factor alpha (TNF-alpha), TNF-beta, interleukin 1 alpha, (IL-1 alpha), IL-1 beta, IL-2, IL-4, IL-6, IL-10, granulocyte macrophage colony-stimulating factor, and gamma interferon. However, the mechanism by which virus infection elicits cytokine expression remains unknown. Six influenza virus-induced cytokine genes are targets for the inducible transcription factor NF-kappa B, a central regulator of the human immune response. Here, we show that expression of a single influenza virus protein, the virion surface hemagglutinin, strongly activates NF-kappa B DNA binding and transactivation. Activation is inhibited in the presence of the antioxidant dithiothreitol, suggesting that, similar to the findings for previously described inducers of NF-kappa B, hemagglutinin expression generates radical oxygen intermediates which activate the transcription factor. Hemagglutinin is the first secretory and structural viral protein reported to activate NF-kappa B and thus represents a new class of inducers for this transcription factor. We discuss these results in the context of clinical complications of influenza virus infection. |
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| MeSH term(s) | Antioxidants/pharmacology ; Dithiothreitol/pharmacology ; Gene Expression Regulation, Viral/drug effects ; HeLa Cells ; Hemagglutinins, Viral/physiology ; Humans ; In Vitro Techniques ; Influenza A virus/genetics ; Influenza, Human/genetics ; NF-kappa B/physiology ; Proto-Oncogene Proteins/physiology ; RNA, Messenger/genetics ; Transcription Factor RelB ; Transcription Factors ; Transcription, Genetic | |||||
| Chemical Substances | Antioxidants ; Hemagglutinins, Viral ; NF-kappa B ; Proto-Oncogene Proteins ; RELB protein, human ; RNA, Messenger ; Transcription Factors ; Transcription Factor RelB (147337-75-5) ; Dithiothreitol (T8ID5YZU6Y) | |||||
| Language | English | |||||
| Publishing date | 1995-03 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 80174-4 | |||||
| ISSN | 1098-5514 ; 0022-538X | |||||
| ISSN (online) | 1098-5514 | |||||
| ISSN | 0022-538X | |||||
| DOI | 10.1128/JVI.69.3.1480-1484.1995 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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