Article: Dipeptidyl peptidase-4 inhibitor use and mortality in COVID-19 patients with diabetes mellitus: an updated systematic review and meta-analysis.
Therapeutic advances in endocrinology and metabolism
2021 Volume 12, Page(s) 2042018821996482
Abstract: ... of DPP4i use (preadmission or in-hospital) and mortality in COVID-19 patients with diabetes mellitus (DM ... any significant association between DPP4i use and mortality in COVID-19 patients with DM. However, on subgroup ... January 2021, to identify observational studies reporting mortality in COVID-19 patients with DM using ...
| Abstract | Background: Few observational studies have shown a beneficial effect of dipeptidyl peptidase-4 inhibitors (DPP4i) in patients with coronavirus disease 2019 (COVID-19), although results are not consistent. The present systematic review and meta-analysis was undertaken to provide a precise summary of the effect of DPP4i use (preadmission or in-hospital) and mortality in COVID-19 patients with diabetes mellitus (DM). Methods: PubMed and Google Scholar databases were systematically searched using appropriate keywords to 4 January 2021, to identify observational studies reporting mortality in COVID-19 patients with DM using DPP4i Results: We identified nine observational studies of high quality pooling data retrieved from 7008 COVID-19 patients with DM. The pooled analysis of unadjusted and adjusted data did not show any significant association between DPP4i use and mortality in COVID-19 patients with DM. However, on subgroup analysis, we found that in-hospital (and not preadmission) DPP4i use was associated with reduced mortality (unadjusted OR 0.37, 95% CI 0.23, 0.58, Conclusions: In-hospital use of DPP4i is associated with a significant reduction in COVID-19 mortality. Hence, it would be prudent to initiate or continue DPP4i in COVID-19 patients with DM if not contraindicated. |
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| Language | English |
| Publishing date | 2021-02-20 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2554822-0 |
| ISSN | 2042-0196 ; 2042-0188 |
| ISSN (online) | 2042-0196 |
| ISSN | 2042-0188 |
| DOI | 10.1177/2042018821996482 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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