Article ; Online: Impaired anti-SARS-CoV-2 antibody response in non-severe COVID-19 patients with diabetes mellitus: A preliminary report.
2020 Volume 15, Issue 1, Page(s) 193–196
Abstract: ... severe COVID-19 patients with and without type 2 diabetes mellitus (T2DM).: Methods: Records of non ... antibody response to influenza/hepatitis B vaccines. Hence, we compared anti-SARS-CoV-2 antibody response in non ... confirmation of diagnosis.: Results: Thirty-one non-severe COVID-19 patients were included. Nine patients ...
| Abstract | Background and aims: Patients with diabetes mellitus (DM) often demonstrate impaired antibody response to influenza/hepatitis B vaccines. Hence, we compared anti-SARS-CoV-2 antibody response in non-severe COVID-19 patients with and without type 2 diabetes mellitus (T2DM). Methods: Records of non-severe COVID-19 patients admitted at our institution between April 10, 2020 and May 20, 2020 were retrieved. Qualitative detection of total (IgG + IgM) anti-SARS-CoV-2 antibody was performed using electrochemiluminescence immunoassay in plasma samples collected at least 14 days post-polymerase chain reaction (PCR) confirmation of diagnosis. Results: Thirty-one non-severe COVID-19 patients were included. Nine patients (29%) had T2DM with mean HbA Conclusions: COVID-19 patients with T2DM may not undergo seroconversion even after two weeks of diagnosis. Impaired seroconversion could theoretically increase the risk of reinfections in patients with DM. However, the finding requires validation in large-scale studies involving serial estimations of anti-SARS-CoV-2 antibodies in patients with and without DM. |
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| MeSH term(s) | Adult ; Aged ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Antibody Formation/physiology ; COVID-19/blood ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19 Testing/trends ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/immunology ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2/immunology ; SARS-CoV-2/metabolism ; Young Adult |
| Chemical Substances | Antibodies, Viral |
| Language | English |
| Publishing date | 2020-12-25 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Observational Study |
| ZDB-ID | 2273766-2 |
| ISSN | 1878-0334 ; 1871-4021 |
| ISSN (online) | 1878-0334 |
| ISSN | 1871-4021 |
| DOI | 10.1016/j.dsx.2020.12.035 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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