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  1. Article ; Online: In response to: Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID-19 are associated with greater disease severity.

    Brown, Miles

    Clinical endocrinology

    2020  Volume 93, Issue 5, Page(s) 631

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Vitamin D/analogs & derivatives
    Chemical Substances Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
    Keywords covid19
    Language English
    Publishing date 2020-08-04
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 121745-8
    ISSN 1365-2265 ; 0300-0664
    ISSN (online) 1365-2265
    ISSN 0300-0664
    DOI 10.1111/cen.14285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 814: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Original publication: Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID-19 are associated with greater disease severity.

    Panagiotou, Grigorios / Tee, Su Ann / Ihsan, Yasir / Athar, Waseem / Marchitelli, Gabriella / Kelly, Donna / Boot, Christopher S / Stock, Nadia / Macfarlane, James / Martineau, Adrian R / Burns, Graham P / Quinton, Richard

    Clinical endocrinology

    2020  Volume 93, Issue 5, Page(s) 629–630

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Vitamin D/analogs & derivatives
    Chemical Substances Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
    Keywords covid19
    Language English
    Publishing date 2020-09-10
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 121745-8
    ISSN 1365-2265 ; 0300-0664
    ISSN (online) 1365-2265
    ISSN 0300-0664
    DOI 10.1111/cen.14310
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 814: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID-19 are associated with greater disease severity.

    Panagiotou, Grigorios / Tee, Su Ann / Ihsan, Yasir / Athar, Waseem / Marchitelli, Gabriella / Kelly, Donna / Boot, Christopher S / Stock, Nadia / Macfarlane, James / Martineau, Adrian R / Burns, Graham / Quinton, Richard

    Clinical endocrinology

    2020  Volume 93, Issue 4, Page(s) 508–511

    MeSH term(s) Aged ; Aged, 80 and over ; COVID-19/blood ; COVID-19/pathology ; Critical Care ; Female ; Hospitalization ; Humans ; Male ; Middle Aged ; SARS-CoV-2 ; Severity of Illness Index ; Vitamin D/analogs & derivatives ; Vitamin D/blood
    Chemical Substances Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
    Keywords covid19
    Language English
    Publishing date 2020-08-06
    Publishing country England
    Document type Letter
    ZDB-ID 121745-8
    ISSN 1365-2265 ; 0300-0664
    ISSN (online) 1365-2265
    ISSN 0300-0664
    DOI 10.1111/cen.14276
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 814: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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  4. Article: In response to: Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID-19 are associated with greater disease severity

    Brown, Miles

    Clin Endocrinol (Oxf)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #901000
    Database COVID19

    Kategorien

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  5. Article ; Online: Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID-19 are associated with greater disease severity

    Panagiotou, G / Tee, SA / Ihsan, Y / Athar, W / Marchitelli, G / Kelly, D / Boot, CS / Stock, N / Macfarlane, J / Martineau, AR / Burns, G / Quinton, R

    2020  

    Keywords covid19
    Publishing country uk
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID-19 are associated with greater disease severity

    Panagiotou, Grigorios / Tee, Su Ann / Ihsan, Yasir / Athar, Waseem / Marchitelli, Gabriella / Kelly, Donna / Boot, Christopher S / Stock, Nadia / Macfarlane, James / Martineau, Adrian R / Burns, Graham / Quinton, Richard

    Clin. endocrinol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #648988
    Database COVID19

    Kategorien

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  7. Article: Original publication: Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID-19 are associated with greater disease severity

    Panagiotou, Grigorios / Tee, Su Ann / Ihsan, Yasir / Athar, Waseem / Marchitelli, Gabriella / Kelly, Donna / Boot, Christopher S / Stock, Nadia / Macfarlane, James / Martineau, Adrian R / Burns, Graham P / Quinton, Richard

    Clin Endocrinol (Oxf)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #767198
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

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  8. Article ; Online: Low serum 25‐hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID‐19 are associated with greater disease severity

    Panagiotou, Grigorios / Tee, Su Ann / Ihsan, Yasir / Athar, Waseem / Marchitelli, Gabriella / Kelly, Donna / Boot, Christopher S. / Stock, Nadia / Macfarlane, James / Martineau, Adrian R. / Burns, Graham / Quinton, Richard

    Clinical Endocrinology

    2020  Volume 93, Issue 4, Page(s) 508–511

    Keywords Endocrinology, Diabetes and Metabolism ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 121745-8
    ISSN 1365-2265 ; 0300-0664
    ISSN (online) 1365-2265
    ISSN 0300-0664
    DOI 10.1111/cen.14276
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 814: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Low serum 25-hydroxyvitamin D (25D) levels in patients hospitalised with COVID-19 are associated with greater disease severity: results of a local audit of practice

    Panagiotou, Grigorios / Tee, Su Ann / Ihsan, Yasir / Athar, Waseem / Marchitelli, Gabriella / Kelly, Donna / Boot, Christopher S. / Stock, Nadia / Macfarlane, Jim / Martineau, Adrian R. / Burns, Graham Paul / Quinton, Richard

    Abstract: ... prevalence of VDD, and relationship of baseline serum 25(OH)D with markers of COVID-19 severity and inpatient ... respiratory rate, National Early Warning Score-2 and C-reactive protein level. While mean serum 25(OH)D levels were ... transformed-25(OH)D: 0.14, 95% Confidence Interval (CI) (-0.15, 0.41), p=0.3], only 19% of ITU patients had 25 ...

    Abstract Objectives: To audit implementation of a local protocol for the treatment of vitamin D deficiency (VDD) among patients hospitalized for Coronavirus Disease 2019 (COVID-19), including an assessment of the prevalence of VDD in these patients, and of potential associations with disease severity and fatality. Design: This was not a study or clinical trial, but rather a retrospective interim audit (Newcastle-upon-Tyne Hospitals Registration No. 10075) of a local clinical care pathway for hospitalized patients with COVID-19-related illness. The Information (Caldicott) Guardian permitted these data to be shared beyond the confines of our institution. Setting: A large tertiary academic NHS Foundation Trust in the North East of England, UK, providing care to COVID-19 patients. Participants: One hundred thirty-four hospitalized patients with documented COVID-19 infection. Main outcome measures: Adherence to local investigation and treatment protocol; prevalence of VDD, and relationship of baseline serum 25(OH)D with markers of COVID-19 severity and inpatient fatality versus recovery. Results: 55.8% of eligible patients received Colecalciferol replacement, albeit not always loaded as rapidly as our protocol suggested, and no cases of new hypercalcaemia occurred following treatment. Patients admitted to ITU were younger than those managed on medical wards (61.1 years +/- 11.8 vs. 76.4 years +/- 14.9, p<0.001), with greater prevalence of hypertension, and higher baseline respiratory rate, National Early Warning Score-2 and C-reactive protein level. While mean serum 25(OH)D levels were comparable [i.e. ITU: 33.5 nmol/L +/- 16.8 vs. Non-ITU: 48.1 nmol/L +/- 38.2, mean difference for Ln-transformed-25(OH)D: 0.14, 95% Confidence Interval (CI) (-0.15, 0.41), p=0.3], only 19% of ITU patients had 25(OH)D levels greater than 50 nmol/L vs. 39.1% of non-ITU patients (p=0.02). However, we found no association with fatality, potentially due to small sample size, limitations of no-trial data and, potentially, the prompt diagnosis and treatment of VDD. Conclusions: Subject to the inherent limitations of observational (non-trial) audit data, analysed retrospectively, we found that patients requiring ITU admission were more frequently vitamin D deficient than those managed on medical wards, despite being significantly younger. Larger prospective studies and/or clinical trials are needed to elucidate the role of vitamin D as a preventive and/or therapeutic strategy for mitigating the effects of COVID-19 infection in patients with VDD.
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    Note WHO #Covidence: #20136903
    DOI 10.1101/2020.06.21.20136903
    Database COVID19

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    Inter-library loan at ZB MED

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  10. Article ; Online: Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalised with COVID-19 are associated with greater disease severity: results of a local audit of practice.

    Panagiotou, Grigorios / Tee, Su Ann / Ihsan, Yasir / Athar, Waseem / Marchitelli, Gabriella / Kelly, Donna / Boot, Christopher S. / Stock, Nadia / Macfarlane, Jim / Martineau, Adrian R. / Burns, Graham Paul / Quinton, Richard

    medRxiv

    Abstract: ... prevalence of VDD, and relationship of baseline serum 25(OH)D with markers of COVID-19 severity and inpatient ... respiratory rate, National Early Warning Score-2 and C-reactive protein level. While mean serum 25(OH)D levels were ... transformed-25(OH)D: 0.14, 95% Confidence Interval (CI) (-0.15, 0.41), p=0.3], only 19% of ITU patients had 25 ...

    Abstract Objectives: To audit implementation of a local protocol for the treatment of vitamin D deficiency (VDD) among patients hospitalized for Coronavirus Disease 2019 (COVID-19), including an assessment of the prevalence of VDD in these patients, and of potential associations with disease severity and fatality. Design: This was not a study or clinical trial, but rather a retrospective interim audit (Newcastle-upon-Tyne Hospitals Registration No. 10075) of a local clinical care pathway for hospitalized patients with COVID-19-related illness. The Information (Caldicott) Guardian permitted these data to be shared beyond the confines of our institution. Setting: A large tertiary academic NHS Foundation Trust in the North East of England, UK, providing care to COVID-19 patients. Participants: One hundred thirty-four hospitalized patients with documented COVID-19 infection. Main outcome measures: Adherence to local investigation and treatment protocol; prevalence of VDD, and relationship of baseline serum 25(OH)D with markers of COVID-19 severity and inpatient fatality versus recovery. Results: 55.8% of eligible patients received Colecalciferol replacement, albeit not always loaded as rapidly as our protocol suggested, and no cases of new hypercalcaemia occurred following treatment. Patients admitted to ITU were younger than those managed on medical wards (61.1 years +/- 11.8 vs. 76.4 years +/- 14.9, p<0.001), with greater prevalence of hypertension, and higher baseline respiratory rate, National Early Warning Score-2 and C-reactive protein level. While mean serum 25(OH)D levels were comparable [i.e. ITU: 33.5 nmol/L +/- 16.8 vs. Non-ITU: 48.1 nmol/L +/- 38.2, mean difference for Ln-transformed-25(OH)D: 0.14, 95% Confidence Interval (CI) (-0.15, 0.41), p=0.3], only 19% of ITU patients had 25(OH)D levels greater than 50 nmol/L vs. 60.9% of non-ITU patients (p=0.02). However, we found no association with fatality, potentially due to small sample size, limitations of no-trial data and, potentially, the prompt diagnosis and treatment of VDD. Conclusions: Subject to the inherent limitations of observational (non-trial) audit data, analysed retrospectively, we found that patients requiring ITU admission were more frequently vitamin D deficient than those managed on medical wards, despite being significantly younger. Larger prospective studies and/or clinical trials are needed to elucidate the role of vitamin D as a preventive and/or therapeutic strategy for mitigating the effects of COVID-19 infection in patients with VDD.
    Keywords covid19
    Language English
    Publishing date 2020-06-23
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.06.21.20136903
    Database COVID19

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