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  1. Article: New insights into therapeutic activity and anticancer properties of curcumin.

    Panda, Abir Kumar / Chakraborty, Dwaipayan / Sarkar, Irene / Khan, Tila / Sa, Gaurisankar

    Journal of experimental pharmacology

    2017  Volume 9, Page(s) 31–45

    Abstract: ... of chemotherapeutics and simultaneously reducing their undesired side effects. Curcumin, a naturally occurring ... from the scientific community, primarily due to their ability to check and prevent the onset and progress of cancer ... These natural compounds are primarily used due to their nontoxic nature and the fewer side effects they cause ...

    Abstract Natural compounds obtained from plants are capable of garnering considerable attention from the scientific community, primarily due to their ability to check and prevent the onset and progress of cancer. These natural compounds are primarily used due to their nontoxic nature and the fewer side effects they cause compared to chemotherapeutic drugs. Furthermore, such natural products perform even better when given as an adjuvant along with traditional chemotherapeutic drugs, thereby enhancing the potential of chemotherapeutics and simultaneously reducing their undesired side effects. Curcumin, a naturally occurring polyphenol compound found in the plant
    Language English
    Publishing date 2017-03-31
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2587465-2
    ISSN 1179-1454
    ISSN 1179-1454
    DOI 10.2147/JEP.S70568
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: New mechanisms and therapeutic potential of curcumin for colorectal cancer.

    Villegas, Isabel / Sánchez-Fidalgo, Susana / Alarcón de la Lastra, Catalina

    Molecular nutrition & food research

    2008  Volume 52, Issue 9, Page(s) 1040–1061

    Abstract: ... pharmacokinetics of curcumin and describes the recently identified molecular pathways responsible of its anticancer ... Furthermore, curcumin potentiates the growth inhibitory effect of cyclo-oxygenase (COX)-2 inhibitors and ... and anti-inflammatory. More recent data provide interesting insights into the effect of this compound ...

    Abstract Curcumin is a polyphenol derived from Curcuma longa. Over the last few years, a number of studies have provided evidence of its main pharmacological properties including chemosensitizing, radiosensitizing, wound healing activities, antimicrobial, antiviral, antifungical, immunomodulatory, antioxidant and anti-inflammatory. More recent data provide interesting insights into the effect of this compound on cancer chemoprevention and chemotherapy. In fact, preclinical studies have shown its ability to inhibit carcinogenesis in various types of cancer including colorectal cancer (CRC). Curcumin has the capacity of interact with multiple molecular targets affecting the multistep process of carcinogenesis. Also, curcumin is able to arrest the cell cycle, to inhibit the inflammatory response and the oxidative stress and to induce apoptosis in cancer cells. Likewise, it has been shown to possess marked antiangiogenic properties. Furthermore, curcumin potentiates the growth inhibitory effect of cyclo-oxygenase (COX)-2 inhibitors and traditional chemotherapy agents implicating another promising therapy regimen in the future treatment of CRC. However, its clinical advance has been hindered by its short biological half-life and low bioavailability after oral administration. This review is intended to provide the reader an update of the bioavailability and pharmacokinetics of curcumin and describes the recently identified molecular pathways responsible of its anticancer potential in CRC.
    MeSH term(s) Animals ; Anticarcinogenic Agents/therapeutic use ; Antineoplastic Agents/therapeutic use ; Cell Cycle/drug effects ; Clinical Trials as Topic ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/prevention & control ; Curcumin/therapeutic use ; Disease Models, Animal ; Humans ; Mice ; Rats ; Wound Healing/drug effects
    Chemical Substances Anticarcinogenic Agents ; Antineoplastic Agents ; Curcumin (IT942ZTH98)
    Language English
    Publishing date 2008-09
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2160372-8
    ISSN 1613-4133 ; 1613-4125
    ISSN (online) 1613-4133
    ISSN 1613-4125
    DOI 10.1002/mnfr.200700280
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  3. Article: New mechanisms and therapeutic potential of curcumin for colorectal cancer

    Villegas, Isabel / Sánchez-Fidalgo, Susana / Alarcón de la Lastra, Catalina

    Molecular nutrition & food research. 2008 Sept., v. 52, no. 9

    2008  

    Abstract: ... pharmacokinetics of curcumin and describes the recently identified molecular pathways responsible of its anticancer ... Furthermore, curcumin potentiates the growth inhibitory effect of cyclo-oxygenase (COX)-2 inhibitors and ... and anti-inflammatory. More recent data provide interesting insights into the effect of this compound ...

    Abstract Curcumin is a polyphenol derived from Curcuma longa. Over the last few years, a number of studies have provided evidence of its main pharmacological properties including chemosensitizing, radiosensitizing, wound healing activities, antimicrobial, antiviral, antifungical, immunomodulatory, antioxidant and anti-inflammatory. More recent data provide interesting insights into the effect of this compound on cancer chemoprevention and chemotherapy. In fact, preclinical studies have shown its ability to inhibit carcinogenesis in various types of cancer including colorectal cancer (CRC). Curcumin has the capacity of interact with multiple molecular targets affecting the multistep process of carcinogenesis. Also, curcumin is able to arrest the cell cycle, to inhibit the inflammatory response and the oxidative stress and to induce apoptosis in cancer cells. Likewise, it has been shown to possess marked antiangiogenic properties. Furthermore, curcumin potentiates the growth inhibitory effect of cyclo-oxygenase (COX)-2 inhibitors and traditional chemotherapy agents implicating another promising therapy regimen in the future treatment of CRC. However, its clinical advance has been hindered by its short biological half-life and low bioavailability after oral administration. This review is intended to provide the reader an update of the bioavailability and pharmacokinetics of curcumin and describes the recently identified molecular pathways responsible of its anticancer potential in CRC.
    Keywords Curcuma longa ; antioxidants ; apoptosis ; bioavailability ; biological half-life ; carcinogenesis ; cell cycle ; chemoprevention ; chemotherapy ; colorectal neoplasms ; curcumin ; oral administration ; stress response ; tissue repair
    Language English
    Dates of publication 2008-09
    Size p. 1040-1061.
    Publishing place Wiley-VCH Verlag
    Document type Article
    ZDB-ID 2160372-8
    ISSN 1613-4133 ; 1613-4125
    ISSN (online) 1613-4133
    ISSN 1613-4125
    DOI 10.1002/mnfr.200700280
    Database NAL-Catalogue (AGRICOLA)

    Full text online

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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