Article: High Prevalence of SARS-CoV-2 Genetic Variation and D614G Mutation in Pediatric Patients With COVID-19.
Open forum infectious diseases
2020 Volume 8, Issue 6, Page(s) ofaa551
Abstract: ... between March 13 and June 16, 2020. Viral genetic variations across the SARS-CoV-2 genome were identified ... than expected genetic diversity, presence of the D614G mutation, increased mutation rate, and evidence ... genome sequencing was performed on respiratory specimens collected for all SARS-CoV-2-positive children (n = 141 ...
| Abstract | Background: The full spectrum of the disease phenotype and viral genotype of coronavirus disease 2019 (COVID-19) have yet to be thoroughly explored in children. Here, we analyze the relationships between viral genetic variants and clinical characteristics in children. Methods: Whole-genome sequencing was performed on respiratory specimens collected for all SARS-CoV-2-positive children (n = 141) between March 13 and June 16, 2020. Viral genetic variations across the SARS-CoV-2 genome were identified and investigated to evaluate genomic correlates of disease severity. Results: Higher viral load was detected in symptomatic patients ( Conclusions: Genomic evaluation demonstrated greater than expected genetic diversity, presence of the D614G mutation, increased mutation rate, and evidence of multiple introductions of SARS-CoV-2 into Southern California. Our findings suggest a possible association of phylogenetic clade 20C with severe disease, but small sample size precludes a definitive conclusion. Our study warrants larger and multi-institutional genomic evaluation and has implications for infection control practices. |
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| Language | English |
| Publishing date | 2020-11-13 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2757767-3 |
| ISSN | 2328-8957 |
| ISSN | 2328-8957 |
| DOI | 10.1093/ofid/ofaa551 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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