Article ; Online: Implications of atrial fibrillation on the clinical course and outcomes of hospitalized COVID-19 patients: results of the Cardio-COVID-Italy multicentre study.
2021 Volume 23, Issue 10, Page(s) 1603–1611
Abstract: ... patients with coronavirus disease 2019 (COVID-19).: Methods and results: We enrolled 696 consecutive ... after adjustment for clinical confounders related to COVID-19 severity and cardiovascular comorbidities ... not related to stroke or bleeding events.: Conclusion: Among hospitalized patients with COVID-19 ...
Abstract | Aims: To assess the clinical relevance of a history of atrial fibrillation (AF) in hospitalized patients with coronavirus disease 2019 (COVID-19). Methods and results: We enrolled 696 consecutive patients (mean age 67.4 ± 13.2 years, 69.7% males) admitted for COVID-19 in 13 Italian cardiology centres between 1 March and 9 April 2020. One hundred and six patients (15%) had a history of AF and the median hospitalization length was 14 days (interquartile range 9-24). Patients with a history of AF were older and with a higher burden of cardiovascular risk factors. Compared to patients without AF, they showed a higher rate of in-hospital death (38.7% vs. 20.8%; P < 0.001). History of AF was associated with an increased risk of death after adjustment for clinical confounders related to COVID-19 severity and cardiovascular comorbidities, including history of heart failure (HF) and increased plasma troponin [adjusted hazard ratio (HR): 1.73; 95% confidence interval (CI) 1.06-2.84; P = 0.029]. Patients with a history of AF also had more in-hospital clinical events including new-onset AF (36.8% vs. 7.9%; P < 0.001), acute HF (25.3% vs. 6.3%; P < 0.001), and multiorgan failure (13.9% vs. 5.8%; P = 0.010). The association between AF and worse outcome was not modified by previous or concomitant use of anticoagulants or steroid therapy (P for interaction >0.05 for both) and was not related to stroke or bleeding events. Conclusion: Among hospitalized patients with COVID-19, a history of AF contributes to worse clinical course with a higher mortality and in-hospital events including new-onset AF, acute HF, and multiorgan failure. The mortality risk remains significant after adjustment for variables associated with COVID-19 severity and comorbidities. |
|||||
---|---|---|---|---|---|---|
MeSH term(s) | Aged ; Aged, 80 and over ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; COVID-19 ; Female ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Hospital Mortality ; Humans ; Italy/epidemiology ; Male ; Middle Aged ; Risk Factors ; SARS-CoV-2 | |||||
Language | English | |||||
Publishing date | 2021-07-23 | |||||
Publishing country | England | |||||
Document type | Journal Article ; Multicenter Study | |||||
ZDB-ID | 1449879-0 | |||||
ISSN | 1532-2092 ; 1099-5129 | |||||
ISSN (online) | 1532-2092 | |||||
ISSN | 1099-5129 | |||||
DOI | 10.1093/europace/euab146 | |||||
Shelf mark |
|
|||||
Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
Zs.A 5434: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.