Article ; Online: CD99-dependent expansion of myeloid-derived suppressor cells and attenuation of graft-versus-host disease.
2012 Volume 33, Issue 3, Page(s) 259–267
Abstract: ... of graft-versus-host disease by regulating the expansion of myeloid-derived suppressor cells. ... the physiologic function of murine CD99. In a B6 splenocytes → bm12 graft-versus-host disease model, wild-type cells were ... of myeloid-derived suppressor cells. This was confirmed by experiments illustrating that the injection ...
| Abstract | CD99 is involved in many cellular events, such as the generation of Hodgkin and Reed-Sternberg cells, T cell costimulation, and leukocyte transendothelial migration. However, these studies have been limited to in vitro or in vivo experiments using CD99-deficient cell lines or anti-CD99 antibodies. In the present study, using CD99-deficient mice established by the exchangeable gene trap method, we investigated the physiologic function of murine CD99. In a B6 splenocytes → bm12 graft-versus-host disease model, wild-type cells were minimally lethal, whereas all mice that received CD99-deficient donor cells developed an early and more severe pathology. Graftversus-host disease in these mice was associated with insufficient expansion of myeloid-derived suppressor cells. This was confirmed by experiments illustrating that the injection of wild-type donor cells depleted of Mac-1(+) cells led to an almost identical disease course as the CD99-deficient donor system. Therefore, these results suggest that CD99 plays a crucial role in the attenuation of graft-versus-host disease by regulating the expansion of myeloid-derived suppressor cells. |
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| MeSH term(s) | 12E7 Antigen ; Animals ; Antigens, CD/genetics ; Antigens, CD/immunology ; Antigens, CD/metabolism ; Cell Movement ; Cell Proliferation ; Cell Transplantation/adverse effects ; Cytokines/blood ; Graft vs Host Disease/metabolism ; Graft vs Host Disease/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Myeloid Cells/metabolism ; Myeloid Cells/physiology ; Neoplasm Transplantation/pathology ; Spleen/immunology ; Spleen/pathology |
| Chemical Substances | 12E7 Antigen ; Antigens, CD ; Cd99 protein, mouse ; Cytokines |
| Language | English |
| Publishing date | 2012-02-15 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 1148964-9 |
| ISSN | 0219-1032 ; 1016-8478 |
| ISSN (online) | 0219-1032 |
| ISSN | 1016-8478 |
| DOI | 10.1007/s10059-012-2227-z |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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