Article ; Online: Polo-box domain: a versatile mediator of polo-like kinase function.
Cellular and molecular life sciences : CMLS
2010 Volume 67, Issue 12, Page(s) 1957–1970
Abstract: ... conserved polo-box domain (PBD) present in the C-terminal non-catalytic region of polo kinases plays ... underlying mammalian polo-like kinase 1 (Plk1)-dependent protein-protein interactions revealed that the PBD ... serves as an essential molecular mediator that brings the kinase domain of Plk1 into proximity ...
| Abstract | Members of the polo subfamily of protein kinases have emerged as important regulators in diverse aspects of the cell cycle and cell proliferation. A large body of evidence suggests that a highly conserved polo-box domain (PBD) present in the C-terminal non-catalytic region of polo kinases plays a pivotal role in the function of these enzymes. Recent advances in our comprehension of the mechanisms underlying mammalian polo-like kinase 1 (Plk1)-dependent protein-protein interactions revealed that the PBD serves as an essential molecular mediator that brings the kinase domain of Plk1 into proximity with its substrates, mainly through phospho-dependent interactions with its target proteins. In this review, current understanding of the structure and functions of PBD, mode of PBD-dependent interactions and substrate phosphorylation, and other phospho-independent functions of PBD are discussed. |
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| MeSH term(s) | Cell Cycle Proteins/chemistry ; Cell Cycle Proteins/metabolism ; Humans ; Phosphorylation ; Protein Kinases/chemistry ; Protein Kinases/metabolism ; Protein Serine-Threonine Kinases/chemistry ; Protein Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins/chemistry ; Proto-Oncogene Proteins/metabolism ; Polo-Like Kinase 1 |
| Chemical Substances | Cell Cycle Proteins ; Proto-Oncogene Proteins ; Protein Kinases (EC 2.7.-) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) |
| Language | English |
| Publishing date | 2010-02-11 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 1358415-7 |
| ISSN | 1420-9071 ; 1420-682X |
| ISSN (online) | 1420-9071 |
| ISSN | 1420-682X |
| DOI | 10.1007/s00018-010-0279-9 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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