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  1. Article ; Online: Cardiac injury is associated with severe outcome and death in patients with Coronavirus disease 2019 (COVID-19) infection: A systematic review and meta-analysis of observational studies.

    Parohan, Mohammad / Yaghoubi, Sajad / Seraji, Asal

    European heart journal. Acute cardiovascular care

    2020  Volume 9, Issue 6, Page(s) 665–677

    Abstract: ... between studies. In total, 22 studies with 3684 COVID-19 infected patients (severe cases=1095 and death ... Coronavirus disease 2019 (COVID-19) is a global pandemic impacting 213 countries/territories and ... more than 5,934,936 patients worldwide. Cardiac injury has been reported to occur in severe and death ...

    Abstract Coronavirus disease 2019 (COVID-19) is a global pandemic impacting 213 countries/territories and more than 5,934,936 patients worldwide. Cardiac injury has been reported to occur in severe and death cases. This meta-analysis was done to summarize available findings on the association between cardiac injury and severity of COVID-19 infection. Online databases including Scopus, PubMed, Web of Science, Cochrane Library and Google Scholar were searched to detect relevant publications up to 20 May 2020, using relevant keywords. To pool data, a fixed- or random-effects model was used depending on the heterogeneity between studies. In total, 22 studies with 3684 COVID-19 infected patients (severe cases=1095 and death cases=365) were included in this study. Higher serum levels of lactate dehydrogenase (weighted mean difference (WMD) =108.86 U/L, 95% confidence interval (CI)=75.93-141.79,
    MeSH term(s) Betacoronavirus ; Biomarkers/blood ; COVID-19 ; Coronavirus Infections/epidemiology ; Creatine Kinase, MB Form/blood ; Heart Diseases/etiology ; Heart Diseases/metabolism ; Humans ; Myocardium/metabolism ; Observational Studies as Topic ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Troponin I/blood
    Chemical Substances Biomarkers ; Troponin I ; Creatine Kinase, MB Form (EC 2.7.3.2)
    Keywords covid19
    Language English
    Publishing date 2020-06-21
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2663340-1
    ISSN 2048-8734 ; 2048-8726
    ISSN (online) 2048-8734
    ISSN 2048-8726
    DOI 10.1177/2048872620937165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Cardiac injury is associated with severe outcome and death in patients with Coronavirus disease 2019 (COVID-19) infection: A systematic review and meta-analysis of observational studies

    Parohan, Mohammad / Yaghoubi, Sajad / Seraji, Asal

    Eur Heart J Acute Cardiovasc Care

    Abstract: ... and myoglobin), was associated with severe outcome and death from COVID-19 infection. ... between studies. In total, 22 studies with 3684 COVID-19 infected patients (severe cases=1095 and death ... Coronavirus disease 2019 (COVID-19) is a global pandemic impacting 213 countries/territories and ...

    Abstract Coronavirus disease 2019 (COVID-19) is a global pandemic impacting 213 countries/territories and more than 5,934,936 patients worldwide. Cardiac injury has been reported to occur in severe and death cases. This meta-analysis was done to summarize available findings on the association between cardiac injury and severity of COVID-19 infection. Online databases including Scopus, PubMed, Web of Science, Cochrane Library and Google Scholar were searched to detect relevant publications up to 20 May 2020, using relevant keywords. To pool data, a fixed- or random-effects model was used depending on the heterogeneity between studies. In total, 22 studies with 3684 COVID-19 infected patients (severe cases=1095 and death cases=365) were included in this study. Higher serum levels of lactate dehydrogenase (weighted mean difference (WMD) =108.86 U/L, 95% confidence interval (CI)=75.93-141.79, p<0.001) and creatine kinase-MB (WMD=2.60 U/L, 95% CI=1.32-3.88, p<0.001) were associated with a significant increase in the severity of COVID-19 infection. Furthermore, higher serum levels of lactate dehydrogenase (WMD=213.44 U/L, 95% CI=129.97-296.92, p<0.001), cardiac troponin I (WMD=26.35 pg/mL, 95% CI=14.54-38.15, p<0.001), creatine kinase (WMD=48.10 U/L, 95% CI=0.27-95.94, p = 0.049) and myoglobin (WMD=159.77 ng/mL, 95% CI=99.54-220.01, p<0.001) were associated with a significant increase in the mortality of COVID-19 infection. Cardiac injury, as assessed by serum analysis (lactate dehydrogenase, cardiac troponin I, creatine kinase (-MB) and myoglobin), was associated with severe outcome and death from COVID-19 infection.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #610754
    Database COVID19

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  3. Article ; Online: Cardiac injury is associated with severe outcome and death in patients with Coronavirus disease 2019 (COVID-19) infection

    Parohan, Mohammad / Yaghoubi, Sajad / Seraji, Asal

    European Heart Journal: Acute Cardiovascular Care

    A systematic review and meta-analysis of observational studies

    2020  , Page(s) 204887262093716

    Abstract: ... and myoglobin), was associated with severe outcome and death from COVID-19 infection. ... between studies. In total, 22 studies with 3684 COVID-19 infected patients (severe cases=1095 and death ... Coronavirus disease 2019 (COVID-19) is a global pandemic impacting 213 countries/territories and ...

    Abstract Coronavirus disease 2019 (COVID-19) is a global pandemic impacting 213 countries/territories and more than 5,934,936 patients worldwide. Cardiac injury has been reported to occur in severe and death cases. This meta-analysis was done to summarize available findings on the association between cardiac injury and severity of COVID-19 infection. Online databases including Scopus, PubMed, Web of Science, Cochrane Library and Google Scholar were searched to detect relevant publications up to 20 May 2020, using relevant keywords. To pool data, a fixed- or random-effects model was used depending on the heterogeneity between studies. In total, 22 studies with 3684 COVID-19 infected patients (severe cases=1095 and death cases=365) were included in this study. Higher serum levels of lactate dehydrogenase (weighted mean difference (WMD) =108.86 U/L, 95% confidence interval (CI)=75.93–141.79, p<0.001) and creatine kinase-MB (WMD=2.60 U/L, 95% CI=1.32–3.88, p<0.001) were associated with a significant increase in the severity of COVID-19 infection. Furthermore, higher serum levels of lactate dehydrogenase (WMD=213.44 U/L, 95% CI=129.97–296.92, p<0.001), cardiac troponin I (WMD=26.35 pg/mL, 95% CI=14.54–38.15, p<0.001), creatine kinase (WMD=48.10 U/L, 95% CI=0.27–95.94, p = 0.049) and myoglobin (WMD=159.77 ng/mL, 95% CI=99.54–220.01, p<0.001) were associated with a significant increase in the mortality of COVID-19 infection. Cardiac injury, as assessed by serum analysis (lactate dehydrogenase, cardiac troponin I, creatine kinase (-MB) and myoglobin), was associated with severe outcome and death from COVID-19 infection.
    Keywords Critical Care and Intensive Care Medicine ; Cardiology and Cardiovascular Medicine ; General Medicine ; covid19
    Language English
    Publisher SAGE Publications
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2663340-1
    ISSN 2048-8734 ; 2048-8726
    ISSN (online) 2048-8734
    ISSN 2048-8726
    DOI 10.1177/2048872620937165
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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