Article ; Online: Multisystem Inflammatory Syndrome in Children in February 2020 and Implications of Genomic Sequencing for SARS-CoV-2.
Journal of the Pediatric Infectious Diseases Society
2020 Volume 10, Issue 5, Page(s) 695–697
Abstract: ... to be the earliest case of MIS-C, occurring in February 2020. Our patient's SARS-CoV-2 infection was ... Multisystem inflammatory syndrome in children (MIS-C) is a newly recognized disease process ... that can complicate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We present what we believe ...
| Abstract | Multisystem inflammatory syndrome in children (MIS-C) is a newly recognized disease process that can complicate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We present what we believe to be the earliest case of MIS-C, occurring in February 2020. Our patient's SARS-CoV-2 infection was caused by an emerging lineage with the D614G variant in the spike protein. This lineage would subsequently become the predominant cause of SARS-CoV-2 outbreaks in Europe and the United States where MIS-C was first described. |
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| MeSH term(s) | COVID-19/genetics ; Child ; Genome, Viral/genetics ; Humans ; Male ; Pandemics ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics ; Systemic Inflammatory Response Syndrome/genetics |
| Chemical Substances | Spike Glycoprotein, Coronavirus |
| Language | English |
| Publishing date | 2020-12-05 |
| Publishing country | England |
| Document type | Case Reports ; Journal Article |
| ZDB-ID | 2668791-4 |
| ISSN | 2048-7207 ; 2048-7193 |
| ISSN (online) | 2048-7207 |
| ISSN | 2048-7193 |
| DOI | 10.1093/jpids/piaa167 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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