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  1. Article: Serum Metabolic Profile in Patients With Long-Covid (PASC) Syndrome: Clinical Implications.

    Pasini, Evasio / Corsetti, Giovanni / Romano, Claudia / Scarabelli, Tiziano M / Chen-Scarabelli, Carol / Saravolatz, Louis / Dioguardi, Francesco S

    Frontiers in medicine

    2021  Volume 8, Page(s) 714426

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-07-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.714426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Serum Metabolic Profile in Patients With Long-Covid (PASC) Syndrome

    Evasio Pasini / Giovanni Corsetti / Claudia Romano / Tiziano M. Scarabelli / Carol Chen-Scarabelli / Louis Saravolatz / Francesco S. Dioguardi

    Frontiers in Medicine, Vol

    Clinical Implications

    2021  Volume 8

    Abstract: Background: Many patients who have been suffering by Covid-19 suffer of long-Covid syndrome ... of these patients.Methods: We studied the blood serum profile of 75 selected patients, with previous confirmed Covid ... conditions.Results: All patients had very high serum concentrations of ferritin and D-Dimer. 87 and 72 ...

    Abstract Background: Many patients who have been suffering by Covid-19 suffer of long-Covid syndrome, with symptoms of fatigue and muscular weakness that characterize post-acute sequelae SARS-CoV-2 infection (PASC). However, there is limited knowledge about the molecular pathophysiology, and about the serum profile of these patients.Methods: We studied the blood serum profile of 75 selected patients, with previous confirmed Covid-19, 2 months after hospital discharge, who reported new-onset fatigue, muscle weakness and/or dyspnea not present prior to the virus infection and independently from concomitant diseases and/or clinical conditions.Results: All patients had very high serum concentrations of ferritin and D-Dimer. 87 and 72% of patients had clinically significant low levels of hemoglobin and albumin, respectively. Seventy three percentage had elevations in erythrocyte sedimentation rate and CRP. Twenty seven percentage had elevations in LDH.Conclusions: The co-existence of patient symptoms along with blood markers of coagulation, protein disarrangement and inflammation suggests ongoing alterations in the metabolism, promoting an inflammatory/hypercatabolic state which maintains a vicious circles implicated in the persistence of PASC. The persistence of altered D-Dimer levels raises the possibility of long-term risks of thromboembolic disease. All these markers levels should be accurately evaluated in the long-term follow-up, with individualized consideration for prophylactic nutritional, anti-inflammatory and/or anticoagulant therapy if indicated.
    Keywords SARS-CoV2 ; Long-COVID-syndrome ; PASC ; ferritin ; d-dimer ; COVID-19 ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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