Article ; Online: Increasing adiposity and the presence of cardiometabolic morbidity is associated with increased Covid-19-related mortality: results from the UK Biobank.
2021 Volume 21, Issue 1, Page(s) 144
Abstract: ... cardiometabolic illness, are associated with higher odds of Covid-19-related mortality amongst the UK Biobank ... was associated with higher odds for Covid-19-related mortality. For every unit increase in BMI, WHR ... related mortality as a consequence of increasing BMI, and other more sensitive indices of adiposity ...
| Abstract | Background: Although obesity, defined by body mass index (BMI), has been associated with a higher risk of hospitalisation and more severe course of illness in Covid-19 positive patients amongst the British population, it is unclear if this translates into increased mortality. Furthermore, given that BMI is an insensitive indicator of adiposity, the effect of adipose volume on Covid-19 outcomes is also unknown. Methods: We used the UK Biobank repository, which contains clinical and anthropometric data and is linked to Public Health England Covid-19 healthcare records, to address our research question. We performed age- and sex- adjusted logistic regression and Chi-squared test to compute the odds for Covid-19-related mortality as a consequence of increasing BMI, and other more sensitive indices of adiposity such as waist:hip ratio (WHR) and percent body fat, as well as concomitant cardiometabolic illness. Results: 13,502 participants were tested for Covid-19 (mean age 70 ± 8 years, 48.9% male). 1582 tested positive (mean age 68 ± 9 years, 52.8% male), of which 305 died (mean age 75 ± 6 years, 65.5% male). Increasing adiposity was associated with higher odds for Covid-19-related mortality. For every unit increase in BMI, WHR and body fat, the odds of death amongst Covid19-positive participants increased by 1.04 (95% CI 1.01-1.07), 10.71 (95% CI 1.57-73.06) and 1.03 (95% CI 1.01-1.05), respectively (all p < 0.05). Referenced to Covid-19 positive participants with a normal weight (BMI 18.5-25 kg/m Conclusions: Anthropometric indices that are more sensitive to adipose volume and its distribution than BMI, as well as concurrent cardiometabolic illness, are associated with higher odds of Covid-19-related mortality amongst the UK Biobank cohort that tested positive for the infection. These results suggest adipose volume may contribute to adverse Covid-19-related outcomes associated with obesity. |
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| MeSH term(s) | Adiposity/physiology ; Aged ; Aged, 80 and over ; Biological Specimen Banks/statistics & numerical data ; Body Mass Index ; COVID-19/complications ; COVID-19/mortality ; COVID-19/pathology ; Cardiometabolic Risk Factors ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/mortality ; Cohort Studies ; Databases, Factual ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/mortality ; Female ; Hospital Mortality ; Humans ; Male ; Metabolic Syndrome/complications ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/mortality ; Middle Aged ; Morbidity ; Mortality ; Obesity/complications ; Obesity/epidemiology ; Obesity/mortality ; Risk Factors ; SARS-CoV-2/physiology ; United Kingdom/epidemiology |
| Language | English |
| Publishing date | 2021-07-03 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2091323-0 |
| ISSN | 1472-6823 ; 1472-6823 |
| ISSN (online) | 1472-6823 |
| ISSN | 1472-6823 |
| DOI | 10.1186/s12902-021-00805-7 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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