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  1. Article: High-density lipoproteins: the next frontier in lipid management.

    Patel, Sanjay

    The Medical journal of Australia

    2008  Volume 189, Issue 8, Page(s) 421–422

    MeSH term(s) Cholesterol Ester Transfer Proteins/physiology ; Exercise ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Life Style ; Lipoproteins, HDL/blood
    Chemical Substances Cholesterol Ester Transfer Proteins ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Lipoproteins, HDL
    Language English
    Publishing date 2008-08-05
    Publishing country Australia
    Document type Editorial
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/j.1326-5377.2008.tb02112.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: High-density lipoprotein cholesterol therapies: the next frontier in lipid management.

    Duffy, Danielle / Rader, Daniel J

    Journal of cardiopulmonary rehabilitation

    2006  Volume 26, Issue 1, Page(s) 1–8

    Abstract: ... and mortality. Thus, other lipoproteins, such as high-density lipoprotein, are now being looked ... atherosclerosis. This review details currently available strategies to raise high-density lipoprotein cholesterol ... of the complex metabolism of high-density lipoprotein. ...

    Abstract Current cholesterol treatment guidelines target low-density lipoprotein cholesterol as the primary goal of therapy and recommend statins as first line therapy. However, despite aggressive treatment and success at reaching the recommended goals, coronary heart disease is still a leading cause of morbidity and mortality. Thus, other lipoproteins, such as high-density lipoprotein, are now being looked to as the next promising targets of therapy to help reduce the burden of coronary heart disease and atherosclerosis. This review details currently available strategies to raise high-density lipoprotein cholesterol, and then turns to several new compounds in development that target the varying components of the complex metabolism of high-density lipoprotein.
    MeSH term(s) Anticholesteremic Agents/therapeutic use ; Cholesterol, HDL/blood ; Cholesterol, HDL/drug effects ; Coronary Disease/blood ; Coronary Disease/etiology ; Coronary Disease/prevention & control ; Humans ; Hypercholesterolemia/blood ; Hypercholesterolemia/complications ; Hypercholesterolemia/drug therapy ; Treatment Outcome
    Chemical Substances Anticholesteremic Agents ; Cholesterol, HDL
    Language English
    Publishing date 2006-04-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632679-1
    ISSN 0883-9212 ; 0275-1429
    ISSN 0883-9212 ; 0275-1429
    DOI 10.1097/00008483-200601000-00001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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