Article ; Online: Foxp1 controls mature B cell survival and the development of follicular and B-1 B cells.
Proceedings of the National Academy of Sciences of the United States of America
2018 Volume 115, Issue 12, Page(s) 3120–3125
Abstract: ... in developing and mature B cells results in reduced numbers and frequencies of follicular and B-1 B cells and ... deregulation of Foxp1 in B cell lymphoma, the physiological functions of Foxp1 in mature B cells remain unknown ... Here, we used conditional gene targeting in the B cell lineage and report that Foxp1 disruption ...
| Abstract | The transcription factor Foxp1 is critical for early B cell development. Despite frequent deregulation of Foxp1 in B cell lymphoma, the physiological functions of Foxp1 in mature B cells remain unknown. Here, we used conditional gene targeting in the B cell lineage and report that Foxp1 disruption in developing and mature B cells results in reduced numbers and frequencies of follicular and B-1 B cells and in impaired antibody production upon T cell-independent immunization in vivo. Moreover, |
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| MeSH term(s) | Animals ; Antibodies/metabolism ; Antigens, CD19/metabolism ; B-Lymphocytes/classification ; B-Lymphocytes/physiology ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Mice ; Mice, Knockout ; Mice, Transgenic ; Oligonucleotide Array Sequence Analysis ; Polymerase Chain Reaction ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; T-Lymphocytes/physiology ; bcl-X Protein/genetics ; bcl-X Protein/metabolism | |||||
| Chemical Substances | Antibodies ; Antigens, CD19 ; Bcl2l1 protein, mouse ; CD19 antigen, mouse ; Forkhead Transcription Factors ; Foxp1 protein, mouse ; Repressor Proteins ; bcl-X Protein | |||||
| Language | English | |||||
| Publishing date | 2018-03-05 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 209104-5 | |||||
| ISSN | 1091-6490 ; 0027-8424 | |||||
| ISSN (online) | 1091-6490 | |||||
| ISSN | 0027-8424 | |||||
| DOI | 10.1073/pnas.1711335115 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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