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  1. Article ; Online: Newborn antibodies to SARS-CoV-2 detected in cord blood after maternal vaccination - a case report.

    Paul, Gilbert / Chad, Rudnick

    BMC pediatrics

    2021  Volume 21, Issue 1, Page(s) 138

    Abstract: ... weeks prior to delivery. IgG cord blood antibodies were detected to SARS-CoV-2 at the time of birth ... Conclusion: Here, we report the first known case of an infant with SARS-CoV-2 IgG antibodies detectable ... passage of antibodies. Similar newborn protection would be expected after maternal vaccination against ...

    Abstract Background: Maternal vaccination for Influenza and Tetanus, Diphtheria, acellular Pertussis (TDaP) have been well studied in terms of safety and efficacy for protection of the newborn by placental passage of antibodies. Similar newborn protection would be expected after maternal vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). There is a significant and urgent need for research regarding safety and efficacy of vaccination against SARS-CoV-2 during pregnancy.
    Case presentation: A vigorous, healthy, full-term female was born to a COVID-19 naïve mother who had received a single dose of messenger RNA (mRNA) vaccine for SARS-CoV-2 3 weeks prior to delivery. IgG cord blood antibodies were detected to SARS-CoV-2 at the time of birth.
    Conclusion: Here, we report the first known case of an infant with SARS-CoV-2 IgG antibodies detectable in cord blood after maternal vaccination.
    MeSH term(s) Antibodies, Viral/blood ; COVID-19/prevention & control ; COVID-19 Vaccines/administration & dosage ; Female ; Fetal Blood ; Humans ; Infant, Newborn ; Pregnancy ; SARS-CoV-2/immunology
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines
    Language English
    Publishing date 2021-03-22
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2041342-7
    ISSN 1471-2431 ; 1471-2431
    ISSN (online) 1471-2431
    ISSN 1471-2431
    DOI 10.1186/s12887-021-02618-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Newborn antibodies to SARS-CoV-2 detected in cord blood after maternal vaccination

    Gilbert, Paul D / Rudnick, Chad A

    medRxiv

    Abstract: ... CoV-2 IgG antibodies detectable in cord blood after maternal vaccination. ... antibodies detectable in cord blood after maternal vaccination. Case presentation: A vigorous, healthy, full ... CoV-2 three weeks prior to delivery. Cord blood antibodies (IgG) were detected to the S-protein ...

    Abstract Background: Maternal vaccination for Influenza and TDaP have been well studied in terms of safety and efficacy for protection of the newborn by placental passage of antibodies. Similar newborn protection would be expected after maternal vaccination against SARS-CoV-2 (the virus responsible for COVID-19). There is a significant and urgent need for research regarding safety and efficacy of vaccination against SARS-CoV-2 during pregnancy. Here, we report the first known case of an infant with SARS-CoV-2 IgG antibodies detectable in cord blood after maternal vaccination. Case presentation: A vigorous, healthy, full-term female was born to a COVID-19 naive mother who had received a single dose of mRNA vaccine for SARS-CoV-2 three weeks prior to delivery. Cord blood antibodies (IgG) were detected to the S-protein of SARS-CoV-2 at time of delivery. Conclusion: Here, we report the first known case of an infant with SARS-CoV-2 IgG antibodies detectable in cord blood after maternal vaccination.
    Keywords covid19
    Language English
    Publishing date 2021-02-05
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.02.03.21250579
    Database COVID19

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  3. Article: Assessment of Neonatal Cord Blood SARS-CoV-2 Antibodies after COVID-19 Vaccination in Pregnancy: A Prospective Cohort Study

    Sourouni, Marina / Braun, Janina / Oelmeier, Kathrin / Möllers, Mareike / Willy, Daniela / Hennies, Marc T. / Köster, Helen Ann / Pecks, Ulrich / Klockenbusch, Walter / Schmitz, Ralf

    Geburtshilfe und Frauenheilkunde

    2022  Volume 82, Issue 05, Page(s) 510–516

    Abstract: ... limited data has shown transplacental transmission of antibodies after coronavirusternally derived antibodies are a key element of neonatal immunity. So far, limited data has shown transplace disease ... rtically transferred immunity after COVID-19 vaccination with BNT162b2 (ComirnatID-19) vaccination with BNT162b2 in the third trimester. Our aim was to dy, BioNTech-Pfizer) ... Introduction: Maternally derived antibodies are a key element of neonatal immunity. So far ...

    Abstract Introduction: Maternally derived antibodies are a key element of neonatal immunity. So far, limited data has shown transplacental transmission of antibodies after coronavirus disease

    2019 (COVID-19) vaccination with BNT162b2 in the third trimester. Our aim was to detect vertically transferred immunity after COVID-19 vaccination with BNT162b2 (Comirnaty, BioNTech-Pfizer)

    or mRNA-1273 (Spikevax, Moderna) in the first, second or third trimester of pregnancy, and investigate the impact of maternal characteristics on umbilical cord antibody titre in newborns

    after delivery.
    Study Design: Women who gave birth in our department and were vaccinated against COVID-19 during pregnancy were enrolled in CRONOS Satellite, a subproject of the German

    COVID-19-Related Obstetric and Neonatal Outcome Study. The titre of immunoglobulin G (IgG) antibodies to the receptor-binding domain of the SARS-CoV-2 spike protein was quantified in

    umbilical cord blood using the SARS-CoV-2 IgG II Quant immunoassay. Correlations between antibody titre and variables, including week of pregnancy when vaccinated, interval between

    vaccination and delivery, age and body mass index (BMI) were assessed with Spearmanʼs rank correlation. A follow-up was conducted by phone interview 4 – 6 weeks after delivery.
    Results: The study cohort consisted of 70 women and their 74 newborns. Vaccine-generated antibodies were present in all samples, irrespective of the vaccination type or time of

    vaccination. None of the parameters of interest showed a meaningful correlation with cord blood antibody concentrations (rho values < 0.5). No adverse outcomes (including foetal

    malformation) were reported, even after vaccination in the first trimester.
    Conclusions: Transplacental passage of SARS-CoV-2 antibodies from mother to child was demonstrated in all cases in the present study. It can therefore be assumed that the newborns of

    mothers vaccinated at any time during pregnancy receive antibodies via the placenta which potentially provide them with protection against COVID-19. This is an additional argument when

    counselling pregnant women about vaccination in pregnancy.
    Keywords SARS-CoV-2 vaccine ; pregnancy ; booster shot ; vertical immunity ; SARS-CoV-2-Impfung ; Schwangerschaft ; Auffrischimpfung ; vertikale Immunität
    Language English
    Publishing date 2022-05-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80111-2
    ISSN 1438-8804 ; 0016-5751 ; 1615-3359
    ISSN (online) 1438-8804
    ISSN 0016-5751 ; 1615-3359
    DOI 10.1055/a-1721-4908
    Database Thieme publisher's database

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