Article ; Online: Re-emergence of fatal human influenza A subtype H5N1 disease.
2004 Volume 363, Issue 9409, Page(s) 617–619
Abstract: Human disease associated with influenza A subtype H5N1 re-emerged in January, 2003, for the first ... contributes to the pathogenesis of H5N1 disease. Development of vaccines against influenza A (H5N1) virus ... MIG]). Taken together with a previous report that H5N1 influenza viruses induce large amounts ...
| Abstract | Human disease associated with influenza A subtype H5N1 re-emerged in January, 2003, for the first time since an outbreak in Hong Kong in 1997. Patients with H5N1 disease had unusually high serum concentrations of chemokines (eg, interferon induced protein-10 [IP-10] and monokine induced by interferon gamma [MIG]). Taken together with a previous report that H5N1 influenza viruses induce large amounts of proinflammatory cytokines from macrophage cultures in vitro, our findings suggest that cytokine dysfunction contributes to the pathogenesis of H5N1 disease. Development of vaccines against influenza A (H5N1) virus should be made a priority. |
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| MeSH term(s) | Animals ; China/epidemiology ; Disease Outbreaks/statistics & numerical data ; Hong Kong/epidemiology ; Humans ; Influenza A Virus, H5N1 Subtype ; Influenza A virus/isolation & purification ; Influenza in Birds/epidemiology ; Influenza in Birds/transmission ; Influenza in Birds/virology ; Influenza, Human/epidemiology ; Influenza, Human/transmission ; Influenza, Human/virology ; Poultry ; Poultry Diseases/epidemiology ; Poultry Diseases/transmission ; Zoonoses/epidemiology | ||||||||||
| Keywords | covid19 | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2004-02-20 | ||||||||||
| Publishing country | England | ||||||||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. | ||||||||||
| ZDB-ID | 3306-6 | ||||||||||
| ISSN | 1474-547X ; 0023-7507 ; 0140-6736 | ||||||||||
| ISSN (online) | 1474-547X | ||||||||||
| ISSN | 0023-7507 ; 0140-6736 | ||||||||||
| DOI | 10.1016/S0140-6736(04)15595-5 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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