Article ; Online: Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys.
Nature communications
2017 Volume 8, Issue 1, Page(s) 1493
Abstract: ... functions. We suggest that myokine-mediated muscle-kidney crosstalk can suppress metabolic reprograming and ... that the induction of a myokine, irisin, improves kidney energy metabolism and prevents kidney damage. In response ... In mice, recombinant irisin administration attenuates kidney damage and fibrosis and improves kidney ...
| Abstract | Kidney injury initiates metabolic reprogramming in tubule cells that contributes to the development of chronic kidney disease (CKD). Exercise has been associated with beneficial effects in patients with CKD. Here we show that the induction of a myokine, irisin, improves kidney energy metabolism and prevents kidney damage. In response to kidney injury, mice with muscle-specific PGC-1α overexpression (mPGC-1α) exhibit reduced kidney damage and fibrosis. Metabolomics analysis reveals increased ATP production and improved energy metabolism in injured kidneys from mPGC-1α mice. We identify irisin as a serum factor that mediates these metabolic effects during progressive kidney injury by inhibiting TGF-β type 1 receptor. Irisin depletion from serum blunts the induction of oxygen consumption rate observed in tubule cells treated with mPGC-1α serum. In mice, recombinant irisin administration attenuates kidney damage and fibrosis and improves kidney functions. We suggest that myokine-mediated muscle-kidney crosstalk can suppress metabolic reprograming and fibrogenesis during kidney disease. |
|---|---|
| MeSH term(s) | Adenosine Triphosphate/biosynthesis ; Animals ; Energy Metabolism ; Fibronectins/administration & dosage ; Fibronectins/physiology ; Fibrosis ; Kidney/pathology ; Kidney/physiology ; Kidney Tubules/metabolism ; Kidney Tubules/pathology ; Male ; Metabolomics ; Mice, Inbred C57BL ; Mice, Transgenic ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/physiology ; Oxygen Consumption ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; Physical Conditioning, Animal ; Receptors, Transforming Growth Factor beta/antagonists & inhibitors ; Receptors, Transforming Growth Factor beta/metabolism ; Recombinant Proteins/administration & dosage ; Renal Insufficiency, Chronic/metabolism ; Renal Insufficiency, Chronic/pathology ; Transforming Growth Factor beta1/metabolism |
| Chemical Substances | FNDC5 protein, mouse ; Fibronectins ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ; Ppargc1a protein, mouse ; Receptors, Transforming Growth Factor beta ; Recombinant Proteins ; Transforming Growth Factor beta1 ; Adenosine Triphosphate (8L70Q75FXE) |
| Language | English |
| Publishing date | 2017-11-14 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ISSN | 2041-1723 |
| ISSN (online) | 2041-1723 |
| DOI | 10.1038/s41467-017-01646-6 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Inter-library loan at ZB MED
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.