LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 4 of total 4

Search options

  1. Article: Influenza virus infection of the guinea pig: immune response and resistance.

    Phair, J P / Kauffman, C A / Jennings, R / Potter, C W

    Medical microbiology and immunology

    1979  Volume 165, Issue 4, Page(s) 241–254

    Abstract: ... or enhance resistance to challenge virus infection. The results do not suggest a role ... for delayed hypersensitivity response in immunity to influenza virus infection. ... Guinea pigs were inoculated by intranasal inoculation with unadapted, influenza virus A/England/42 ...

    Abstract Guinea pigs were inoculated by intranasal inoculation with unadapted, influenza virus A/England/42/72, and virus was recovered from nasal washings between 3 and 10 days post-inoculation. Infected animals did not exhibit a febrile response to infection, did not produce local antibody and produced only relatively low levels of serum antibody. However, they developed delayed-type hypersensitivity to influenza virus, demonstrable by both skin tests and macrophage migration inhibition tests, which was similar to that of man. The relevance of the influenza virus specific delayed hypersensitivity in immunity to infection was examined in this model. Guinea pigs previously infected with virus or passively immunized with hyperimmune serum were relatively resistant to reinfection with influenza virus A/England/42/72. Inoculation of guinea pigs with spleen cells from immune donor animals, together with or without immune serum, did not give or enhance resistance to challenge virus infection. The results do not suggest a role for delayed hypersensitivity response in immunity to influenza virus infection.
    MeSH term(s) Animals ; Antibodies, Viral/biosynthesis ; Cell Migration Inhibition ; Guinea Pigs ; Hypersensitivity, Delayed/immunology ; Immunity ; Immunization, Passive ; Influenza A virus/immunology ; Lymphocytes/immunology ; Macrophages/immunology ; Orthomyxoviridae Infections/immunology ; Orthomyxoviridae Infections/prevention & control ; Skin Tests
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 1979-01-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 120933-4
    ISSN 1432-1831 ; 0300-8584
    ISSN (online) 1432-1831
    ISSN 0300-8584
    DOI 10.1007/bf02152923
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Un I Zs.170: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: The innate immunity of guinea pigs against highly pathogenic avian influenza virus infection.

    Zhang, Kun / Xu, Wei Wei / Zhang, Zhaowei / Liu, Jing / Li, Jing / Sun, Lijuan / Sun, Weiyang / Jiao, Peirong / Sang, Xiaoyu / Ren, Zhiguang / Yu, Zhijun / Li, Yuanguo / Feng, Na / Wang, Tiecheng / Wang, Hualei / Yang, Songtao / Zhao, Yongkun / Zhang, Xuemei / Wilker, Peter R /
    Liu, WenJun / Liao, Ming / Chen, Hualan / Gao, Yuwei / Xia, Xianzhu

    Oncotarget

    2017  Volume 8, Issue 18, Page(s) 30422–30437

    Abstract: ... influenza virus infection of guinea pigs. This work uncovers features of the guinea pig innate immune response ... disease in response to H5N1 virus infection. Here, proteomic and transcriptional profiling were applied ... to influenza that may render guinea pigs resistant to highly pathogenic influenza viruses. ...

    Abstract H5N1 avian influenza viruses are a major pandemic concern. In contrast to the highly virulent phenotype of H5N1 in humans and many animal models, guinea pigs do not typically display signs of severe disease in response to H5N1 virus infection. Here, proteomic and transcriptional profiling were applied to identify host factors that account for the observed attenuation of A/Tiger/Harbin/01/2002 (H5N1) virulence in guinea pigs. RIG-I and numerous interferon stimulated genes were among host proteins with altered expression in guinea pig lungs during H5N1 infection. Overexpression of RIG-I or the RIG-I adaptor protein MAVS in guinea pig cell lines inhibited H5N1 replication. Endogenous GBP-1 expression was required for RIG-I mediated inhibition of viral replication upstream of the activity of MAVS. Furthermore, we show that guinea pig complement is involved in viral clearance, the regulation of inflammation, and cellular apoptosis during influenza virus infection of guinea pigs. This work uncovers features of the guinea pig innate immune response to influenza that may render guinea pigs resistant to highly pathogenic influenza viruses.
    Language English
    Publishing date 2017-05-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.16503
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Childhood viral infection and the pathogenesis of asthma and chronic obstructive lung disease.

    Hogg, J C

    American journal of respiratory and critical care medicine

    1999  Volume 160, Issue 5 Pt 2, Page(s) S26–8

    Abstract: ... of immune responses associated with allergic inflammation. Other viruses, such as adenovirus, appear to persist ... of the chronic, low-grade peripheral lung inflammation caused by adenoviral infection of guinea pigs will enable ... viral infection and the pathogenesis of asthma and chronic obstructive lung disease. ...

    Abstract Many epidemiologic studies have implicated childhood respiratory infections as an independent risk factor for the subsequent development of persistent asthma and chronic obstructive pulmonary disease (COPD). The majority of these childhood infections are viral in origin, and great strides are being made in understanding their pathogenesis at the molecular level. Some viruses, such as respiratory syncytial virus-a common cause of childhood bronchiolitis-stimulate the helper T cell type 2 (Th2) pattern of immune responses associated with allergic inflammation. Other viruses, such as adenovirus, appear to persist as latent infections in the airways of patients with COPD, and adenoviral E1A protein is capable of amplifying host genes, possibly including those involved in cigarette smoke-induced lung inflammation. Studies of the chronic, low-grade peripheral lung inflammation caused by adenoviral infection of guinea pigs will enable examination of the possibility that latent infection may induce resistance to the antiinflammatory actions of corticosteroids. Studies of the molecular mechanisms of viral infections of the airways could provide important insights into the nature of the inflammatory process involved in asthma and COPD. Hogg JC. Childhood viral infection and the pathogenesis of asthma and chronic obstructive lung disease.
    MeSH term(s) Adenovirus E1A Proteins/immunology ; Adenovirus Infections, Human/immunology ; Adenoviruses, Human/immunology ; Adult ; Animals ; Asthma/immunology ; Bronchiolitis/immunology ; Child ; Guinea Pigs ; Humans ; Lung Diseases, Obstructive/immunology ; Respiratory Syncytial Virus Infections/immunology ; Respiratory Syncytial Virus, Human/immunology ; Respiratory Tract Infections/immunology ; Smoking/adverse effects ; Th2 Cells/immunology
    Chemical Substances Adenovirus E1A Proteins
    Language English
    Publishing date 1999-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 1073-449X ; 0003-0805
    ISSN (online) 1535-4970
    ISSN 1073-449X ; 0003-0805
    DOI 10.1164/ajrccm.160.5.8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.80: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Differential alterations in host peripheral polymorphonuclear leukocyte chemiluminescence during the course of bacterial and viral infections.

    McCarthy, J P / Bodroghy, R S / Jahrling, P B / Sobocinski, P Z

    Infection and immunity

    1980  Volume 30, Issue 3, Page(s) 824–831

    Abstract: ... rats and guinea pigs as well as immune rats were inoculated with various doses (10(5) to 10(7 ... tularensis exhibited resistance to infection and a decreased PMN CL compared with nonimmune rats 24 and 48 h ... from guinea pigs inoculated with Pichinde virus failed to exhibit enhanced CL, compared with controls, despite ...

    Abstract Previous studies have shown that stimulation of the oxidative metabolism in polymorphonuclear leukocytes (PMN) by in vitro phagocytosis of various microorganisms results in photon emission, termed chemiluminescence (CL). Studies were conducted to determine whether bacterial and viral infections induce enhanced basal endogenous host peripheral PMN CL in the absence of in vitro phagocytic stimulation. Nonimmune rats and guinea pigs as well as immune rats were inoculated with various doses (10(5) to 10(7)) of live vaccine strain Francisella tularensis (per 100 g of body weight). In addition, nonimmune guinea pigs were inoculated with 40,000 plaque-forming units of Pichinde virus. Luminol-assisted endogenous PMN CL was measured at various time intervals after inoculation of microorganisms. Enhanced endogenous PMN CL was detected as early as the appearance of fever (12 h) in nonimmune animals infected with F. tularensis. Addition of sodium azide, N-ethylmaleimide, superoxide dismutase, or catalase to the CL reaction mixture containing PMN from infected animals significantly decreased the CL response. Immune rats challenged with F. tularensis exhibited resistance to infection and a decreased PMN CL compared with nonimmune rats 24 and 48 h after inoculation. However, the CL response from immune rats was significantly elevated, compared with control values. In contrast to the results obtained with the model bacterial infection, PMN isolated from guinea pigs inoculated with Pichinde virus failed to exhibit enhanced CL, compared with controls, despite significant viremia and fever. Results suggest that enhanced endogenous CL during bacterial infection occurs through mechanisms involving increased PMN oxidative metabolism and the subsequent generation of microbicidal forms of oxygen. Further, measurement of endogenous PMN CL may have diagnostic and prognostic value in infectious diseases.
    MeSH term(s) Animals ; Bacterial Infections/blood ; Guinea Pigs ; Luminescent Measurements ; Male ; Neutrophils/metabolism ; Oxygen Consumption ; Phagocytes/metabolism ; Prognosis ; Rats ; Species Specificity ; Virus Diseases/blood
    Language English
    Publishing date 1980-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/iai.30.3.824-831.1980
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 684: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top