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  1. Article: Contributions of neutrophils to the adaptive immune response in autoimmune disease.

    Pietrosimone, Kathryn M / Liu, Peng

    World journal of translational medicine

    2015  Volume 4, Issue 3, Page(s) 60–68

    Abstract: ... the adaptive immune response during chronic inflammation. In the context of the autoimmune disease, neutrophils modulating T ... Neutrophils are granulocytic cytotoxic leukocytes of the innate immune system that activate during ... this review focuses on functions of neutrophils in adaptive immunity and the therapeutic potential ...

    Abstract Neutrophils are granulocytic cytotoxic leukocytes of the innate immune system that activate during acute inflammation. Neutrophils can also persist beyond the acute phase of inflammation to impact the adaptive immune response during chronic inflammation. In the context of the autoimmune disease, neutrophils modulating T and B cell functions by producing cytokines and chemokines, forming neutrophil extracellular traps, and acting as or priming antigen presentation cells. Thus, neutrophils are actively involved in chronic inflammation and tissue damage in autoimmune disease. Using rheumatoid arthritis as an example, this review focuses on functions of neutrophils in adaptive immunity and the therapeutic potential of these cells in the treatment of autoimmune disease and chronic inflammation.
    Language English
    Publishing date 2015-12-12
    Publishing country United States
    Document type Journal Article
    ISSN 2220-6132
    ISSN 2220-6132
    DOI 10.5528/wjtm.v4.i3.60
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Monocytes contribute to DNA sensing through the TBK1 signaling pathway in type 1 diabetes patients.

    Zentsova, Irena / Parackova, Zuzana / Kayserova, Jana / Palova-Jelinkova, Lenka / Vrabcova, Petra / Volfova, Nikol / Sumnik, Zdenek / Pruhova, Stepanka / Petruzelkova, Lenka / Sediva, Anna

    Journal of autoimmunity

    2019  Volume 105, Page(s) 102294

    Abstract: Background: The aberrant recognition of self-nucleic acids by the innate immune system contributes ... to the pathology of several autoimmune diseases. Although microbial DNA and, in certain instances, self-DNA that is ... donors were stimulated with microbial DNA (CpG) or with self-DNA (DNA contained within neutrophil ...

    Abstract Background: The aberrant recognition of self-nucleic acids by the innate immune system contributes to the pathology of several autoimmune diseases. Although microbial DNA and, in certain instances, self-DNA that is released from damaged cells are primarily recognized by Toll-like receptor 9 (TLR9), recent evidence suggests that other cytosolic sequence-nonspecific DNA sensors contribute to DNA recognition. In this study, we focused on the sensing of microbial and host DNA in type 1 diabetes (T1D) patients.
    Methods: Peripheral blood mononuclear cells (PBMCs) and monocytes from pediatric patients with T1D and from healthy donors were stimulated with microbial DNA (CpG) or with self-DNA (DNA contained within neutrophil extracellular traps, NETs). The production of cytokines was measured by flow cytometry and multiplex bead assays. The internalization of microbial DNA and its colocalization with STING was detected by image cytometry. Furthermore, the involvement of the TBK1 kinase was investigated by detecting its phosphorylation with phospho-flow cytometry or by using a TBK1 inhibition assay.
    Results: We observed a prominent proinflammatory response in T1D PBMCs, especially pDCs and monocytes, to microbial DNA in comparison to that in controls. We further confirmed that monocytes could bind and internalize DNA and respond by releasing proinflammatory cytokines in a more pronounced manner in T1D patients than those in controls. Surprisingly, this cytokine production was not affected by TLR9 blockade, suggesting the involvement of intracellular receptors in DNA recognition. We further identified TBK1 and STING as two crucial molecules in the DNA-sensing pathway that were involved in CpG-DNA sensing by T1D cells. A similar DNA-sensing pathway that was dependent on intracellular DNA sensors and the STING-TBK1 interaction was employed in response to NETs, which were used to model self-DNA.
    Conclusions: Here, we show that there were significant differences in DNA sensing in T1D patients compared to that in controls. We demonstrate that monocytes from T1D patients are able to sense microbial- and self-DNA, leading to proinflammatory cytokine secretion through the adaptor protein STING and the TBK1 kinase.
    MeSH term(s) Adolescent ; Case-Control Studies ; Child ; CpG Islands/genetics ; Cytokines/metabolism ; DNA/metabolism ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/metabolism ; Female ; Humans ; Leukocytes, Mononuclear/metabolism ; Male ; Membrane Proteins/metabolism ; Monocytes/metabolism ; Protein-Serine-Threonine Kinases/metabolism ; Signal Transduction/physiology ; Toll-Like Receptor 9/metabolism
    Chemical Substances Cytokines ; Membrane Proteins ; Toll-Like Receptor 9 ; DNA (9007-49-2) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; TBK1 protein, human (EC 2.7.11.1)
    Language English
    Publishing date 2019-06-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639452-8
    ISSN 1095-9157 ; 0896-8411
    ISSN (online) 1095-9157
    ISSN 0896-8411
    DOI 10.1016/j.jaut.2019.06.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2368: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Suppression of interleukin-17 by type I interferons: a contributing factor in virus-induced immunosuppression?

    Tilg, Herbert / Moschen, Alexander R / Kaser, Arthur

    European cytokine network

    2009  Volume 20, Issue 1, Page(s) 1–6

    Abstract: ... importance for an effective anti-bacterial and anti-fungal immune response as needed subsequent ... as immunomodulatory cytokines, bridge innate and adaptive immunity. IL-17, mainly secreted by specific T cells, has ... recently been identified regulating neutrophil-mediated inflammation, and has been implicated ...

    Abstract Type I interferons (IFNs) are the first line of defence after various infections, and, as immunomodulatory cytokines, bridge innate and adaptive immunity. IL-17, mainly secreted by specific T cells, has recently been identified regulating neutrophil-mediated inflammation, and has been implicated in the pathogenesis of many acute and chronic inflammatory disorders. This cytokine is considered of critical importance for an effective anti-bacterial and anti-fungal immune response as needed subsequent to many viral infections. Recent studies have demonstrated that type I IFNs potently suppress IL-17 expression and Th17 differentiation in vitro and in vivo. Therefore, suppression of IL-17, as well as many other well-defined interactions of type I IFNs with the cytokine cascade, may contribute to virus-induced immunosuppression making the host vulnerable to bacterial and fungal attacks.
    MeSH term(s) Animals ; Cell Differentiation ; Cytokines/immunology ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Host-Pathogen Interactions/immunology ; Humans ; Immune Tolerance ; Immunity, Mucosal ; In Vitro Techniques ; Inflammation/immunology ; Inflammation/prevention & control ; Interferon Type I/immunology ; Interferon Type I/pharmacology ; Interleukin-17/antagonists & inhibitors ; Interleukin-17/biosynthesis ; Interleukin-17/immunology ; Mice ; Models, Immunological ; Recombinant Proteins ; Simian Acquired Immunodeficiency Syndrome/immunology ; Th17 Cells/cytology ; Th17 Cells/immunology ; Virus Diseases/immunology
    Chemical Substances Cytokines ; Interferon Type I ; Interleukin-17 ; Recombinant Proteins
    Language English
    Publishing date 2009-03
    Publishing country France
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1118857-1
    ISSN 1952-4005 ; 1148-5493
    ISSN (online) 1952-4005
    ISSN 1148-5493
    DOI 10.1684/ecn.2009.0141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3447: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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