Article ; Online: Euglycaemic ketoacidosis in pregnant women with COVID-19: two case reports.
BMC pregnancy and childbirth
2021 Volume 21, Issue 1, Page(s) 427
Abstract: ... presentations: We describe two cases of SARS-CoV-2 positive pregnant women presenting with normoglycaemic ... with increased susceptibility to ketosis. COVID-19 is associated with worse clinical outcomes in patients ... with diabetes and is an independent risk factor for ketoacidosis in normoglycaemic individuals.: Case ...
| Abstract | Background: Euglycaemic ketoacidosis (EKA) is an infrequent but serious condition which usually follows a period of starvation, severe vomiting or illness in individuals with or without diabetes. Ketoacidosis is associated with materno-fetal morbidity and mortality necessitating prompt diagnosis and management. Physiological increases in insulin resistance render pregnancy a diabetogenic state with increased susceptibility to ketosis. COVID-19 is associated with worse clinical outcomes in patients with diabetes and is an independent risk factor for ketoacidosis in normoglycaemic individuals. Case presentations: We describe two cases of SARS-CoV-2 positive pregnant women presenting with normoglycaemic metabolic ketoacidosis. Both cases were associated with maternal and fetal compromise, requiring aggressive fluid and insulin resuscitation and early delivery. Conclusion: We discuss possible physiology and propose a management strategy for euglycaemic ketoacidosis in pregnancy. |
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| MeSH term(s) | COVID-19/complications ; COVID-19/diagnosis ; Female ; Fluid Therapy/methods ; Humans ; Insulin Resistance ; Ketosis/complications ; Ketosis/diagnosis ; Ketosis/therapy ; Maternal-Fetal Exchange ; Pregnancy ; Pregnancy Complications/diagnosis ; Pregnancy Complications/therapy ; SARS-CoV-2 ; Starvation/complications ; Starvation/therapy |
| Language | English |
| Publishing date | 2021-06-16 |
| Publishing country | England |
| Document type | Case Reports ; Journal Article |
| ISSN | 1471-2393 |
| ISSN (online) | 1471-2393 |
| DOI | 10.1186/s12884-021-03928-w |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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