Article: Cellular spelunking: exploring adipocyte caveolae.
2007 Volume 48, Issue 10, Page(s) 2103–2111
Abstract: It has been known for decades that the adipocyte cell surface is particularly rich in small ... invaginations we now know to be caveolae. These structures are common to many cell types but are not ubiquitous ... from an "adipocentric" point of view and suggest that caveolae may have a function of particular use for the fat cell ...
| Abstract | It has been known for decades that the adipocyte cell surface is particularly rich in small invaginations we now know to be caveolae. These structures are common to many cell types but are not ubiquitous. They have generated considerable curiosity, as manifested by the numerous publications on the topic that describe various, sometimes contradictory, caveolae functions. Here, we review the field from an "adipocentric" point of view and suggest that caveolae may have a function of particular use for the fat cell, namely the modulation of fatty acid flux across the plasma membrane. Other functions for adipocyte caveolae that have been postulated include participation in signal transduction and membrane trafficking pathways, and it will require further experimental scrutiny to resolve controversies surrounding these possible activities. |
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| MeSH term(s) | Adipocytes/metabolism ; Animals ; Caveolae/metabolism ; Caveolins/metabolism ; Cell Membrane/metabolism ; Humans ; Insulin/metabolism ; Lipid Metabolism ; Models, Biological ; Phosphorylation ; Proteomics/methods ; Rats ; Signal Transduction ; Tyrosine/metabolism |
| Chemical Substances | Caveolins ; Insulin ; Tyrosine (42HK56048U) |
| Language | English |
| Publishing date | 2007-05-11 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Review |
| ZDB-ID | 80154-9 |
| ISSN | 1539-7262 ; 0022-2275 |
| ISSN (online) | 1539-7262 |
| ISSN | 0022-2275 |
| DOI | 10.1194/jlr.R700009-JLR200 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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