Article ; Online: SARS-CoV-2 re-infection risk in Austria.
European journal of clinical investigation
2021 Volume 51, Issue 4, Page(s) e13520
Abstract: ... with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We aimed to evaluate the risk of SARS-CoV-2 re-infections ... CoV-2 in Austria. Protection against SARS-CoV-2 after natural infection is comparable with the highest ... in the general population in Austria.: Methods: This is a retrospective observational study using national SARS-CoV-2 ...
| Abstract | Background: A key question concerning coronavirus disease 2019 (COVID-19) is how effective and long lasting immunity against this disease is in individuals who were previously infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We aimed to evaluate the risk of SARS-CoV-2 re-infections in the general population in Austria. Methods: This is a retrospective observational study using national SARS-CoV-2 infection data from the Austrian epidemiological reporting system. As the primary outcome, we aim to compare the odds of SARS-CoV-2 re-infections of COVID-19 survivors of the first wave (February to April 30, 2020) versus the odds of first infections in the remainder general population by tracking polymerase chain reaction (PCR)-confirmed infections of both groups during the second wave from September 1 to November 30, 2020. Re-infection counts are tentative, since it cannot be excluded that the positive PCR in the first and/or second wave might have been a false positive. Results: We recorded 40 tentative re-infections in 14 840 COVID-19 survivors of the first wave (0.27%) and 253 581 infections in 8 885 640 individuals of the remaining general population (2.85%) translating into an odds ratio (95% confidence interval) of 0.09 (0.07 to 0.13). Conclusions: We observed a relatively low re-infection rate of SARS-CoV-2 in Austria. Protection against SARS-CoV-2 after natural infection is comparable with the highest available estimates on vaccine efficacies. Further well-designed research on this issue is urgently needed for improving evidence-based decisions on public health measures and vaccination strategies. |
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| MeSH term(s) | Adolescent ; Adult ; Aged ; Aged, 80 and over ; Austria/epidemiology ; COVID-19/epidemiology ; COVID-19 Nucleic Acid Testing ; Female ; Humans ; Male ; Middle Aged ; Reinfection/epidemiology ; Retrospective Studies ; SARS-CoV-2 ; Young Adult |
| Language | English |
| Publishing date | 2021-02-21 |
| Publishing country | England |
| Document type | Journal Article ; Observational Study |
| ZDB-ID | 186196-7 |
| ISSN | 1365-2362 ; 0014-2972 ; 0960-135X |
| ISSN (online) | 1365-2362 |
| ISSN | 0014-2972 ; 0960-135X |
| DOI | 10.1111/eci.13520 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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