Article ; Online: Pulmonary delivery of nanostructured lipid carriers for effective repurposing of salinomycin as an antiviral agent.
2020 Volume 143, Page(s) 109858
Abstract: ... In this hypothesis, we discuss the potential of pulmonary delivery of SAL using nanostructured lipid carriers (NLCs ... viral infections. Recent drug screen identified SAL as a potent antiviral agent against SARS-CoV-2 ... Coronavirus disease outbreak caused a severe public health burden all over the world. Salinomycin ...
| Abstract | Coronavirus disease outbreak caused a severe public health burden all over the world. Salinomycin (SAL) is a broad-spectrum antibiotic that had drawn attention in selective targeting of cancer and viral infections. Recent drug screen identified SAL as a potent antiviral agent against SARS-CoV-2. In this hypothesis, we discuss the potential of pulmonary delivery of SAL using nanostructured lipid carriers (NLCs) against SARS-CoV-2. |
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| MeSH term(s) | Antiviral Agents/administration & dosage ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; Drug Carriers ; Drug Repositioning ; Endocytosis ; Humans ; Lipids/chemistry ; Lung/drug effects ; Nanostructures/chemistry ; Pandemics ; Pneumonia, Viral/drug therapy ; Pyrans/administration & dosage ; RNA, Viral ; SARS-CoV-2 ; COVID-19 Drug Treatment |
| Chemical Substances | Antiviral Agents ; Drug Carriers ; Lipids ; Pyrans ; RNA, Viral ; salinomycin (62UXS86T64) |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-05-30 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 193145-3 |
| ISSN | 1532-2777 ; 0306-9877 |
| ISSN (online) | 1532-2777 |
| ISSN | 0306-9877 |
| DOI | 10.1016/j.mehy.2020.109858 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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