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  1. Article: Risk factors and outcomes for acute respiratory failure in coronavirus disease 2019: An observational cohort study.

    Piwowarczyk, Paweł / Szczukocka, Marta / Kutnik, Paweł / Borys, Michał / Mikłaszewska, Anna / Kiciak, Sławomir / Czuczwar, Mirosław

    Advances in clinical and experimental medicine : official organ Wroclaw Medical University

    2020  Volume 30, Issue 2, Page(s) 165–171

    Abstract: ... in Europe, especially in the population that developed acute respiratory failure (ARF).: Objectives ... Background: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread ... To identify risk factors associated with developing ARF during SARS-CoV-2 infection.: Material and methods ...

    Abstract Background: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread throughout Europe. However, there is a lack of data on the full clinical course of patients infected with SARS-CoV-2 in Europe, especially in the population that developed acute respiratory failure (ARF).
    Objectives: To identify risk factors associated with developing ARF during SARS-CoV-2 infection.
    Material and methods: This was an observational study of 60 adult patients with laboratory-confirmed SARS-CoV-2 infection. Data were collected from March 26, 2020 to May 26, 2020 in a tertiary academic hospital in Poland. All patients reached final outcome (discharge from the hospital or death). We divided patients into 2 groups based on whether they developed ARF, compared their clinical data, and performed multivariate logistic regression.
    Results: Twenty-two patients (36%) from the observed cohort developed ARF. Logistic regression identified that a high sequential organ failure assessment score at admission (odds ratio (OR) = 6.97 (1.57-30.90, p = 0.011)), and a long time from admission until pneumonia (OR = 1.41 (1.06-1.87, p = 0.016)), correlated with ARF development. D-dimer, lactate dehydrogenase, neutrophil to lymphocyte ratio, C-reactive protein (CRP), and interleukin 6 (IL-6) differed both statistically and clinically between ARF and non-ARF groups. The mortality rate in the observed cohort of patients was 13.3%, and it was 32% in the group that developed ARF.
    Conclusions: Routine vigilant examination of the above markers may identify patients at the highest risk of ARF early on during COVID-19 infection.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Aged ; COVID-19/complications ; COVID-19/mortality ; Cohort Studies ; Europe ; Humans ; Middle Aged ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/therapy ; Risk Factors ; SARS-CoV-2 ; Sex Factors ; Treatment Outcome
    Language English
    Publishing date 2020-12-31
    Publishing country Poland
    Document type Journal Article ; Observational Study
    ZDB-ID 2270257-X
    ISSN 1899-5276 ; 1230-025X
    ISSN 1899-5276 ; 1230-025X
    DOI 10.17219/acem/130603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6489: Show issues Location:
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  2. Article ; Online: Arterial lactate as a risk factor for death in respiratory failure related to coronavirus disease 2019: an observational study.

    Maraziti, Giorgio / Marchini, Laura / Barbieri, Greta / Falcone, Marco / Corradi, Francesco / Graziani, Mara / Ghiadoni, Lorenzo / Becattini, Cecilia

    Therapeutic advances in respiratory disease

    2023  Volume 17, Page(s) 17534666231186730

    Abstract: ... patients. The prognostic role of arterial lactate in acute respiratory failure due to the novel coronavirus ... of arterial lactate levels at admission in patients with COVID-19-related acute respiratory failure.: Design ... with acute respiratory failure related to COVID-19. ...

    Abstract Background: Arterial lactate is a recognized biomarker associated with death in critically ill patients. The prognostic role of arterial lactate in acute respiratory failure due to the novel coronavirus disease 2019 (COVID-19) is unclear.
    Objectives: We aimed to investigate the prognostic role of arterial lactate levels at admission in patients with COVID-19-related acute respiratory failure.
    Design and methods: Cohorts of consecutive patients admitted to nonintensive care units (ICU) at study centers for COVID-19-related respiratory failure were merged into a collaborative database. The prognostic role of lactate levels at admission was assessed for continuous values and values ⩾2.0 mmol/l, and lactate clearance at 24 h through delta-lactate (ΔLac). The study outcome was 30-day in-hospital death. Cox proportional regression model was used to assess independent predictors of the study outcome.
    Results: At admission, 14.6% of patients had lactate levels ⩾2 mmol/l. In-hospital death at 30 days occurred in 57 out of 206 patients; 22.3% and 56.7% with normal or ⩾ 2 mmol/l lactate at admission, respectively. The median lactate level was 1.0 [interquartile range (IQR) 0.8-1.3] mmol/l and 1.3 (IQR 1.0-2.1) mmol/l in survivors and nonsurvivors, respectively (
    Conclusions: In our study, increased arterial lactate at admission was independently associated with in-hospital death at 30 days in non-ICU patients with acute respiratory failure related to COVID-19.
    MeSH term(s) Humans ; COVID-19/complications ; Lactic Acid ; Hospital Mortality ; Respiratory Insufficiency/etiology ; Respiratory Distress Syndrome ; Intensive Care Units ; Risk Factors ; Retrospective Studies
    Chemical Substances Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2023-08-30
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2476459-0
    ISSN 1753-4666 ; 1753-4658
    ISSN (online) 1753-4666
    ISSN 1753-4658
    DOI 10.1177/17534666231186730
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6753: Show issues Location:
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  3. Article ; Online: Risk factors and outcomes for acute-on-chronic liver failure in COVID-19: a large multi-center observational cohort study.

    Satapathy, Sanjaya K / Roth, Nitzan C / Kvasnovsky, Charlotte / Hirsch, Jamie S / Trindade, Arvind J / Molmenti, Ernesto / Barish, Matthew / Hirschwerk, David / Da, Ben L / Bernstein, David

    Hepatology international

    2021  Volume 15, Issue 3, Page(s) 766–779

    Abstract: Objective: Coronavirus disease 2019 [COVID-19] infection in patients with chronic liver disease ... developed ACLF, with respiratory failure [39%] and renal failure [26%] being the most common. Hispanic ... CLD] may precipitate acute-on-chronic liver failure [ACLF]. In a large multi-center cohort of COVID-19 ...

    Abstract Objective: Coronavirus disease 2019 [COVID-19] infection in patients with chronic liver disease [CLD] may precipitate acute-on-chronic liver failure [ACLF]. In a large multi-center cohort of COVID-19-infected patients, we aim to analyze (1) the outcomes of patients with underlying CLD [with and without cirrhosis] and (2) the development and impact of ACLF on in-hospital mortality.
    Design: We identified 192 adults with CLD from among 10,859 patients with confirmed COVID-19 infection (admitted to any of 12 hospitals in a New York health care system between March 1, 2020 and April 27, 2020). ACLF was defined using the EASL-CLIF Consortium definition. Patient follow-up was through April 30, 2020, or until the date of discharge, transfer, or death.
    Results: Of the 84 patients with cirrhosis, 32 [38%] developed ACLF, with respiratory failure [39%] and renal failure [26%] being the most common. Hispanic/Latino ethnicity was particularly at higher risk of in-hospital mortality [adjusted HR 4.92, 95% 1.27-19.09, p < 0.02] in cirrhosis despite having lower risk of development of ACLF [HR 0.26, 95% CI 0.08-0.89, p = 0.03]. Hypertension on admission predicted development of ACLF [HR 3.46, 95% CI 1.12-10.75, p = 0.03]. In-hospital mortality was not different between CLD patients with or without cirrhosis [p = 0.24] but was higher in those with cirrhosis who developed ACLF [adjusted HR 9.06, 95% CI 2.63-31.12, p < 0.001] with a trend for increased mortality by grade of ACLF [p = 0.002]. There was no difference in in-hospital mortality between the CLD cohort compared to matched control without CLD (log rank, p = 0.98) and between the cirrhosis cohort compared to matched control without cirrhosis (log rank, p = 0.51).
    Conclusion: Development of ACLF is the main driver of increased in-hospital mortality in hospitalized patients with COVID-19 infection and cirrhosis.
    Language English
    Publishing date 2021-04-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2270316-0
    ISSN 1936-0541 ; 1936-0533
    ISSN (online) 1936-0541
    ISSN 1936-0533
    DOI 10.1007/s12072-021-10181-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A retrospective cohort study of risk factors and outcomes in older patients admitted to an inner-city geriatric unit in London during first peak of COVID-19 pandemic.

    Maniero, Carmela / Patel, Devan / Pavithran, Asha / Naran, Prasheena / Ng, Fu Liang / Prowle, John / Sivapathasuntharam, Dhanupriya

    Irish journal of medical science

    2021  Volume 191, Issue 3, Page(s) 1037–1045

    Abstract: ... chronic kidney disease, as well as those diagnosed with respiratory failure, acute kidney injury or hypernatremia ... Purpose: Compared to younger patients, coronavirus disease 2019 (COVID-19) clinical presentation ... Independent predictors of mortality were male sex, age > 80 years, respiratory failure and hypernatremia ...

    Abstract Purpose: Compared to younger patients, coronavirus disease 2019 (COVID-19) clinical presentation in older people can be more heterogeneous and fatal. We aim to describe a cohort of older adults admitted in an inner-city London hospital during the first peak of the pandemic.
    Methods: A retrospective observational study that enrolled older adults consecutively admitted into two geriatric wards with suspected or confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We collected socio-demographic data, comorbidities, symptoms at presentation and/or during admission, biochemical and radiological data and outcomes at 28 days.
    Results: One hundred twenty-four patients were included, and 75% were > 80 years old. 19.5% of COVID-19 cases were judged to be hospital-acquired. More than half presented or developed typical symptoms, respiratory failure or fatigue. 46.8% were diagnosed with delirium, 24.2% with falls and dysphagia was present in 13.7%. The mortality rate was 29.8% and was higher among males, those > 80 years, patients with a higher grade of frailty, a history of dementia or chronic kidney disease, as well as those diagnosed with respiratory failure, acute kidney injury or hypernatremia. Independent predictors of mortality were male sex, age > 80 years, respiratory failure and hypernatremia.
    Conclusion: We have described a cohort of patients with SARS-CoV-2 infection in the first UK peak of the global pandemic. We found that these patients had significant frailty with multiple comorbidities. There was a high mortality and increased dependency and greater social care need in survivors.
    MeSH term(s) Aged ; Aged, 80 and over ; COVID-19/epidemiology ; Female ; Frailty/epidemiology ; Hospitals, Urban ; Humans ; Hypernatremia ; London/epidemiology ; Male ; Pandemics ; Respiratory Insufficiency ; Retrospective Studies ; Risk Factors ; SARS-CoV-2
    Language English
    Publishing date 2021-07-06
    Publishing country Ireland
    Document type Journal Article ; Observational Study
    ZDB-ID 390895-1
    ISSN 1863-4362 ; 0021-1265
    ISSN (online) 1863-4362
    ISSN 0021-1265
    DOI 10.1007/s11845-021-02679-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 323: Show issues Location:
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