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  1. Article ; Online: Undifferentiated primate spermatogonia and their endocrine control.

    Plant, Tony M

    Trends in endocrinology and metabolism: TEM

    2010  Volume 21, Issue 8, Page(s) 488–495

    Abstract: ... respectively, are critically evaluated and essential features of endocrine control of undifferentiated ... to the classic view of dark and pale type A spermatogonia as reserve and renewing spermatogonial stem cells ... understanding of primate spermatogonia are also identified. ...

    Abstract The biology of spermatogonial stem cells is currently an area of intensive research and contemporary studies in primates are emerging. Quantitative regulation of sperm output by the primate testis seems to be exerted primarily on the transition from undifferentiated to differentiating spermatogonia. This review examines recent advances in our understanding of the mechanisms governing spermatogonial renewal and early differentiation in male primates, with a focus on the monkey. Emerging revisions to the classic view of dark and pale type A spermatogonia as reserve and renewing spermatogonial stem cells, respectively, are critically evaluated and essential features of endocrine control of undifferentiated spermatogonia throughout postnatal primate development are discussed. Obstacles in gaining a more complete understanding of primate spermatogonia are also identified.
    MeSH term(s) Animals ; Cell Differentiation ; Cell Proliferation ; Endocrine System/physiology ; Follicle Stimulating Hormone/blood ; Follicle Stimulating Hormone/physiology ; Humans ; Male ; Primates ; Rodentia ; Seminiferous Epithelium/cytology ; Seminiferous Epithelium/physiology ; Spermatogenesis/physiology ; Spermatogonia/cytology ; Spermatogonia/physiology
    Chemical Substances Follicle Stimulating Hormone (9002-68-0)
    Language English
    Publishing date 2010-03-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1042384-9
    ISSN 1879-3061 ; 1043-2760
    ISSN (online) 1879-3061
    ISSN 1043-2760
    DOI 10.1016/j.tem.2010.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2999: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Irisin is expressed by undifferentiated spermatogonia and modulates gene expression in organotypic primate testis cultures.

    Wahab, Fazal / Drummer, Charis / Mätz-Rensing, Kerstin / Fuchs, Eberhard / Behr, Rüdiger

    Molecular and cellular endocrinology

    2019  Volume 504, Page(s) 110670

    Abstract: ... of irisin in undifferentiated spermatogonia of primates and in the tree shrew, a bridging species between ... The molecular mechanisms regulating undifferentiated spermatogonial cell proliferation and ... of differentiation 117 (cKIT), and SALL4, compared to untreated controls, while irisin suppressed its own FNDC5 mRNA ...

    Abstract The molecular mechanisms regulating undifferentiated spermatogonial cell proliferation and differentiation are still not fully understood. Irisin is an exercise-induced hormone, which is a cleaved and secreted fragment of the fibronectin type III repeat containing 5 (FNDC5) transmembrane protein. Recent studies have demonstrated the role of irisin in cell proliferation and differentiation in various tissues. However, testicular irisin expression and its potential action have not been analyzed. Here, we demonstrate expression of irisin in undifferentiated spermatogonia of primates and in the tree shrew, a bridging species between primates and insectivores. Rhesus monkeys are seasonal breeders with annual phases of high and low testicular activity and germ cell proliferation. Interestingly, expression of both FNDC5 mRNA and irisin is altered between breeding (high spermatogenesis) and nonbreeding seasons (low spermatogenesis). Organotypic testis culture in the presence of irisin increased the expression levels of the Sertoli cell (GDNF) and spermatogonial transcripts Kruppel-like factor 4 (KLF4), Inhibitor of differentiation 4 (ID4), Cluster of differentiation 117 (cKIT), and SALL4, compared to untreated controls, while irisin suppressed its own FNDC5 mRNA. Our data suggest that irisin is a novel endocrine factor involved in the regulation of spermatogonial activities in the testes of primates.
    MeSH term(s) Animals ; Cell Culture Techniques/veterinary ; Cell Differentiation/genetics ; Cells, Cultured ; Fibronectins/genetics ; Fibronectins/metabolism ; Gene Expression ; Macaca mulatta ; Male ; Sertoli Cells/metabolism ; Spermatogenesis/genetics ; Spermatogonia/metabolism ; Spermatogonia/physiology ; Testis/metabolism
    Chemical Substances Fibronectins
    Language English
    Publishing date 2019-12-01
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 187438-x
    ISSN 1872-8057 ; 0303-7207
    ISSN (online) 1872-8057
    ISSN 0303-7207
    DOI 10.1016/j.mce.2019.110670
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1127: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Irisin is expressed by undifferentiated spermatogonia and modulates gene expression in organotypic primate testis cultures

    Wahab, Fazal / Drummer, Charis / Mätz-Rensing, Kerstin / Fuchs, Eberhard / Behr, Rüdiger

    Molecular and cellular endocrinology. 2020 Mar. 15, v. 504

    2020  

    Abstract: ... of irisin in undifferentiated spermatogonia of primates and in the tree shrew, a bridging species between ... The molecular mechanisms regulating undifferentiated spermatogonial cell proliferation and ... of differentiation 117 (cKIT), and SALL4, compared to untreated controls, while irisin suppressed its own FNDC5 mRNA ...

    Abstract The molecular mechanisms regulating undifferentiated spermatogonial cell proliferation and differentiation are still not fully understood. Irisin is an exercise-induced hormone, which is a cleaved and secreted fragment of the fibronectin type III repeat containing 5 (FNDC5) transmembrane protein. Recent studies have demonstrated the role of irisin in cell proliferation and differentiation in various tissues. However, testicular irisin expression and its potential action have not been analyzed. Here, we demonstrate expression of irisin in undifferentiated spermatogonia of primates and in the tree shrew, a bridging species between primates and insectivores. Rhesus monkeys are seasonal breeders with annual phases of high and low testicular activity and germ cell proliferation. Interestingly, expression of both FNDC5 mRNA and irisin is altered between breeding (high spermatogenesis) and nonbreeding seasons (low spermatogenesis). Organotypic testis culture in the presence of irisin increased the expression levels of the Sertoli cell (GDNF) and spermatogonial transcripts Kruppel-like factor 4 (KLF4), Inhibitor of differentiation 4 (ID4), Cluster of differentiation 117 (cKIT), and SALL4, compared to untreated controls, while irisin suppressed its own FNDC5 mRNA. Our data suggest that irisin is a novel endocrine factor involved in the regulation of spermatogonial activities in the testes of primates.
    Keywords Macaca mulatta ; Scandentia ; Sertoli cells ; breeding ; cell proliferation ; exercise ; fibronectins ; gene expression ; insectivores ; messenger RNA ; spermatogenesis ; spermatogonia ; tissues ; transmembrane proteins
    Language English
    Dates of publication 2020-0315
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 187438-x
    ISSN 1872-8057 ; 0303-7207
    ISSN (online) 1872-8057
    ISSN 0303-7207
    DOI 10.1016/j.mce.2019.110670
    Database NAL-Catalogue (AGRICOLA)

    Full text online

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1127: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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