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  1. Article ; Online: Extensive and diverse patterns of cell death sculpt neural networks in insects.

    Pop, Sinziana / Chen, Chin-Lin / Sproston, Connor J / Kondo, Shu / Ramdya, Pavan / Williams, Darren W

    eLife

    2020  Volume 9

    Abstract: Changes to the structure and function of neural networks are thought to underlie ... programmed cell death (PCD) appears to play a key role. We show that cell death occurs continuously throughout insect ... neurogenesis and happens soon after neurons are born. Mimicking an evolutionary role for increasing ...

    Abstract Changes to the structure and function of neural networks are thought to underlie the evolutionary adaptation of animal behaviours. Among the many developmental phenomena that generate change programmed cell death (PCD) appears to play a key role. We show that cell death occurs continuously throughout insect neurogenesis and happens soon after neurons are born. Mimicking an evolutionary role for increasing cell numbers, we artificially block in the medial neuroblast lineage in
    MeSH term(s) Animals ; Apoptosis/physiology ; Biological Evolution ; Drosophila Proteins/metabolism ; Drosophila melanogaster ; Flight, Animal/physiology ; Nerve Net/cytology ; Nerve Net/physiology ; Neurogenesis/physiology ; Neurons/cytology ; Neurons/physiology
    Chemical Substances Drosophila Proteins
    Keywords covid19
    Language English
    Publishing date 2020-09-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.59566
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Extensive and diverse patterns of cell death sculpt neural networks in insects

    Sinziana Pop / Chin-Lin Chen / Connor J Sproston / Shu Kondo / Pavan Ramdya / Darren W Williams

    eLife, Vol

    2020  Volume 9

    Abstract: Changes to the structure and function of neural networks are thought to underlie ... programmed cell death (PCD) appears to play a key role. We show that cell death occurs continuously throughout insect ... identities. Activation of these ‘undead’ neurons and recordings of neural activity in behaving animals ...

    Abstract Changes to the structure and function of neural networks are thought to underlie the evolutionary adaptation of animal behaviours. Among the many developmental phenomena that generate change programmed cell death (PCD) appears to play a key role. We show that cell death occurs continuously throughout insect neurogenesis and happens soon after neurons are born. Mimicking an evolutionary role for increasing cell numbers, we artificially block PCD in the medial neuroblast lineage in Drosophila melanogaster, which results in the production of ‘undead’ neurons with complex arborisations and distinct neurotransmitter identities. Activation of these ‘undead’ neurons and recordings of neural activity in behaving animals demonstrate that they are functional. Focusing on two dipterans which have lost flight during evolution we reveal that reductions in populations of flight interneurons are likely caused by increased cell death during development. Our findings suggest that the evolutionary modulation of death-based patterning could generate novel network configurations.
    Keywords Braula coeca ; Crataerina pallida ; Thermobia domestica ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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