Article ; Online: Preventive Effects of Oxidized Dextran on Functional Activity of Pulmonary Macrophages in Mice Infected with Influenza A Virus.
Bulletin of experimental biology and medicine
2018 Volume 165, Issue 1, Page(s) 57–60
Abstract: ... influenza A/H5N1 virus after preventive injections of oxidized dextran. Light microscopy ... We analyzed cytokine profile of pulmonary macrophages in mice infected with highly pathogenic ... immunohistochemistry, and morphometric examinations showed that preventive injections of oxidized dextran led to more ...
| Abstract | We analyzed cytokine profile of pulmonary macrophages in mice infected with highly pathogenic influenza A/H5N1 virus after preventive injections of oxidized dextran. Light microscopy, immunohistochemistry, and morphometric examinations showed that preventive injections of oxidized dextran led to more effective virus elimination, modulation of the proinflammatory cytokine response, and host antiviral response and reduce animal mortality. Our findings allow recommending oxidized dextran for further studies in order to create a vaccine with antiviral and adjuvant potencies. |
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| MeSH term(s) | Animals ; Antiviral Agents/chemistry ; Antiviral Agents/therapeutic use ; Dextrans/chemistry ; Dextrans/therapeutic use ; Influenza A Virus, H5N1 Subtype/drug effects ; Influenza A Virus, H5N1 Subtype/pathogenicity ; Influenza A virus/drug effects ; Influenza A virus/pathogenicity ; Macrophages, Alveolar/virology ; Male ; Mice ; Nitric Oxide Synthase/metabolism ; Orthomyxoviridae Infections/drug therapy ; Orthomyxoviridae Infections/prevention & control ; Oxidation-Reduction | |||||
| Chemical Substances | Antiviral Agents ; Dextrans ; Nitric Oxide Synthase (EC 1.14.13.39) | |||||
| Language | English | |||||
| Publishing date | 2018-05-24 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 390407-6 | |||||
| ISSN | 1573-8221 ; 0007-4888 ; 0365-9615 | |||||
| ISSN (online) | 1573-8221 | |||||
| ISSN | 0007-4888 ; 0365-9615 | |||||
| DOI | 10.1007/s10517-018-4098-6 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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