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  1. Article ; Online: Recent developments in intestinal magnesium absorption.

    Quamme, Gary A

    Current opinion in gastroenterology

    2008  Volume 24, Issue 2, Page(s) 230–235

    Abstract: ... but the role of these proteins is unclear.: Summary: The recent developments in intestinal magnesium ... clarified our understanding of intestinal magnesium absorption. The predominant Mg transporters include ... this phosphotransferase kinase. TRPM6 channel function and intestinal magnesium absorption is altered by a variety ...

    Abstract Purpose of review: Recent identification and characterization of novel Mg transporters have clarified our understanding of intestinal magnesium absorption. The predominant Mg transporters include TRPM6 and TRPM7, members of the transient receptor potential melastatin family of cation channels. Mutations of TRPM6 result in a primary disorder termed hypomagnesemia with secondary hypocalcemia.
    Recent findings: Both TRPM6 and TRPM7 channels possess an atypical alpha-kinase domain. Recent studies have shown that TRPM7 channel activity is regulated by intracellular Mg and magnesium-nucleotides and modulated via this phosphotransferase kinase. TRPM6 channel function and intestinal magnesium absorption is altered by a variety of hormones and factors. Although it is apparent that TRPM6 and TRPM7 form heteromeric ion channels, controversy surrounds the nature of this interaction. Some studies show that TRPM6 may function on its own whereas other research concludes that TRPM7 is required for effective trafficking of TRPM6 to the plasma membrane. Finally, a number of other Mg transporters have been identified in intestinal epithelial cells but the role of these proteins is unclear.
    Summary: The recent developments in intestinal magnesium absorption and cellular magnesium homeostasis provide a basis for understanding magnesium deficiency disorders and provide a platform for future investigations.
    MeSH term(s) Humans ; Intestines/physiology ; Magnesium/metabolism ; Magnesium/physiology ; Protein-Serine-Threonine Kinases ; TRPM Cation Channels/physiology
    Chemical Substances TRPM Cation Channels ; TRPM6 protein, human ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; TRPM7 protein, human (EC 2.7.11.1) ; Magnesium (I38ZP9992A)
    Language English
    Publishing date 2008-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632571-3
    ISSN 1531-7056 ; 0267-1379
    ISSN (online) 1531-7056
    ISSN 0267-1379
    DOI 10.1097/MOG.0b013e3282f37b59
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2072: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Magnesium: The recent research and developments.

    Al Alawi, Abdullah M / Al Badi, Amira / Al Huraizi, Aisha / Falhammar, Henrik

    Advances in food and nutrition research

    2021  Volume 96, Page(s) 193–218

    Abstract: ... closely regulate magnesium absorption and elimination to maintain adequate storage of magnesium ... Magnesium is the fourth most abundant mineral in the human body, which facilitates more than 300 ... enzymatic reactions. Magnesium is essential for nucleic material and protein synthesis, neuromuscular conduction ...

    Abstract Magnesium is the fourth most abundant mineral in the human body, which facilitates more than 300 enzymatic reactions. Magnesium is essential for nucleic material and protein synthesis, neuromuscular conduction, cardiac contractility, energy metabolism, and immune system function. Gastrointestinal system and kidneys closely regulate magnesium absorption and elimination to maintain adequate storage of magnesium. Magnesium deficiency has been linked to many diseases and poor health outcomes. Magnesium has also been proven to be an effective therapeutic agent in many diseases, such as bronchial asthma, cardiac arrhythmia, and pre-eclampsia.
    MeSH term(s) Eating ; Energy Metabolism ; Humans ; Magnesium ; Magnesium Deficiency ; Research
    Chemical Substances Magnesium (I38ZP9992A)
    Language English
    Publishing date 2021-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1011108-6
    ISSN 1043-4526
    ISSN 1043-4526
    DOI 10.1016/bs.afnr.2021.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.250: Show issues Location:
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  3. Article: Recent data on the evaluation of magnesium bioavailability in humans.

    Benech, H / Grognet, J M

    Magnesium research

    1995  Volume 8, Issue 3, Page(s) 277–284

    Abstract: ... absorption and the latter is subject to the fragile balance of magnesium urinary excretion. Isotope studies ... such as magnesium, cannot be performed by the conventional measurement of plasma levels after intravenous and/or ... oral administration. In the case of magnesium, this is emphasized by the fact that plasma levels are quickly regulated ...

    Abstract Assessment of the bioavailability of exogenous ions present in a large amounts in the body, such as magnesium, cannot be performed by the conventional measurement of plasma levels after intravenous and/or oral administration. In the case of magnesium, this is emphasized by the fact that plasma levels are quickly regulated, mainly by the kidney and in storage compartments such as bone, after exogenous administration. Magnesium bioavailability and absorption are studied by indirect methods or by using radioactive or stable isotopes as tracers. Indirect methods are the metabolic balance method and comparison of urinary excretion between a treatment and a placebo period, often after magnesium load. However, the former only measures magnesium absorption and the latter is subject to the fragile balance of magnesium urinary excretion. Isotope studies, in particular with stable isotope probes, have benefited from the developments in mass spectrometry, such as inductively coupled plasma mass spectrometry (ICP-MS). It is possible to follow exogenous magnesium in plasma after oral and intravenous administrations using 25Mg and 26Mg as tracers, and to calculate the absolute bioavailability of magnesium.
    MeSH term(s) Biological Availability ; Humans ; Intestinal Absorption ; Magnesium/administration & dosage ; Magnesium/blood ; Magnesium/pharmacokinetics
    Chemical Substances Magnesium (I38ZP9992A)
    Language English
    Publishing date 1995-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1036384-1
    ISSN 0953-1424
    ISSN 0953-1424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2658: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Recent progress on research and applications of non-digestible galacto-oligosaccharides

    Sako, T / Matsumoto, K / Tanaka, R

    International dairy journal / 1999. v. 9 (1)

    1999  

    Abstract: ... epithelium, and calcium and magnesium absorption. These physiological effects in conjunction ... of bifidogenic activity of GOS and the development of an industrial production process by transgalactosidase ... on the intestinal flora and functions. GOS are selectively utilized by bifidobacteria in vitro, and show a bifidogenic ...

    Abstract Galacto-oligosaccharides (GOS) are non-digestible carbohydrates, which are resistant to gastrointestinal digestive enzymes, but are fermented by specific colonic bacteria. After the discovery of bifidogenic activity of GOS and the development of an industrial production process by transgalactosidase activity of beta-galactosidases. GOS have been extensively studied for their physiological roles on the intestinal flora and functions. GOS are selectively utilized by bifidobacteria in vitro, and show a bifidogenic effect at a daily intake of more than 2.5 g in human studies, whereas at least 5 g are needed to have effects on stool frequency. It is suggested that the products of fermentation of GOS in the colon, mainly short chain fatty acids, have a role in the improvement of the colonic environment, energy supply to the colonic epithelium, and calcium and magnesium absorption. These physiological effects in conjunction with the physicochemical characteristics of GOS enable GOS to be promising prebiotic food ingredients applicable to a variety of designed foods.
    Keywords oligosaccharides ; intestinal microorganisms ; colon ; Bifidobacterium ; short chain fatty acids ; bile acids ; humans ; enzyme activity ; rats ; food safety ; prebiotics ; feces composition
    Language English
    Size p. 69-80.
    Document type Article
    Note In the special issue: Recombinant dairy starters, probiotics, and prebiotics: scientific, technological, and regulatory challenges / edited by J. Delcour, L. De Vuyst, and C. Shortt. Proceedings of the Ninth European Congress on Biotechnology held July 11-15, 1999, Brussels.
    ZDB-ID 1076400-8
    ISSN 0958-6946
    ISSN 0958-6946
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 5292: Show issues

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