Article: Molecular regulation of HDL metabolism and function: implications for novel therapies.
The Journal of clinical investigation
2006 Volume 116, Issue 12, Page(s) 3090–3100
Abstract: ... regulation of HDL metabolism, macrophage cholesterol efflux, and HDL function will lead to a variety of novel ... of HDL apolipoprotein and HDL cholesterol metabolism. Advances in our understanding of the molecular ... HDL metabolism represents a major target for the development of therapies intended to reduce ...
| Abstract | HDL metabolism represents a major target for the development of therapies intended to reduce the risk of atherosclerotic cardiovascular disease. HDL metabolism is complex and involves dissociation of HDL apolipoprotein and HDL cholesterol metabolism. Advances in our understanding of the molecular regulation of HDL metabolism, macrophage cholesterol efflux, and HDL function will lead to a variety of novel therapeutics. |
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| MeSH term(s) | Animals ; Apolipoprotein A-I/metabolism ; Arteriosclerosis/drug therapy ; Arteriosclerosis/metabolism ; Arteriosclerosis/physiopathology ; Cholesterol/metabolism ; Cholesterol, HDL/metabolism ; Humans ; Lipoproteins, HDL/metabolism ; Lipoproteins, HDL/physiology ; Models, Biological | |||||
| Chemical Substances | Apolipoprotein A-I ; Cholesterol, HDL ; Lipoproteins, HDL ; Cholesterol (97C5T2UQ7J) | |||||
| Language | English | |||||
| Publishing date | 2006-12 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review | |||||
| ZDB-ID | 3067-3 | |||||
| ISSN | 1558-8238 ; 0021-9738 | |||||
| ISSN (online) | 1558-8238 | |||||
| ISSN | 0021-9738 | |||||
| DOI | 10.1172/JCI30163 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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