Artikel: MHC class I assembly: out and about.
2008 Band 29, Heft 9, Seite(n) 436–443
Abstract: ... of function of the various assembly factors and pathways by which exogenous antigens access MHC class ... The assembly of major histocompatibility complex (MHC) class I molecules with peptides is ... orchestrated by several assembly factors including the transporter associated with antigen processing (TAP) and ...
| Abstract | The assembly of major histocompatibility complex (MHC) class I molecules with peptides is orchestrated by several assembly factors including the transporter associated with antigen processing (TAP) and tapasin, the endoplasmic reticulum (ER) oxido-reductases ERp57 and protein disulfide isomerase (PDI), the lectin chaperones calnexin and calreticulin, and the ER aminopeptidase (ERAAP). Typically, MHC class I molecules present endogenous antigens to cytotoxic T lymphocytes (CTLs). However, the initiation of CD8(+) T-cell responses against many pathogens and tumors also requires the presentation of exogenous antigens by MHC class I molecules. We discuss recent developments relating to interactions and mechanisms of function of the various assembly factors and pathways by which exogenous antigens access MHC class I molecules. |
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| Mesh-Begriff(e) | ATP-Binding Cassette Transporters/immunology ; ATP-Binding Cassette Transporters/metabolism ; Animals ; Antigen Presentation/immunology ; Cross-Priming/immunology ; Histocompatibility Antigens Class I/immunology ; Histocompatibility Antigens Class I/metabolism ; Humans ; Leucyl Aminopeptidase/immunology ; Leucyl Aminopeptidase/metabolism ; Membrane Transport Proteins/immunology ; Membrane Transport Proteins/metabolism ; Models, Immunological ; Peptides/immunology ; Peptides/metabolism | ||||||||||
| Chemische Substanzen | ATP-Binding Cassette Transporters ; Histocompatibility Antigens Class I ; Membrane Transport Proteins ; Peptides ; tapasin ; transporter associated with antigen processing (TAP) ; Leucyl Aminopeptidase (EC 3.4.11.1) ; puromycin-insensitive leucyl-specific aminopeptidase (EC 3.4.11.1) | ||||||||||
| Sprache | Englisch | ||||||||||
| Erscheinungsdatum | 2008-07-04 | ||||||||||
| Erscheinungsland | England | ||||||||||
| Dokumenttyp | Journal Article ; Research Support, N.I.H., Extramural ; Review | ||||||||||
| ZDB-ID | 2036831-8 | ||||||||||
| ISSN | 1471-4981 ; 1471-4906 | ||||||||||
| ISSN (online) | 1471-4981 | ||||||||||
| ISSN | 1471-4906 | ||||||||||
| DOI | 10.1016/j.it.2008.06.004 | ||||||||||
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| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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