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  1. Article ; Online: Hematologic disorders associated with COVID-19: a review.

    Rahi, Mandeep Singh / Jindal, Vishal / Reyes, Sandra-Patrucco / Gunasekaran, Kulothungan / Gupta, Ruby / Jaiyesimi, Ishmael

    Annals of hematology

    2021  Volume 100, Issue 2, Page(s) 309–320

    Abstract: ... in hematologic biomarkers such as lactate dehydrogenase, D-dimer, ferritin, and C-reactive protein are associated ... on the coagulation system is associated with significant morbidity and mortality. The disease can cause both arterial ... with worse outcomes. Understanding the pathophysiology and recognizing factors associated with poor prognosis ...

    Abstract Coronavirus disease 2019 is caused by severe acute respiratory syndrome coronavirus 2. Primarily an infection of the lower respiratory tract, it is now well known to cause multisystem abnormalities. Hematologic manifestations constitute a significant area of concern. Severe acute respiratory syndrome coronavirus 2 infects monocytes and endothelial cells leading to a complex downstream cascade, cytokine storm, and eventual intravascular thrombosis. Coronavirus disease 2019 causes lymphopenia, neutrophilia, and thrombocytopenia. Prophylactic anticoagulation is vital in patients with coronavirus disease 2019, as its effect on the coagulation system is associated with significant morbidity and mortality. The disease can cause both arterial and venous thromboses, especially pulmonary embolism and pulmonary microthrombi. A high index of suspicion is indispensable in recognizing these complications, and timely institution of therapeutic anticoagulation is vital in treating them. Virus-induced disseminated intravascular coagulation is uncommon but shares some similarities to sepsis-induced disseminated intravascular coagulation. Marked elevations in hematologic biomarkers such as lactate dehydrogenase, D-dimer, ferritin, and C-reactive protein are associated with worse outcomes. Understanding the pathophysiology and recognizing factors associated with poor prognosis are crucial in improving patient outcomes with coronavirus disease 2019.
    MeSH term(s) Anticoagulants/therapeutic use ; Biomarkers/blood ; COVID-19/complications ; COVID-19/prevention & control ; COVID-19/virology ; Ferritins/blood ; Fibrin Fibrinogen Degradation Products/analysis ; Hematologic Diseases/blood ; Hematologic Diseases/complications ; Hematologic Diseases/drug therapy ; Humans ; Lymphopenia/blood ; Lymphopenia/complications ; Lymphopenia/drug therapy ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/physiology ; Thrombocytopenia/blood ; Thrombocytopenia/complications ; Thrombocytopenia/drug therapy
    Chemical Substances Anticoagulants ; Biomarkers ; Fibrin Fibrinogen Degradation Products ; fibrin fragment D ; Ferritins (9007-73-2)
    Language English
    Publishing date 2021-01-07
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-020-04366-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Real-World Third COVID-19 Vaccine Dosing and Antibody Response in Patients With Hematologic Malignancies.

    Thompson, Michael A / Hallmeyer, Sigrun / Fitzpatrick, Veronica E / Liao, Yunqi / Mullane, Michael P / Medlin, Stephen C / Copeland, Kenneth / Weese, James L

    Journal of patient-centered research and reviews

    2022  Volume 9, Issue 3, Page(s) 149–157

    Abstract: ... Response to 3V was significantly associated with the 3V vaccine type (P=0.0006), previous COVID-19 ... of either Pfizer's or Moderna's COVID-19 mRNA vaccine (3V) among patients with hematologic malignancies, as well ... significant increase in the proportion of seropositivity after receiving a third COVID-19 vaccine (P<0.00001 ...

    Abstract Purpose: This study sought to describe the changes in immune response to a third dose of either Pfizer's or Moderna's COVID-19 mRNA vaccine (3V) among patients with hematologic malignancies, as well as associated characteristics.
    Methods: This retrospective cohort study analyzed pre-3V and post-3V data on 493 patients diagnosed with hematologic malignancies across a large Midwestern health system between August 28, 2021, and November 1, 2021. For antibody testing, S1 spike antigen of the SARS-CoV-2 virus titer was used to determine serostatus.
    Results: Among 493 participants, 274 (55.6%) were seropositive both pre- and post-3V (+/+) while 115 (23.3%) seroconverted to positive from prior negative following the third dose (-/+). The remaining 104 (21.1%) were seronegative both before and after 3V (-/-). No participant was seropositive pre-3V and seronegative post-3V (+/-). Results showed a statistically significant increase in the proportion of seropositivity after receiving a third COVID-19 vaccine (P<0.00001). Response to 3V was significantly associated with the 3V vaccine type (P=0.0006), previous COVID-19 infection (P=0.0453), and malignancy diagnosis (P<0.0001). Likelihood of seroconversion (-/+) after 3V was higher in the group of patients with multiple myeloma or related disorders compared to patients with lymphoid leukemias (odds ratio: 8.22, 95% CI: 2.12-31.79; P=0.0008).
    Conclusions: A third COVID-19 vaccination is effective in producing measurable seroconversion in many patients with hematologic malignancies. Oncologists should actively encourage all their patients, especially those with multiple myeloma, to receive a 3V, given the high likelihood of seroconversion.
    Language English
    Publishing date 2022-07-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3022292-8
    ISSN 2330-0698 ; 2330-068X
    ISSN (online) 2330-0698
    ISSN 2330-068X
    DOI 10.17294/2330-0698.1952
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  3. Article ; Online: Hematological aspects of the COVID-19 syndrome.

    Malkan, U Y / Haznedaroglu, I C

    European review for medical and pharmacological sciences

    2022  Volume 26, Issue 12, Page(s) 4463–4476

    Abstract: ... of this paper is to review the hematologic aspects of COVID-19 syndrome and the potential management options ... of COVID-19 associated thrombosis are comprehensively described in this paper.: Conclusions: The final ... the clinical prognosis of blood disorders. SARS-CoV-2 and COVID-19, as a viral disease, can have serious impact ...

    Abstract Objective: Viral infections could complicate hematopoiesis and, in some cases, they may worsen the clinical prognosis of blood disorders. SARS-CoV-2 and COVID-19, as a viral disease, can have serious impact on the disease course of hematological neoplastic diseases and can cause hematological complications. The aim of this paper is to review the hematologic aspects of COVID-19 syndrome and the potential management options for SARS-CoV-2 including the convalescent plasma, hemostatic agents and proper anticoagulant treatment.
    Materials and methods: Up to February 2022, literature searches were performed using the internet search engines MEDLINE and EMBASE: (i) COVID-19; (ii) Hematology. PRISMA flow diagram described the COVID-19 and hematology search.
    Results: According to our COVID-19 and hematology research on research databases, we included 82 studies in the current paper. The issues of the impact of the COVID-19 pandemic on hematological diseases, the role of t-lymphocytes in donor lymphocyte infusion and viruses, hemato-immunologic research in COVID-19, local bone marrow renin-angiotensin system and viral infections, clinical management of COVID-19 infection via hemostatic agents, immune plasma treatment of COVID-19, anticoagulant treatment of COVID-19 associated thrombosis are comprehensively described in this paper.
    Conclusions: The final episode of this pandemic will include the "chimerism-mediated immunotherapy" that will eventually lead to end of the COVID-19 process. The recent Omicron variant seems to have unique evasion effects on the interferon gene expression which will boost the chimerism-mediated immunotherapy without high mortality rates.
    MeSH term(s) Anticoagulants/therapeutic use ; COVID-19/therapy ; Humans ; Immunization, Passive ; Pandemics ; SARS-CoV-2 ; Syndrome
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2022-07-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202206_29086
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1887: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Hematological changes in patients with COVID‑19 (Review).

    Ye, Jieyu / Jiao, Yingying / Zhang, Yujiao / Li, Zongpeng / Zeng, Xiaoyuan / Deng, Huixia / Yang, Mo

    Molecular medicine reports

    2020  Volume 22, Issue 6, Page(s) 4485–4491

    Abstract: ... thrombocytopenia and coagulation disorders. However, to the best of our knowledge, the pathogenesis of COVID‑19 ... associated with respiratory system dysfunction and hematological changes, including lymphopenia ... severe acute respiratory syndrome‑CoV‑2 and the disease CoV disease‑19 (COVID‑19). Patients with COVID‑19 present with symptoms ...

    Abstract In December 2019, an emergence of pneumonia was detected in patients infected with a novel coronavirus (CoV) in Wuhan (Hubei, China). The International Committee on Taxonomy of Viruses named the virus severe acute respiratory syndrome‑CoV‑2 and the disease CoV disease‑19 (COVID‑19). Patients with COVID‑19 present with symptoms associated with respiratory system dysfunction and hematological changes, including lymphopenia, thrombocytopenia and coagulation disorders. However, to the best of our knowledge, the pathogenesis of COVID‑19 remains unclear. Therefore, understanding the mechanisms underlying the hematological changes that manifest during COVID‑19 may aid in the development of treatments and may improve patient prognosis.
    MeSH term(s) Antibodies, Viral/immunology ; Antigen-Antibody Complex/immunology ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Betacoronavirus/immunology ; Cellular Microenvironment ; Coronavirus Infections/blood ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Coronavirus Infections/therapy ; Cytokine Release Syndrome/blood ; Cytokine Release Syndrome/etiology ; Cytokine Release Syndrome/prevention & control ; Cytokines/blood ; Diagnostic Tests, Routine ; Endothelium, Vascular/pathology ; Hematologic Tests ; Hematopoiesis/drug effects ; Hematopoietic Stem Cells/pathology ; Humans ; Hypoalbuminemia/etiology ; Liver/physiopathology ; Lung/physiopathology ; Lymphopenia/etiology ; Lymphopenia/physiopathology ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/therapy ; Reperfusion Injury/etiology ; Thrombocytopenia/etiology ; Thrombocytopenia/physiopathology ; Thrombophilia/etiology
    Chemical Substances Antibodies, Viral ; Antigen-Antibody Complex ; Antiviral Agents ; Cytokines
    Keywords covid19
    Language English
    Publishing date 2020-10-11
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 2469505-1
    ISSN 1791-3004 ; 1791-2997
    ISSN (online) 1791-3004
    ISSN 1791-2997
    DOI 10.3892/mmr.2020.11581
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  5. Article: Hematological changes in patients with COVID­19 (Review)

    Ye, Jieyu / Jiao, Yingying / Zhang, Yujiao / Li, Zongpeng / Zeng, Xiaoyuan / Deng, Huixia / Yang, Mo

    Mol Med Rep

    Abstract: ... thrombocytopenia and coagulation disorders. However, to the best of our knowledge, the pathogenesis of COVID­19 ... associated with respiratory system dysfunction and hematological changes, including lymphopenia ... severe acute respiratory syndrome­CoV­2 and the disease CoV disease­19 (COVID­19). Patients with COVID­19 present with symptoms ...

    Abstract In December 2019, an emergence of pneumonia was detected in patients infected with a novel coronavirus (CoV) in Wuhan (Hubei, China). The International Committee on Taxonomy of Viruses named the virus severe acute respiratory syndrome­CoV­2 and the disease CoV disease­19 (COVID­19). Patients with COVID­19 present with symptoms associated with respiratory system dysfunction and hematological changes, including lymphopenia, thrombocytopenia and coagulation disorders. However, to the best of our knowledge, the pathogenesis of COVID­19 remains unclear. Therefore, understanding the mechanisms underlying the hematological changes that manifest during COVID­19 may aid in the development of treatments and may improve patient prognosis.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #918906
    Database COVID19

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  6. Article ; Online: COVID-19 in benign hematology: emerging challenges and special considerations for healthcare professionals.

    Noun, Peter / Ibrahim, Ahmad / Hodroj, Mohammad Hassan / Bou-Fakhredin, Rayan / Taher, Ali T

    Expert review of hematology

    2020  Volume 13, Issue 10, Page(s) 1081–1092

    Abstract: ... these patients if they are infected with SARS-CoV-2. To review the literature on benign hematological disorders ... at increased risk of developing severe complications from COVID-19. These patients, therefore, require specific ... follow-up consultations and hospital visits. The current COVID-19 pandemic is therefore presenting ...

    Abstract Introduction: Many patients with inherited or acquired benign hematological disorders are at increased risk of developing severe complications from COVID-19. These patients, therefore, require specific advice regarding isolation and changes to their usual treatment schedules. Their disease can also be associated with significant burden, and they necessitate life-long and regular access to therapy, and regular follow-up consultations and hospital visits. The current COVID-19 pandemic is therefore presenting many challenges for these patients, their families, and health-care professionals.
    Areas covered: This review provides an overview of the reported COVID-19 cases in the literature in patients with certain benign hematological disorders including thalassemia, sickle cell disease, hemophilia, immune thrombocytopenia, venous thromboembolism, and aplastic anemia. The review also outlines some recommendations on how to manage these patients if they are infected with SARS-CoV-2. To review the literature on benign hematological disorders and COVID-19, a bibliographic search was performed using PubMed for articles published between January 2020 and June 2020.
    Expert opinion: International efforts must be made to continue reporting and better understanding the effects of SARS-CoV-2 infection in these patients and accordingly develop a set of recommendations to optimize the treatment of future infected patients.
    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Disease Management ; Health Personnel ; Hematologic Diseases/complications ; Hematologic Diseases/therapy ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2516804-6
    ISSN 1747-4094 ; 1747-4086
    ISSN (online) 1747-4094
    ISSN 1747-4086
    DOI 10.1080/17474086.2020.1819785
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    Zs.A 6943: Show issues Location:
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  7. Article: COVID-19 in benign hematology: emerging challenges and special considerations for healthcare professionals

    Noun, Peter / Ibrahim, Ahmad / Hodroj, Mohammad Hassan / Bou-Fakhredin, Rayan / Taher, Ali T

    Expert Rev Hematol

    Abstract: ... these patients if they are infected with SARS-CoV-2. To review the literature on benign hematological disorders ... at increased risk of developing severe complications from COVID-19. These patients, therefore, require specific ... follow-up consultations and hospital visits. The current COVID-19 pandemic is therefore presenting ...

    Abstract INTRODUCTION: Many patients with inherited or acquired benign hematological disorders are at increased risk of developing severe complications from COVID-19. These patients, therefore, require specific advice regarding isolation and changes to their usual treatment schedules. Their disease can also be associated with significant burden, and they necessitate life-long and regular access to therapy, and regular follow-up consultations and hospital visits. The current COVID-19 pandemic is therefore presenting many challenges for these patients, their families, and health-care professionals. AREAS COVERED: This review provides an overview of the reported COVID-19 cases in the literature in patients with certain benign hematological disorders including thalassemia, sickle cell disease, hemophilia, immune thrombocytopenia, venous thromboembolism, and aplastic anemia. The review also outlines some recommendations on how to manage these patients if they are infected with SARS-CoV-2. To review the literature on benign hematological disorders and COVID-19, a bibliographic search was performed using PubMed for articles published between January 2020 and June 2020. EXPERT OPINION: International efforts must be made to continue reporting and better understanding the effects of SARS-CoV-2 infection in these patients and accordingly develop a set of recommendations to optimize the treatment of future infected patients.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #759836
    Database COVID19

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