Article ; Online: Microsampling: A role to play in Covid-19 diagnosis, surveillance, treatment and clinical trials.
2021 Volume 13, Issue 7, Page(s) 1238–1248
Abstract: ... in diagnosis, therapeutic drug monitoring, development of treatment or vaccines and clinical trials for Covid ... and resources was another barrier. In this scenario, microsampling played an important role due ... techniques are contributing effectively to the Covid-19 pandemic by reducing the demand for clinical staff ...
| Abstract | The outbreak of the new coronavirus disease changed the world upside down. Every day, millions of people were subjected to diagnostic testing for Covid-19, all over the world. Molecular tests helped in the diagnosis of current infection by detecting the presence of viral genome whereas serological tests helped in detecting the presence of antibody in blood as well as contributed to vaccine development. This testing helped in understanding the immunogenicity, community prevalence, geographical spread and conditions post-infection. However, with the contagious nature of the virus, biological specimen sampling involved the risk of transmission and spread of infection. Clinic or pathology visit was the most concerning part. Trained personnel and resources was another barrier. In this scenario, microsampling played an important role due to its most important advantage of remote, contactless, small volume and self-sampling. Minimum requirements for sample storage and ease of shipment added value in this situation. The highly sensitive instruments and validated assay formats assured the accuracy of results and stability of samples. Microsampling techniques are contributing effectively to the Covid-19 pandemic by reducing the demand for clinical staff in population-level testing. The validated and established applications supported the use of microsampling in diagnosis, therapeutic drug monitoring, development of treatment or vaccines and clinical trials for Covid-19. |
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| MeSH term(s) | Antiviral Agents/therapeutic use ; COVID-19/diagnosis ; COVID-19/drug therapy ; COVID-19 Testing ; COVID-19 Vaccines/therapeutic use ; Clinical Trials as Topic ; Drug Monitoring ; Humans ; Population Surveillance ; Predictive Value of Tests ; Specimen Handling | |||||
| Chemical Substances | Antiviral Agents ; COVID-19 Vaccines | |||||
| Language | English | |||||
| Publishing date | 2021-06-15 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 2462336-2 | |||||
| ISSN | 1942-7611 ; 1942-7603 | |||||
| ISSN (online) | 1942-7611 | |||||
| ISSN | 1942-7603 | |||||
| DOI | 10.1002/dta.3107 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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