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  1. Article ; Online: Neonatal meningococcal disease: an update.

    Filippakis, Dimitrios / Gkentzi, Despoina / Dimitriou, Gabriel / Karatza, Ageliki

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

    2020  Volume 35, Issue 21, Page(s) 4190–4195

    Abstract: Purpose of the review: ...

    Abstract Purpose of the review:
    MeSH term(s) Child ; Clinical Deterioration ; Conjunctivitis ; Female ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases ; Meningococcal Infections ; Neisseria meningitidis ; Sepsis
    Language English
    Publishing date 2020-11-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2077261-0
    ISSN 1476-4954 ; 1057-0802 ; 1476-7058
    ISSN (online) 1476-4954
    ISSN 1057-0802 ; 1476-7058
    DOI 10.1080/14767058.2020.1849092
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  2. Article: Meningococcal Disease.

    Burnett, Mark W

    Journal of special operations medicine : a peer reviewed journal for SOF medical professionals

    2017  Volume 17, Issue 1, Page(s) 90–92

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Blood Culture ; Humans ; Meningitis, Meningococcal/complications ; Meningitis, Meningococcal/diagnosis ; Meningitis, Meningococcal/drug therapy ; Meningitis, Meningococcal/prevention & control ; Meningococcal Infections/diagnosis ; Meningococcal Infections/drug therapy ; Meningococcal Infections/prevention & control ; Meningococcal Vaccines/therapeutic use ; Multiplex Polymerase Chain Reaction ; Purpura/etiology ; Sepsis/complications ; Sepsis/diagnosis ; Sepsis/drug therapy ; Sepsis/prevention & control ; Spinal Puncture
    Chemical Substances Anti-Bacterial Agents ; Meningococcal Vaccines
    Language English
    Publishing date 2017-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3006517-3
    ISSN 1553-9768
    ISSN 1553-9768
    DOI 10.55460/URE1-Z992
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  3. Article ; Online: Green neutrophilic inclusions in meningococcal sepsis.

    Shackleton, Louisa / Melotti, Dario / Leddy, Catherine / Glavey, Siobhan / Thornton, Patrick / Quinn, John

    International journal of laboratory hematology

    2020  Volume 43, Issue 2, Page(s) e95–e96

    MeSH term(s) Humans ; Inclusion Bodies ; Sepsis
    Language English
    Publishing date 2020-12-08
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2268590-X
    ISSN 1751-553X ; 1751-5521 ; 0141-9854
    ISSN (online) 1751-553X
    ISSN 1751-5521 ; 0141-9854
    DOI 10.1111/ijlh.13422
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  4. Article ; Online: Meningococcal disease in the Middle East: A report from the Global Meningococcal Initiative.

    Al-Abri, Seif S / Abuhasan, Musallam Yunus / Albayat, Soha Shawqi A / Bai, Xilian / Bastaki, Hamad / Borrow, Ray / Caugant, Dominique A / Dbaibo, Ghassan / Deghmane, Ala-Eddine / Dinleyici, Ener Cagri / Ghuneim, Nedal / Sheek-Hussein, Mohamud / Lucidarme, Jay / Leng, Sean / Koliou, Maria G / Sáfadi, Marco A P / Salman, Jameela Al / Al-Sanouri, Tarek / Smith, Vinny /
    Taha, Muhamed-Kheir / Vázquez, Julio / Wright, Claire / Yezli, Saber

    The Journal of infection

    2023  Volume 88, Issue 2, Page(s) 71–76

    Abstract: This review details recent findings from the Global Meningococcal Initiative's (GMI) recent meeting ... on the surveillance and control strategies for invasive meningococcal disease in the Middle East. The nature ... as an IMD case definition in lieu of meningitis and septicaemia. This may overlook a significant burden ...

    Abstract This review details recent findings from the Global Meningococcal Initiative's (GMI) recent meeting on the surveillance and control strategies for invasive meningococcal disease in the Middle East. The nature of case reporting and notification varies across the region, with many countries using bacterial meningitis as an IMD case definition in lieu of meningitis and septicaemia. This may overlook a significant burden associated with IMD leading to underreporting or misreporting of the disease. Based on these current definitions, IMD reported incidence remains low across the region, with historical outbreaks mainly occurring due to the Hajj and Umrah mass gatherings. The use of case confirmation techniques also varies in Middle Eastern countries. While typical microbiological techniques, such as culture and Gram staining, are widely used for characterisation, polymerase chain reaction (PCR) testing is utilised in a small number of countries. PCR testing may be inaccessible for several reasons including sample transportation, cost, or a lack of laboratory expertise. These barriers, not exclusive to PCR use, may impact surveillance systems more broadly. Another concern throughout the region is potentially widespread ciprofloxacin resistance since its use for chemoprophylaxis remains high in many countries.
    MeSH term(s) Humans ; Meningococcal Infections/epidemiology ; Meningococcal Infections/prevention & control ; Meningococcal Infections/microbiology ; Neisseria meningitidis/genetics ; Middle East/epidemiology ; Disease Outbreaks/prevention & control ; Incidence ; Meningococcal Vaccines ; Serogroup
    Chemical Substances Meningococcal Vaccines
    Language English
    Publishing date 2023-10-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2023.10.011
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  5. Article ; Online: Meningococcal pneumonia.

    Vossen, Matthias / Mitteregger, Dieter / Steininger, Christoph

    Vaccine

    2016  Volume 34, Issue 37, Page(s) 4364–4370

    Abstract: ... manifestation of invasive meningococcal disease (excluding systemic sepsis) is meningococcal pneumonia ... Neisseria meningitidis remains the most important cause of bacterial meningitis worldwide ... It occurs in between 5% and 15% of all patients with invasive meningococcal disease and is thus the second ...

    Abstract Neisseria meningitidis remains the most important cause of bacterial meningitis worldwide, particularly in children and young adults. The second most common and a potentially severe end-organ manifestation of invasive meningococcal disease (excluding systemic sepsis) is meningococcal pneumonia. It occurs in between 5% and 15% of all patients with invasive meningococcal disease and is thus the second most common non-systemic end-organ manifestation. To establish the diagnosis requires a high level of clinical awareness - the incidence is therefore very likely underreported and underestimated. This review of 344 meningococcal pneumonia cases reported in the Americas, Europe, Australia, and Asia between 1906 and 2015 presents risk factors, pathogenesis, clinical manifestations, diagnostic approaches, treatment, and prognosis of meningococcal pneumonia.
    MeSH term(s) Humans ; Incidence ; Meningococcal Infections/epidemiology ; Neisseria meningitidis ; Pneumonia, Bacterial/epidemiology ; Pneumonia, Bacterial/microbiology ; Risk Factors
    Language English
    Publishing date 2016-08-17
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2016.07.013
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  6. Article: Serogroup B Meningococcal Sepsis and Meningitis Associated With Meningococcal Acute Otitis Media, and Paranasal Sinusitis in an Infant: A Case Report.

    Chacon-Cruz, Enrique / Lopatynsky, Erika Z

    Cureus

    2023  Volume 15, Issue 5, Page(s) e38430

    Abstract: ... manifests with high fever, with signs and symptoms of severe septicemia with or without purpura, and in more ... Meningococcal disease (MD) is a potentially lethal condition. Typically, following infection, MD ...

    Abstract Meningococcal disease (MD) is a potentially lethal condition. Typically, following infection, MD manifests with high fever, with signs and symptoms of severe septicemia with or without purpura, and in more than half of cases with meningitis. Acute otitis media (AOM) caused by
    Language English
    Publishing date 2023-05-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.38430
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  7. Article: Meningococcal sepsis.

    Rajapaksa, Shabna / Starr, Mike

    Australian family physician

    2010  Volume 39, Issue 5, Page(s) 276–278

    Abstract: ... This article presents a guide to identifying the salient features of meningococcal sepsis and initial ... Background: Meningococcal disease remains a significant illness with an overall mortality ... Missing a diagnosis of meningococcal disease is a fear among health care practitioners.: Objective ...

    Abstract Background: Meningococcal disease remains a significant illness with an overall mortality of around 8%. The majority of deaths occur in the first 24 hours, before the commencement of specialist care. Missing a diagnosis of meningococcal disease is a fear among health care practitioners.
    Objective: This article presents a guide to identifying the salient features of meningococcal sepsis and initial management strategies in the primary care setting.
    Discussion: Initial presentation is often nonspecific and therefore it is important to have a high index of suspicion in children presenting with fever, lethargy, myalgia, vomiting and headache. These children should be monitored and reviewed carefully. If a nonblanching rash develops, immediate treatment, liaison with a paediatric intensive care unit and urgent hospital transfer is required. Initial management involves assessment and regular review of airway, breathing and circulation. Antibiotics (preferably intravenous cephalosporin) should be administered before hospital transfer.
    MeSH term(s) Adult ; Anti-Bacterial Agents/therapeutic use ; Bacteremia/diagnosis ; Bacteremia/mortality ; Bacteremia/therapy ; Child ; Child, Preschool ; Combined Modality Therapy ; Critical Illness/therapy ; Early Diagnosis ; Emergency Treatment/methods ; Family Practice/standards ; Family Practice/trends ; Female ; Humans ; Infant ; Male ; Meningitis, Meningococcal/diagnosis ; Meningitis, Meningococcal/mortality ; Meningitis, Meningococcal/therapy ; Meningococcal Infections/diagnosis ; Meningococcal Infections/mortality ; Meningococcal Infections/therapy ; Monitoring, Physiologic/methods ; Practice Guidelines as Topic ; Prognosis ; Survival Analysis
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2010-05
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 423718-3
    ISSN 0300-8495
    ISSN 0300-8495
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  8. Article: Terminal Complement Pathway Deficiency in an Adult Patient with Meningococcal Sepsis.

    Staels, F / Meersseman, W / Stordeur, P / Willekens, K / Van Loo, S / Corveleyn, A / Meyts, I / Meyfroidt, G / Schrijvers, R

    Case reports in immunology

    2022  Volume 2022, Page(s) 9057000

    Abstract: ... meningococcal disease (IMD). However, IMD can also be a first manifestation in adulthood and should prompt ...

    Abstract The complement system is an essential part of our innate immune system. Three enzymatic activation pathways are described, all converging into a common terminal pathway which causes lysis of the target cell. Late complement deficiencies (LCDs) are typically diagnosed in children or adolescents with invasive meningococcal disease (IMD). However, IMD can also be a first manifestation in adulthood and should prompt for the evaluation of the LCD. We report the case of a young adult with IMD who was found to have a LCD, caused by a compound heterozygous mutation in
    Language English
    Publishing date 2022-05-23
    Publishing country Egypt
    Document type Case Reports
    ZDB-ID 2695564-7
    ISSN 2090-6617 ; 2090-6609
    ISSN (online) 2090-6617
    ISSN 2090-6609
    DOI 10.1155/2022/9057000
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  9. Article ; Online: A TRANSCRIPTOMIC APPRECIATION OF CHILDHOOD MENINGOCOCCAL AND POLYMICROBIAL SEPSIS FROM A PRO-INFLAMMATORY AND TRAJECTORIAL PERSPECTIVE, A ROLE FOR VASCULAR ENDOTHELIAL GROWTH FACTOR A AND B MODULATION?

    Rashid, Asrar / Brusletto, Berit S / Al-Obeidat, Feras / Toufiq, Mohammed / Benakatti, Govind / Brierley, Joe / Malik, Zainab A / Hussain, Zain / Alkhazaimi, Hoda / Sharief, Javed / Kadwa, Raziya / Sarpal, Amrita / Chaussabe, Damien / Malik, Rayaz A / Quraishi, Nasir / Khilnani, Praveen / Zaki, Syed A / Nadeem, Rashid / Shaikh, Guftar /
    Al-Dubai, Ahmed / Hafez, Wael / Hussain, Amir

    Shock (Augusta, Ga.)

    2023  Volume 60, Issue 4, Page(s) 503–516

    Abstract: Abstract: This study investigated the temporal dynamics of childhood sepsis by analyzing ... sepsis shock (MSS) datasets (two temporal and two longitudinal) and one polymicrobial sepsis dataset, were ... phases: early, intermediate, and late, providing a framework for understanding sepsis progression ...

    Abstract Abstract: This study investigated the temporal dynamics of childhood sepsis by analyzing gene expression changes associated with proinflammatory processes. Five datasets, including four meningococcal sepsis shock (MSS) datasets (two temporal and two longitudinal) and one polymicrobial sepsis dataset, were selected to track temporal changes in gene expression. Hierarchical clustering revealed three temporal phases: early, intermediate, and late, providing a framework for understanding sepsis progression. Principal component analysis supported the identification of gene expression trajectories. Differential gene analysis highlighted consistent upregulation of vascular endothelial growth factor A (VEGF-A) and nuclear factor κB1 (NFKB1), genes involved in inflammation, across the sepsis datasets. NFKB1 gene expression also showed temporal changes in the MSS datasets. In the postmortem dataset comparing MSS cases to controls, VEGF-A was upregulated and VEGF-B downregulated. Renal tissue exhibited higher VEGF-A expression compared with other tissues. Similar VEGF-A upregulation and VEGF-B downregulation patterns were observed in the cross-sectional MSS datasets and the polymicrobial sepsis dataset. Hexagonal plots confirmed VEGF-R (VEGF receptor)-VEGF-R2 signaling pathway enrichment in the MSS cross-sectional studies. The polymicrobial sepsis dataset also showed enrichment of the VEGF pathway in septic shock day 3 and sepsis day 3 samples compared with controls. These findings provide unique insights into the dynamic nature of sepsis from a transcriptomic perspective and suggest potential implications for biomarker development. Future research should focus on larger-scale temporal transcriptomic studies with appropriate control groups and validate the identified gene combination as a potential biomarker panel for sepsis.
    MeSH term(s) Humans ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism ; Transcriptome ; Vascular Endothelial Growth Factor B ; Cross-Sectional Studies ; Sepsis/genetics ; Biomarkers
    Chemical Substances Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factor B ; Biomarkers
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1185432-7
    ISSN 1540-0514 ; 1073-2322
    ISSN (online) 1540-0514
    ISSN 1073-2322
    DOI 10.1097/SHK.0000000000002192
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  10. Article ; Online: Meningococcal Vaccination:: An Update on Meningococcal Vaccine Recommendations for the Primary Care Physician.

    Nichols, Justin / Eppes, Stephen

    Delaware journal of public health

    2022  Volume 8, Issue 1, Page(s) 76–78

    Abstract: ... of meningitis and sepsis in the United States. Particularly at-risk groups include those with complement ... Neisseria meningitidis is an aerobic, gram-negative, diplococcus bacterium that is a leading cause ... meningococcal vaccines (Serogroups A, C, W, Y) and two recombinant serogroup B vaccines available for use ...

    Abstract Neisseria meningitidis is an aerobic, gram-negative, diplococcus bacterium that is a leading cause of meningitis and sepsis in the United States. Particularly at-risk groups include those with complement deficiencies, people using complement inhibitors, individuals with anatomic or functional asplenia, patients with HIV infection and travelers to endemic countries. There are currently three quadrivalent meningococcal vaccines (Serogroups A, C, W, Y) and two recombinant serogroup B vaccines available for use in the United States, and recommendations for vaccine use have changed rapidly in the past 10-15 years. This article summarizes updated ACIP recommendations for meningococcal vaccination for the primary care provider.
    Language English
    Publishing date 2022-03-29
    Publishing country United States
    Document type Journal Article
    ISSN 2639-6378
    ISSN (online) 2639-6378
    DOI 10.32481/djph.2022.03.012
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