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Article ; Online: Cutaneous manifestations of patients hospitalized with coronavirus disease 2019 (COVID-19).

Ramezani Darmian, P / Memarzadeh, Z / Aryan, R / Nahidi, Y / Mehri, Z / Taghipour, A / Samimi, N / Amini, M / Layegh, P

Journal of the European Academy of Dermatology and Venereology : JEADV

2021 Volume 35, Issue 12, Page(s) e837–e839

MeSH term(s)	COVID-19 ; Humans ; SARS-CoV-2 ; Skin Diseases, Viral
Language	English
Publishing date	2021-08-11
Publishing country	England
Document type	Letter
ZDB-ID	1128828-0
ISSN	1468-3083 ; 0926-9959
ISSN (online)	1468-3083
ISSN	0926-9959
DOI	10.1111/jdv.17557
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Article ; Online: Cutaneous manifestations of Coronavirus Disease 2019.

Ghafoor, Rabia / Ali, Syeda Mahanum / Goldust, Mohamad

Journal of cosmetic dermatology

2022 Volume 21, Issue 9, Page(s) 3667–3672

Abstract: ... To determine the presence of various cutaneous manifestations in patients with COVID-19, also to define ... assessed patients for COVID-related skin conditions. COVID-19 severity was categorized as asymptomatic/mild ... moderate, or severe.: Results: Of the 102 (85.7%) patients with only one cutaneous sign, 26.5% developed ...

Abstract	Background: COVID-19 has been linked to a variety of dermatological conditions. Objective: To determine the presence of various cutaneous manifestations in patients with COVID-19, also to define their features in relation to the systemic symptoms. Methods: This research enrolled a total of 1206 lab-confirmed COVID-19 individuals at a tertiary-care hospital in Karachi, Pakistan. Expert dermatologists assessed patients for COVID-related skin conditions. COVID-19 severity was categorized as asymptomatic/mild, moderate, or severe. Results: Of the 102 (85.7%) patients with only one cutaneous sign, 26.5% developed maculopapular/morbiliform/erythematous rash; 14.7% urticaria; 9.85% vesicular/pustular exanthem; 14.7% vascular pattern; 12.7% infections, 7.8% miscellaneous and 9.8% late cutaneous findings A longer-lasting vascular pattern was related with an older age and a fatal COVID-19 outcomes (P: 0.000) compared with mild/moderate disease. Most of the retiform purpura presented exclusively with thromboembolic episodes. The moderate severity was correlated with maculopapular/morbiliform/exanthematous phenotype (P: 0.009), whereas urticaria was attributed to asymptomatic/mild disease (0.001) compared with moderate/severe infection. Limitations: Single-Center and observational study. Conclusion: Vascular lesions were correlated with disastrous COVID-19 outcomes, whereas retiform purpura was linked to adverse outcomes. The maculopapular/morbiliform/erythematous rash was associated with moderate severity, while the urticarial rash was linked to milder course compared with moderate/severe severity infection.
MeSH term(s)	COVID-19/complications ; Drug Eruptions ; Exanthema/diagnosis ; Exanthema/etiology ; Humans ; Purpura ; SARS-CoV-2 ; Urticaria/etiology
Language	English
Publishing date	2022-08-09
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.15258
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Article ; Online: Cutaneous manifestations of coronavirus disease 2019 patients in Japan.

Tamai, Masakazu / Sakamoto, Rika / Goto, Noriko / Morimura, Osamu / Nishida, Tsutomu / Iwahashi, Hiromi / Yokomi, Akinori

The Journal of dermatology

2022 Volume 49, Issue 9, Page(s) 872–878

Abstract: Some patients with coronavirus disease 2019 (COVID-19) develop skin manifestations. There may be ... are, however, few reports on skin manifestations in COVID-19 patients in Asia, including Japan ... of skin manifestations was 9 days. This study revealed that approximately 2-3% of Japanese patients with COVID-19 ...

Abstract	Some patients with coronavirus disease 2019 (COVID-19) develop skin manifestations. There may be regional and racial differences in the frequency and type of COVID-19-associated skin manifestations. There are, however, few reports on skin manifestations in COVID-19 patients in Asia, including Japan. We retrospectively investigated the frequency, type, and clinical course of skin manifestations in Japanese patients with COVID-19. From 22 February 2020 to 16 August 2021, 738 Japanese patients (median age 59 years, 55% male) with laboratory-confirmed COVID-19 on polymerase chain reaction or antigen tests were admitted to our hospital. We mainly admitted patients with mild to moderate severity who had symptoms such as cough, fever, and oxygen demand but did not require mechanical ventilation. A total of 2.8% (21/738) of the COVID-19 patients treated at our hospital were diagnosed with viral eruptions caused by COVID-19. Of the 21 patients, 19 developed erythematous papules, and two developed urticaria. There were no cases of pernio-like lesions, known as COVID toes. The median duration from the onset of other COVID-19 symptoms to the development of skin manifestations was 9 days. This study revealed that approximately 2-3% of Japanese patients with COVID-19 developed COVID-19-associated viral eruptions, most of which were erythematous papules.
MeSH term(s)	COVID-19/complications ; COVID-19/diagnosis ; COVID-19/epidemiology ; Female ; Humans ; Japan/epidemiology ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2 ; Skin Diseases/diagnosis
Language	English
Publishing date	2022-05-10
Publishing country	England
Document type	Journal Article
ZDB-ID	800103-0
ISSN	1346-8138 ; 0385-2407
ISSN (online)	1346-8138
ISSN	0385-2407
DOI	10.1111/1346-8138.16433
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Article ; Online: Cutaneous Manifestations of COVID-19 in the Inpatient Setting.

Do, Mytrang H / Stewart, Claire R / Harp, Joanna

Dermatologic clinics

2021 Volume 39, Issue 4, Page(s) 521–532

Abstract: Cutaneous findings have increasingly been reported in patients with coronavirus disease 2019 (COVID ... manifestations is valuable for physicians caring for patients hospitalized with COVID-19 and may help improve ... hospitalization. We also discuss other reported COVID-19 cutaneous manifestations such as Sweet's syndrome ...

Abstract	Cutaneous findings have increasingly been reported in patients with coronavirus disease 2019 (COVID-19). This review discusses associated skin findings in patients with COVID-19 in the inpatient setting, ranging from vasculopathy-related lesions associated with high hospitalization rate and poor prognosis to inflammatory vesicular and urticarial eruptions that are rarely associated with prolonged hospitalization. We also discuss other reported COVID-19 cutaneous manifestations such as Sweet's syndrome, purpuric eruptions, and Multisystem Inflammatory Syndrome in Children. Although the relationship between dermatologic changes and COVID-19 disease progression is not fully elucidated, familiarity with cutaneous manifestations is valuable for physicians caring for patients hospitalized with COVID-19 and may help improve disease recognition and care.
MeSH term(s)	Adult ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/pathology ; Chilblains/diagnosis ; Chilblains/etiology ; Child ; Exanthema/diagnosis ; Exanthema/etiology ; Humans ; Inpatients/statistics & numerical data ; Pityriasis Rosea/diagnosis ; Pityriasis Rosea/etiology ; Skin Diseases/diagnosis ; Skin Diseases/etiology ; Skin Diseases, Vascular/diagnosis ; Skin Diseases, Vascular/etiology ; Systemic Inflammatory Response Syndrome/complications ; Systemic Inflammatory Response Syndrome/diagnosis ; Systemic Inflammatory Response Syndrome/pathology ; Urticaria/diagnosis ; Urticaria/etiology
Language	English
Publishing date	2021-05-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	82798-8
ISSN	1558-0520 ; 0733-8635
ISSN (online)	1558-0520
ISSN	0733-8635
DOI	10.1016/j.det.2021.05.011
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Article: Cutaneous manifestations, viral load, and prognosis among hospitalised patients with COVID-19: a cohort study.

Wong, C S M / Hung, I F N / Kwan, M Y W / Chung, M M H / Chan, M W M / Cheng, A K C / Lau, Y M / Yeung, C K / Chan, H H L / Lau, C S

Hong Kong medical journal = Xianggang yi xue za zhi

2023 Volume 29, Issue 5, Page(s) 421–431

Abstract: ... the incidence of cutaneous manifestations among hospitalised patients with COVID-19 and investigated ... disease 2019 (COVID-19), which may facilitate early clinical diagnosis and management. This study explored ... adult patients admitted to a tertiary hospital for COVID-19 from July to September 2020. Clinical ...

Abstract	Introduction: Various cutaneous manifestations have been reported as symptoms of coronavirus disease 2019 (COVID-19), which may facilitate early clinical diagnosis and management. This study explored the incidence of cutaneous manifestations among hospitalised patients with COVID-19 and investigated its relationships with viral load, co-morbidities, and outcomes. Methods: This retrospective study included adult patients admitted to a tertiary hospital for COVID-19 from July to September 2020. Clinical information, co-morbidities, viral load (cycle threshold [Ct] value), and outcomes were analysed. Results: In total, 219 patients with confirmed COVID-19 were included. Twenty patients presented with new onset of rash. The incidence of new rash was 9.1% (95% confidence interval=6.25%-14.4%). The most common manifestations were maculopapular exanthem (n=6, 42.9%, median Ct value: 24.8), followed by livedo reticularis (n=4, 28.6%, median Ct value: 21.3), varicella-like lesions (n=2, 14.3%, median Ct value: 19.3), urticaria (n=1, 7.1%, median Ct value: 14.4), and acral chilblain and petechiae (n=1, 7.1%, median Ct value: 33.1). The median Ct values for patients with and without rash were 22.9 and 24.1, respectively (P=0.58). There were no significant differences in mortality or hospital stay between patients with and without rash. Patients with rash were more likely to display fever on admission (P<0.01). Regardless of cutaneous manifestations, patients with older age, hypertension, and chronic kidney disease stage ≥3 had significantly higher viral load and mortality (P<0.05). Conclusion: This study revealed no associations between cutaneous manifestation and viral load or clinical outcomes. Older patients with multiple co-morbidities have risks of high viral load and mortality; they should be closely monitored.
MeSH term(s)	Adult ; Humans ; COVID-19/complications ; SARS-CoV-2 ; Cohort Studies ; Viral Load ; Retrospective Studies ; Prognosis ; Exanthema
Language	English
Publishing date	2023-10-19
Publishing country	China
Document type	Journal Article
ZDB-ID	1239255-8
ISSN	1024-2708
ISSN	1024-2708
DOI	10.12809/hkmj2210199
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Zs.A 4347: Show issues

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Article ; Online: Cutaneous manifestations in an Italian military COVID hub.

Di Nunno, Donato / Laghi, Alessandro / Troiani, Giorgio / Marseglia, Bernardino / Anelli, Lorenzo / Farina, Elisa / Tarricone, Francesco / Mammana, Giacomo / Catalano, Carlo / Bonito, Alessandro / De Capua, Antonio / Caramanico, Guido / Blasioli, Sante / Astorino, Stefano

Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia

2020 Volume 155, Issue 5, Page(s) 632–635

Abstract: Background: The outbreak of the pandemic Coronavirus disease 2019 (COVID-19), caused by a novel ... the hospitalization due to COVID-19 and absent before.: Methods: All the SARS-CoV-2 positive patients hospitalized ... Conclusions: A deeper knowledge of cutaneous manifestations in military and civilian hospitalized COVID-19 ...

Abstract	Background: The outbreak of the pandemic Coronavirus disease 2019 (COVID-19), caused by a novel coronavirus named Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), affecting a high number of patients in Italy, forced a great number of doctors, even dermatologists, to work in the first lines in the dedicated departments. We analyzed the features and the incidence of dermatological issues emerged during the hospitalization due to COVID-19 and absent before. Methods: All the SARS-CoV-2 positive patients hospitalized in Celio Military Hospital - COVID hub no-intensive care wards from March 16, 2020 until May 4, 2020 were evaluated by dermatologists several times during the hospital stay. Results: Ninety-six patients (15 civilians and 81 Italian servicepeople) were enrolled: 34 (35.4%) patients developed cutaneous manifestations; 15 (16.0%) suffered from skin dryness; 5 (5.2%) irritant contact dermatitis; 4 (4.2%) seborrheic dermatitis; 4 (4.2%) morbilliform rashes; 3 (3.1%) petechial rashes and 3 (3.1%) widespread hives. Conclusions: A deeper knowledge of cutaneous manifestations in military and civilian hospitalized COVID-19 patients could suggest more effective treatments to win the battle against SARS-CoV-2.
MeSH term(s)	Adult ; Aged ; COVID-19/complications ; COVID-19/epidemiology ; Dermatitis/epidemiology ; Dermatitis/etiology ; Exanthema/epidemiology ; Exanthema/etiology ; Female ; Hospitals, Military/statistics & numerical data ; Humans ; Ichthyosis/epidemiology ; Ichthyosis/etiology ; Inpatients ; Italy/epidemiology ; Male ; Middle Aged ; Military Personnel ; Pandemics ; Psoriasis/complications ; SARS-CoV-2 ; Skin Diseases/epidemiology ; Skin Diseases/etiology ; Urticaria/epidemiology ; Urticaria/etiology ; Young Adult
Language	English
Publishing date	2020-12-07
Publishing country	Italy
Document type	Journal Article
ZDB-ID	604114-0
ISSN	1827-1820 ; 0026-4741 ; 0392-0488
ISSN (online)	1827-1820
ISSN	0026-4741 ; 0392-0488
DOI	10.23736/S0392-0488.20.06735-8
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Article: Cutaneous Manifestations Associated with COVID-19 Infection in a COVID-Designated Hospital in North Chennai - A Descriptive Cross-Sectional Study.

Kumar, Parimalam / Radha, Guru / Muthukrishnan, Madhanchand / Chandrasekaran, Balakumaran / Subbiah, Pravinkumar / Raman, Jagan

Indian dermatology online journal

2022 Volume 14, Issue 1, Page(s) 67–71

Abstract: Background: Coronavirus disease 2019 (COVID-19) affects different organ systems, including ... of reverse transcriptase polymerase chain reaction (RT-PCR)-positive COVID-19 patients in a COVID-designated tertiary care hospital. Approval was ... obtained from the Institutional Ethical Committee, and 5460 RT-PCR-confirmed COVID-19-positive patients ...

Abstract	Background: Coronavirus disease 2019 (COVID-19) affects different organ systems, including the skin. There are reports on cutaneous manifestations of COVID-19 available in the literature. In this study, we have tried to describe the dermatological signs of COVID-19 in different categories of patients. Materials and methods: A descriptive cross sectional study was conducted to describe various cutaneous manifestations of COVID-19 in different categories of reverse transcriptase polymerase chain reaction (RT-PCR)-positive COVID-19 patients in a COVID-designated tertiary care hospital. Approval was obtained from the Institutional Ethical Committee, and 5460 RT-PCR-confirmed COVID-19-positive patients were included under five categories. Investigators following a strict COVID protocol examined and documented the findings. Investigations and treatment were carried out as per the protocol, and the study was conducted for a period of 6 months. Results: Out of the 5460 patients studied, 1.9% patients had cutaneous manifestations. Vasculitis (24%) and maculo papular rash (19%) were the common findings. The incidence of vasculitis was 44.4%, 61%, and 6.6% in categories A, B, and C, respectively. Maculopapular rash and urticaria were the common findings in categories D and E, respectively. COVID digit was seen in only one case. Other manifestations such as acne, adverse drug reaction, erythroderma, and bullous disorders were also noted. Conclusion: Cutaneous manifestations because of vascular pathology were the most common association in severe COVID-19, which indicates that the presence of vasculitic skin signs correlated with disease severity and elevated d-dimer values. Urticaria and maculo-papular rash were transient and did not give any clue to the diagnosis or severity of the disease.
Language	English
Publishing date	2022-12-29
Publishing country	India
Document type	Journal Article
ZDB-ID	2585814-2
ISSN	2249-5673 ; 2229-5178
ISSN (online)	2249-5673
ISSN	2229-5178
DOI	10.4103/idoj.idoj_279_22
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Article: Retrospective View of Four Cases of Cutaneous Manifestations in COVID-19 Patients in an Acute Care Setting.

De Carvalho, Magali Rezende / Thomas, Elmira / Shields-Johnson, Barbara / Da Silva, Ivan

Cureus

2022 Volume 14, Issue 3, Page(s) e23003

Abstract: ... of coronavirus disease 2019 (COVID-19), causes an excessive inflammatory response and hemostatic abnormalities ... in the lungs, kidney, and skin. Four patients with COVID-19 admitted to an acute care community hospital ... hyperinflammation status and microthrombosis may be responsible for the cutaneous manifestations in patients ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the etiologic agent of coronavirus disease 2019 (COVID-19), causes an excessive inflammatory response and hemostatic abnormalities in the lungs, kidney, and skin. Four patients with COVID-19 admitted to an acute care community hospital developed nonblanchable purpuric macules, patches, and retiform purpura-like lesions at the sacrum, buttocks, lower extremities, and upper back. These lesions can be misdiagnosed as deep tissue pressure injuries. One patient also developed a vesicular-like rash at the upper back and another one developed pernio (chilblains)-like lesions to the third toe of the left foot. Previous studies suggest that the vascular hyperinflammation status and microthrombosis may be responsible for the cutaneous manifestations in patients with SARS-CoV-2. These cutaneous manifestations observed in patients with SARS-CoV-2 may be related to progression of the disease.
Language	English
Publishing date	2022-03-09
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.23003
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Article: Postoperative Cutaneous Manifestations as the First Presentation of COVID-19 Infection or a Postvaccination Sequel.

El Minawi, Hisham / Abdelgawad, Ahmed / El Saloussy, Yasmeen / Abdelgawad, Belal Ahmed

Plastic and reconstructive surgery. Global open

2022 Volume 10, Issue 2, Page(s) e4163

Abstract: Since its first emergence, coronavirus disease 2019 (COVID-19) took the world by surprise, causing ... signs of COVID-19 infection. Acquaintance with the cutaneous presentations of COVID-19 may help ... surgical interventions in which skin manifestations were the first indicators of COVID-19 infection or ...

Abstract	Since its first emergence, coronavirus disease 2019 (COVID-19) took the world by surprise, causing more than two million deaths and 100 million infections to date. The virus's most prevalent clinical symptoms have become well known, yet the rarer symptoms, on the other hand, need to be more widely recognized. Various studies have reflected the possibilities of potential skin lesions being the presenting signs of COVID-19 infection. Acquaintance with the cutaneous presentations of COVID-19 may help in early diagnosis and management of infected patients. Herein we report two cases that presented for plastic surgical interventions in which skin manifestations were the first indicators of COVID-19 infection or postvaccination sequel. The cases were operated upon in different hospitals by different surgical teams.
Language	English
Publishing date	2022-02-23
Publishing country	United States
Document type	Case Reports
ZDB-ID	2851682-5
ISSN	2169-7574 ; 2169-7574
ISSN (online)	2169-7574
ISSN	2169-7574
DOI	10.1097/GOX.0000000000004163
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Article ; Online: Cutaneous Manifestations of COVID-19: A Report from the United Arab Emirates.

Galadari, Ibrahim / Marzooqi, Amani Al / Naeem, Ayman Al / Ali, Suad / Adawi, Meera / Galadari, Hassan

Skinmed

2020 Volume 18, Issue 4, Page(s) 218–220

Abstract: Coronavirus disease of 2019 (COVID-19) is a viral infection caused ... of the disease. Forty-five (12.5%) patients had clearly identifiable cutaneous manifestation of COVID-19. Two ... A total of 324 patients with COVID-19 were identified and divided into three groups based on the severity ...

Abstract	Coronavirus disease of 2019 (COVID-19) is a viral infection caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). In addition to affecting mainly the respiratory tract, there have been many reported cutaneous manifestations of the disease. A retrospective case series based on history and clinical findings was performed across six hospitals in the UAE, including two field hospitals. A total of 324 patients with COVID-19 were identified and divided into three groups based on the severity of the disease. Forty-five (12.5%) patients had clearly identifiable cutaneous manifestation of COVID-19. Two patients each with alopecia areata and sclerosis of the extremities, respectively, were identified in the second group. Cutaneous manifestations of COVID-19 have been well reported across the literature. The experience in the UAE is similar to that of published reports. The occurrence of other cutaneous manifestations with an underlying autoimmune pathogenesis should raise the possibility of such conditions in those with COVID-19. (
MeSH term(s)	Adult ; Age Factors ; COVID-19 ; Cohort Studies ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Databases, Factual ; Female ; Humans ; Male ; Middle Aged ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Prevalence ; Retrospective Studies ; Risk Assessment ; Severity of Illness Index ; Sex Factors ; Skin Diseases, Viral/epidemiology ; Skin Diseases, Viral/physiopathology ; United Arab Emirates/epidemiology
Keywords	covid19
Language	English
Publishing date	2020-08-01
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Multicenter Study
ZDB-ID	2171125-2
ISSN	1751-7125 ; 1540-9740
ISSN (online)	1751-7125
ISSN	1540-9740
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