Article ; Online: Impact of diuretics on the urate lowering therapy in patients with gout: analysis of an inception cohort.
2018 Volume 20, Issue 1, Page(s) 53
Abstract: ... with gout. METHODS: This was a retrospective analysis of an inception cohort. Participants were classified ... The aim of the present study was to assess the impact of the diuretics on the response to ULD in patients ... Background: Diuretics have been associated with impaired response and refractoriness in gout ...
| Abstract | Background: Diuretics have been associated with impaired response and refractoriness in gout, but whether this effect is still present with new urate-lowering drugs (ULD) and treat-to-target strategies is unknown. The aim of the present study was to assess the impact of the diuretics on the response to ULD in patients with gout. METHODS: This was a retrospective analysis of an inception cohort. Participants were classified according to the type of ULD prescribed. We analysed the maximal dose of ULD (primary outcome variable), serum urate (SU) reduction, and the achievement of different SU targets (6 mg/dL, 5 mg/dL, and 4 mg/dL), according to the type of ULD prescribed and use of diuretics (loop and/or thiazide). We adjusted for confounders using multiple linear regression analysis. Results: We included 245 patients: 208 treated with allopurinol (66 on diuretics, 31.7%), 35 with febuxostat (19 on diuretics, 57.6%), and 2 with benzbromarone. Significantly fewer participants in the allopurinol plus diuretics subgroup achieved SU levels of less than 5 mg/dL, but we found no other significant differences in SU targets associated with diuretics. Regarding the maximum ULD dose, a simple linear regression suggested an inverse relationship with diuretics (beta = - 0.125, p = 0.073), but this did not hold in the multivariable analysis (beta = - 0.47, p = 0.833). There was no association with febuxostat (beta = - 0.116, p = 0.514). Conclusion: Diuretics do not appear to have a significant impact on managing gout. |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | Aged ; Aged, 80 and over ; Cohort Studies ; Diuretics/therapeutic use ; Female ; Follow-Up Studies ; Gout/blood ; Gout/diagnosis ; Gout/drug therapy ; Gout Suppressants/therapeutic use ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Treatment Outcome ; Uric Acid/blood | |||||
| Chemical Substances | Diuretics ; Gout Suppressants ; Uric Acid (268B43MJ25) | |||||
| Language | English | |||||
| Publishing date | 2018-03-22 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 2107602-9 | |||||
| ISSN | 1478-6362 ; 1478-6354 | |||||
| ISSN (online) | 1478-6362 | |||||
| ISSN | 1478-6354 | |||||
| DOI | 10.1186/s13075-018-1559-2 | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 5490: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.