Article: Effect of Systemic Antioxidant Allopurinol Therapy on Skin Flap Survival.
World journal of plastic surgery
2017 Volume 6, Issue 1, Page(s) 54–61
Abstract: ... cell survival. This study was aimed to evaluate effects of allopurinol on skin flaps in dogs.: Methods ... Conclusion: It was demonstrated that systemic administration of allopurinol significantly improved skin flap ... Twenty dogs underwent one skin flap surgery with a 2-week interval. The first procedure was performed ...
| Abstract | Background: It has been reported that systemic administration of allopurinol improves cell survival. This study was aimed to evaluate effects of allopurinol on skin flaps in dogs. Methods: Twenty dogs underwent one skin flap surgery with a 2-week interval. The first procedure was performed according to the standard protocols. The second phase was started by a 1-week pretreatment with allopurinol. Length of the necrotic zone was measured and recorded daily. At each phase, flaps were removed and sent for histopathological study after 1 week observation. Results: Mean length of the necrotic zone in allopurinol treated skin flaps has been significantly less than normal flaps over all 7 days of observation ( Conclusion: It was demonstrated that systemic administration of allopurinol significantly improved skin flap survival. |
|---|---|
| Language | English |
| Publishing date | 2017-02-28 |
| Publishing country | Iran |
| Document type | Journal Article |
| ZDB-ID | 2781494-4 |
| ISSN | 2252-0724 ; 2228-7914 |
| ISSN (online) | 2252-0724 |
| ISSN | 2228-7914 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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