Article ; Online: SARS-CoV-2 Seroprevalence and Clinical Features of COVID-19 in a German Liver Transplant Recipient Cohort: A Prospective Serosurvey Study.
2020 Volume 53, Issue 4, Page(s) 1112–1117
Abstract: ... of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serosurvey in a large LT recipient cohort.: Methods: A total of 219 ... Background: In liver transplant (LT) recipients with severe coronavirus disease 2019 (COVID-19 ... recipients a priori represented a high-risk cohort for severe COVID-19 with 101 of 219 (46.1%) presenting ...
| Abstract | Background: In liver transplant (LT) recipients with severe coronavirus disease 2019 (COVID-19), fatal outcome has been reported in a substantial subset of patients. Whether LT recipients are at increased risk for severe COVID-19 compared with the general population is controversial. Here we report the results of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serosurvey in a large LT recipient cohort. Methods: A total of 219 LT recipients were enrolled between May 5, 2020, and August 6, 2020, at the University Hospital Heidelberg. Serum blood samples were collected and tested for anti-SARS-CoV-2 IgG. SARS-CoV-2 RNA was detected in nasopharyngeal swabs using reverse transcription-polymerase chain reaction assays. Results: Taking into account known risk factors of arterial hypertension, obesity, diabetes, or leukopenia, LT recipients a priori represented a high-risk cohort for severe COVID-19 with 101 of 219 (46.1%) presenting with more than 2 risk factors for severe COVID-19. Out of 219 LT recipients, 8 (3.7%) either had a positive test result for nasopharyngeal SARS-CoV-2 RNA or anti-SARS-CoV-2 serum IgG. Five of eight (62.5%) did not show any clinical signs of infection, three of eight (37.5%) had self-limited disease, and none required hospitalization for COVID-19. Two of eight (25%) had known exposure to infected health care staff as the probable source of infection. Conclusions: In summary, LT recipients showed a SARS-CoV-2 seroconversion rate similar to that of the general population with a substantial percentage of unrecognized infections. |
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| MeSH term(s) | Adult ; Antibodies, Viral/blood ; COVID-19/epidemiology ; COVID-19/immunology ; Female ; Germany/epidemiology ; Humans ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Liver Transplantation/adverse effects ; Male ; Middle Aged ; Postoperative Complications/epidemiology ; Postoperative Complications/immunology ; Prospective Studies ; RNA, Viral/blood ; Risk Factors ; SARS-CoV-2/immunology ; Seroconversion ; Seroepidemiologic Studies |
| Chemical Substances | Antibodies, Viral ; Immunoglobulin G ; RNA, Viral |
| Language | English |
| Publishing date | 2020-12-16 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 82046-5 |
| ISSN | 1873-2623 ; 0041-1345 |
| ISSN (online) | 1873-2623 |
| ISSN | 0041-1345 |
| DOI | 10.1016/j.transproceed.2020.11.009 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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