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Article ; Online: COVID-19 and the potential long term impact on antimicrobial resistance

Rawson, TM / Moore, L / Castro Sanchez, E / Charani, E / Davies, F / Satta, G / Ellington, M / Holmes, A

1684 ; 1681

2020

Abstract: ... of these changes will have a net-positive or -negative impact on rates of antimicrobial resistance ... society on the threat of emerging infections and hand hygiene, certain infection control and antimicrobial ... threat of antimicrobial resistance should not be overlooked. ...

Abstract	The emergence of the SARS-CoV-2 respiratory virus has required an unprecedented response to control the spread of the infection and protect the most vulnerable within society. Whilst the pandemic has focused society on the threat of emerging infections and hand hygiene, certain infection control and antimicrobial stewardship policies may have to be relaxed. It is unclear whether the unintended consequences of these changes will have a net-positive or -negative impact on rates of antimicrobial resistance. Whilst the urgent focus must be on allaying this pandemic, sustained efforts to address the longer-term global threat of antimicrobial resistance should not be overlooked.
Keywords	Antimicrobial Stewardship ; Betacoronavirus ; Coronavirus Infections ; Delivery of Health Care ; Drug Resistance ; Microbial ; Hand Hygiene ; Humans ; Infection Control ; Pandemics ; Patient Isolation ; Pneumonia ; Viral ; 0605 Microbiology ; 1108 Medical Microbiology ; 1115 Pharmacology and Pharmaceutical Sciences ; Microbiology ; covid19
Publishing date	2020-04-22
Publisher	Oxford University Press (OUP)
Publishing country	uk
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: COVID-19 and the potential long-term impact on antimicrobial resistance.

Rawson, Timothy M / Moore, Luke S P / Castro-Sanchez, Enrique / Charani, Esmita / Davies, Frances / Satta, Giovanni / Ellington, Matthew J / Holmes, Alison H

The Journal of antimicrobial chemotherapy

2020 Volume 75, Issue 7, Page(s) 1681–1684

Abstract: ... the longer-term global threat of antimicrobial resistance should not be overlooked. ... infection control and antimicrobial stewardship policies may have to be relaxed. It is unclear ... of antimicrobial resistance. Whilst the urgent focus must be on controlling this pandemic, sustained efforts to address ...

Abstract	The emergence of the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) has required an unprecedented response to control the spread of the infection and protect the most vulnerable within society. Whilst the pandemic has focused society on the threat of emerging infections and hand hygiene, certain infection control and antimicrobial stewardship policies may have to be relaxed. It is unclear whether the unintended consequences of these changes will have a net-positive or -negative impact on rates of antimicrobial resistance. Whilst the urgent focus must be on controlling this pandemic, sustained efforts to address the longer-term global threat of antimicrobial resistance should not be overlooked.
MeSH term(s)	Antimicrobial Stewardship/organization & administration ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/prevention & control ; Coronavirus Infections/therapy ; Delivery of Health Care/organization & administration ; Drug Resistance, Microbial ; Hand Hygiene ; Humans ; Infection Control/methods ; Pandemics/prevention & control ; Patient Isolation ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/therapy ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-05-20
Publishing country	England
Document type	Journal Article
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkaa194
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Article ; Online: It is complicated: Potential short- and long-term impact of coronavirus disease 2019 (COVID-19) on antimicrobial resistance-An expert review.

Seneghini, Marco / Rüfenacht, Susanne / Babouee-Flury, Baharak / Flury, Domenica / Schlegel, Matthias / Kuster, Stefan P / Kohler, Philipp P

Antimicrobial stewardship & healthcare epidemiology : ASHE

2022 Volume 2, Issue 1, Page(s) e27

Abstract: ... effects of COVID-19 on antimicrobial resistance (AMR), which was already a global threat before the pandemic, are ... of deaths and caused disruptions in health systems around the world. The short- and long-term ... local mobility) and which additional factors might play a role in the long term. Whereas reduced ...

Abstract	As of December 2021, the coronavirus disease 2019 (COVID-19) pandemic has claimed millions of deaths and caused disruptions in health systems around the world. The short- and long-term effects of COVID-19 on antimicrobial resistance (AMR), which was already a global threat before the pandemic, are manifold and complex. In this expert review, we summarize how COVID-19 might be affecting AMR in the short term (by influencing the key determinants antibiotic use, infection control practices and international/local mobility) and which additional factors might play a role in the long term. Whereas reduced outpatient antibiotic use in high-income countries, increased awareness for hand hygiene, and reduced mobility have likely mitigated the emergence and spread of AMR in the short term, factors such as overuse of antibiotics in COVID-19 patients, shortage of personal protective equipment, lack of qualified healthcare staff, and patient overcrowding have presumably facilitated its propagation. Unsurprisingly, international and national AMR surveillance data for 2020 show ambiguous trends. Although disruptions in antibiotic stewardship programs, AMR surveillance and research might promote the spread of AMR, other developments could prove beneficial to the cause in the long term. These factors include the increased public awareness for infectious diseases and infection control issues, the strengthening of the One Health perspective as outlined by the Centers for Disease Control and Prevention, and the unprecedented number of international research collaborations and platforms. These factors could even serve as leverage and provide opportunities to better combat AMR in the future.
Language	English
Publishing date	2022-02-18
Publishing country	England
Document type	Journal Article ; Review
ISSN	2732-494X
ISSN (online)	2732-494X
DOI	10.1017/ash.2022.10
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: COVID-19 and the potential long-term impact on antimicrobial resistance

Rawson, Timothy M / Moore, Luke S P / Castro-Sanchez, Enrique / Charani, Esmita / Davies, Frances / Satta, Giovanni / Ellington, Matthew J / Holmes, Alison H

J Antimicrob Chemother

Abstract	The emergence of the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) has required an unprecedented response to control the spread of the infection and protect the most vulnerable within society. Whilst the pandemic has focused society on the threat of emerging infections and hand hygiene, certain infection control and antimicrobial stewardship policies may have to be relaxed. It is unclear whether the unintended consequences of these changes will have a net-positive or -negative impact on rates of antimicrobial resistance. Whilst the urgent focus must be on controlling this pandemic, sustained efforts to address the longer-term global threat of antimicrobial resistance should not be overlooked.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #324273
Database	COVID19

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Article ; Online: COVID-19 and the potential long-term impact on antimicrobial resistance

Rawson, Timothy M / Moore, Luke S P / Castro-Sanchez, Enrique / Charani, Esmita / Davies, Frances / Satta, Giovanni / Ellington, Matthew J / Holmes, Alison H

Journal of Antimicrobial Chemotherapy

2020 Volume 75, Issue 7, Page(s) 1681–1684

Abstract: ... the longer-term global threat of antimicrobial resistance should not be overlooked. ... certain infection control and antimicrobial stewardship policies may have to be relaxed. It is unclear ... of antimicrobial resistance. Whilst the urgent focus must be on controlling this pandemic, sustained efforts to address ...

Abstract	Abstract The emergence of the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) has required an unprecedented response to control the spread of the infection and protect the most vulnerable within society. Whilst the pandemic has focused society on the threat of emerging infections and hand hygiene, certain infection control and antimicrobial stewardship policies may have to be relaxed. It is unclear whether the unintended consequences of these changes will have a net-positive or -negative impact on rates of antimicrobial resistance. Whilst the urgent focus must be on controlling this pandemic, sustained efforts to address the longer-term global threat of antimicrobial resistance should not be overlooked.
Keywords	Pharmacology (medical) ; Pharmacology ; Infectious Diseases ; covid19
Language	English
Publisher	Oxford University Press (OUP)
Publishing country	uk
Document type	Article ; Online
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkaa194
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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In stock of ZB MED Cologne/Königswinter

Zs.A 1197: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 124: Show issues

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Article ; Online: COVID-19 and the potential long-term impact on antimicrobial resistance

Rawson, T. M. / Moore, L. S. P. / Castro-Sanchez, E. / Charani, E. / Davies, F. / Satta, G. / Ellington, M. J. / Holmes, A. H.

2020

Abstract	The emergence of the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) has required an unprecedented response to control the spread of the infection and protect the most vulnerable within society. Whilst the pandemic has focused society on the threat of emerging infections and hand hygiene, certain infection control and antimicrobial stewardship policies may have to be relaxed. It is unclear whether the unintended consequences of these changes will have a net-positive or -negative impact on rates of antimicrobial resistance. Whilst the urgent focus must be on controlling this pandemic, sustained efforts to address the longer-term global threat of antimicrobial resistance should not be overlooked.
Keywords	HN Social history and conditions. Social problems. Social reform ; QR180 Immunology ; RA0421 Public health. Hygiene. Preventive Medicine ; covid19
Language	English
Publishing date	2020-05-20
Publisher	Oxford University Press
Publishing country	uk
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The Hidden Cost of COVID-19: Focus on Antimicrobial Resistance in Bloodstream Infections.

Micheli, Giulia / Sangiorgi, Flavio / Catania, Francesca / Chiuchiarelli, Marta / Frondizi, Federico / Taddei, Eleonora / Murri, Rita

Microorganisms

2023 Volume 11, Issue 5

Abstract: ... procedures with a potential long-term impact on AMR. Still, COVID-19-related measures such as increasing ... of antimicrobial resistance in the COVID-19 era with a focus on bloodstream infections and provides insights ... from existing programs and reducing funding for antimicrobial resistance (AMR) fighting efforts. Moreover ...

Abstract	Antibiotic resistance is one of the greatest growing public health threats and a worldwide priority. According to the WHO, drug-resistant diseases may cause 10 million deaths a year by 2050 and have a substantial impact on the global economy, driving up to 24 million people into poverty. The ongoing COVID-19 pandemic has exposed the fallacies and vulnerability of healthcare systems worldwide, displacing resources from existing programs and reducing funding for antimicrobial resistance (AMR) fighting efforts. Moreover, as already seen for other respiratory viruses, such as flu, COVID-19 is often associated with superinfections, prolonged hospital stays, and increased ICU admissions, further aggravating healthcare disruption. These events are accompanied by widespread antibiotic use, misuse, and inappropriate compliance with standard procedures with a potential long-term impact on AMR. Still, COVID-19-related measures such as increasing personal and environmental hygiene, social distancing, and decreasing hospital admissions could theoretically help the AMR cause. However, several reports have shown increased antimicrobial resistance during the COVID-19 pandemic. This narrative review focuses on this "twindemic", assessing the current knowledge of antimicrobial resistance in the COVID-19 era with a focus on bloodstream infections and provides insights into the lessons learned in the COVID-19 field that could be applied to antimicrobial stewardship initiatives.
Language	English
Publishing date	2023-05-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11051299
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Shaping the subway microbiome through probiotic-based sanitation during the COVID-19 emergency: a pre-post case-control study.

D'Accolti, Maria / Soffritti, Irene / Bini, Francesca / Mazziga, Eleonora / Cason, Carolina / Comar, Manola / Volta, Antonella / Bisi, Matteo / Fumagalli, Daniele / Mazzacane, Sante / Caselli, Elisabetta

Microbiome

2023 Volume 11, Issue 1, Page(s) 64

Abstract: ... the microbiome of treated environments, providing effective and long-term control of pathogens and AMR spread ... environmental impact, potentially enhancing antimicrobial resistance (AMR) of the treated microbes. By contrast ... the applicability and impact of PBS compared with chemical disinfectants based on their effects on the surface ...

Abstract	Background: The COVID-19 pandemic has highlighted the extent to which the public transportation environment, such as in subways, may be important for the transmission of potential pathogenic microbes among humans, with the possibility of rapidly impacting large numbers of people. For these reasons, sanitation procedures, including massive use of chemical disinfection, were mandatorily introduced during the emergency and remain in place. However, most chemical disinfectants have temporary action and a high environmental impact, potentially enhancing antimicrobial resistance (AMR) of the treated microbes. By contrast, a biological and eco-sustainable probiotic-based sanitation (PBS) procedure was recently shown to stably shape the microbiome of treated environments, providing effective and long-term control of pathogens and AMR spread in addition to activity against SARS-CoV-2, the causative agent of COVID-19. Our study aims to assess the applicability and impact of PBS compared with chemical disinfectants based on their effects on the surface microbiome of a subway environment. Results: The train microbiome was characterized by both culture-based and culture-independent molecular methods, including 16S rRNA NGS and real-time qPCR microarray, for profiling the train bacteriome and its resistome and to identify and quantify specific human pathogens. SARS-CoV-2 presence was also assessed in parallel using digital droplet PCR. The results showed a clear and significant decrease in bacterial and fungal pathogens (p < 0.001) as well as of SARS-CoV-2 presence (p < 0.01), in the PBS-treated train compared with the chemically disinfected control train. In addition, NGS profiling evidenced diverse clusters in the population of air vs. surface while demonstrating the specific action of PBS against pathogens rather than the entire train bacteriome. Conclusions: The data presented here provide the first direct assessment of the impact of different sanitation procedures on the subway microbiome, allowing a better understanding of its composition and dynamics and showing that a biological sanitation approach may be highly effective in counteracting pathogens and AMR spread in our increasingly urbanized and interconnected environment. Video Abstract.
MeSH term(s)	Humans ; COVID-19 ; Railroads ; SARS-CoV-2/genetics ; Sanitation/methods ; RNA, Ribosomal, 16S/genetics ; Pandemics/prevention & control ; Case-Control Studies ; Microbiota ; Probiotics ; Disinfectants/pharmacology
Chemical Substances	RNA, Ribosomal, 16S ; Disinfectants
Language	English
Publishing date	2023-03-30
Publishing country	England
Document type	Video-Audio Media ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2697425-3
ISSN	2049-2618 ; 2049-2618
ISSN (online)	2049-2618
ISSN	2049-2618
DOI	10.1186/s40168-023-01512-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Shaping the subway microbiome through probiotic-based sanitation during the COVID-19 emergency

Maria D’Accolti / Irene Soffritti / Francesca Bini / Eleonora Mazziga / Carolina Cason / Manola Comar / Antonella Volta / Matteo Bisi / Daniele Fumagalli / Sante Mazzacane / Elisabetta Caselli

Microbiome, Vol 11, Iss 1, Pp 1-

a pre–post case–control study

2023 Volume 19

Abstract	Abstract Background The COVID-19 pandemic has highlighted the extent to which the public transportation environment, such as in subways, may be important for the transmission of potential pathogenic microbes among humans, with the possibility of rapidly impacting large numbers of people. For these reasons, sanitation procedures, including massive use of chemical disinfection, were mandatorily introduced during the emergency and remain in place. However, most chemical disinfectants have temporary action and a high environmental impact, potentially enhancing antimicrobial resistance (AMR) of the treated microbes. By contrast, a biological and eco-sustainable probiotic-based sanitation (PBS) procedure was recently shown to stably shape the microbiome of treated environments, providing effective and long-term control of pathogens and AMR spread in addition to activity against SARS-CoV-2, the causative agent of COVID-19. Our study aims to assess the applicability and impact of PBS compared with chemical disinfectants based on their effects on the surface microbiome of a subway environment. Results The train microbiome was characterized by both culture-based and culture-independent molecular methods, including 16S rRNA NGS and real-time qPCR microarray, for profiling the train bacteriome and its resistome and to identify and quantify specific human pathogens. SARS-CoV-2 presence was also assessed in parallel using digital droplet PCR. The results showed a clear and significant decrease in bacterial and fungal pathogens (p < 0.001) as well as of SARS-CoV-2 presence (p < 0.01), in the PBS-treated train compared with the chemically disinfected control train. In addition, NGS profiling evidenced diverse clusters in the population of air vs. surface while demonstrating the specific action of PBS against pathogens rather than the entire train bacteriome. Conclusions The data presented here provide the first direct assessment of the impact of different sanitation procedures on the subway microbiome, allowing a better ...
Keywords	Subway microbiome ; Probiotic sanitation ; Disinfection ; COVID-19 ; Microbial ecology ; QR100-130
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Monitor for COVID-19 vaccine resistance evolution during clinical trials.

Kennedy, David A / Read, Andrew F

PLoS biology

2020 Volume 18, Issue 11, Page(s) e3001000

Abstract: ... among candidate vaccines and maximizing the potential long-term impact of COVID-19 vaccines. ... can and has evolved. How likely is it that COVID-19 vaccines currently in development will be undermined ... Although less common than the evolution of antimicrobial drug resistance, vaccine resistance ...

Abstract	Although less common than the evolution of antimicrobial drug resistance, vaccine resistance can and has evolved. How likely is it that COVID-19 vaccines currently in development will be undermined by viral evolution? We argue that this can be determined by repurposing samples that are already being collected as part of clinical trials. Such information would be useful for prioritizing investment among candidate vaccines and maximizing the potential long-term impact of COVID-19 vaccines.
MeSH term(s)	Betacoronavirus/immunology ; COVID-19 ; COVID-19 Vaccines ; Clinical Trials as Topic ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/virology ; Drug Resistance, Viral/immunology ; Humans ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; Risk Factors ; SARS-CoV-2 ; Viral Vaccines/immunology
Chemical Substances	COVID-19 Vaccines ; Viral Vaccines
Keywords	covid19
Language	English
Publishing date	2020-11-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2126776-5
ISSN	1545-7885 ; 1544-9173
ISSN (online)	1545-7885
ISSN	1544-9173
DOI	10.1371/journal.pbio.3001000
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