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  1. Article: Anosmie et COVID-19.

    Reinhard, Antoine / Ikonomidis, Christos / Broome, Martin / Gorostidi, François

    Revue medicale suisse

    2020  Volume 16, Issue N° 691-2, Page(s) 849–851

    Abstract: ... with SARS-CoV-2 responsible for COVID-19. It can be the initial symptom of the disease or remain isolated ... Anosmia associated or not with dysgeusia seems to be a frequent symptom in cases of infection ... pandemic, it seems essential to consider any patient with a new anosmia as being infected with SARS-CoV-2 ...

    Title translation Anosmia and COVID-19.
    Abstract Anosmia associated or not with dysgeusia seems to be a frequent symptom in cases of infection with SARS-CoV-2 responsible for COVID-19. It can be the initial symptom of the disease or remain isolated in pauci-symptomatic patients. Waiting for scientific confirmation and in the context of the current pandemic, it seems essential to consider any patient with a new anosmia as being infected with SARS-CoV-2 until proven otherwise. These patients should therefore isolate themselves and remain alert to the occurrence of other symptoms suggestive of the infection and/or be tested. Topical and systemic corticosteroids and nose washes are contraindicated. The natural course of anosmia seems to be favorable in most cases.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Humans ; Olfaction Disorders/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; SARS-CoV-2
    Keywords covid19
    Language French
    Publishing date 2020-06-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Anosmie et coronavirus

    Frédéric Obringer

    2020  

    Abstract: ... mars : la perte d’odorat (ou anosmie) peut figurer au nombre des premiers symptômes du Covid-19 ...

    Abstract "Le directeur général de la santé, Jérôme Salomon, l’a déclaré dans son compte-rendu du vendredi 20 mars : la perte d’odorat (ou anosmie) peut figurer au nombre des premiers symptômes du Covid-19. Négligé depuis l’irruption de la maladie, ce signe clinique est désormais relevé dans de nombreux pays et pourrait être expliqué par la capacité du nouveau coronavirus à infecter le système nerveux central des malades – notamment les zones du cerveau traitant les informations olfactives. Cette hypot.
    Keywords covid19
    Publishing date 2020-04-03T21:12:27Z
    Publisher Parfums en Chine
    Publishing country fr
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Can't smell the virus: SARS-CoV-2, chromatin organization, and anosmia.

    Sorek, Matan / Meshorer, Eran

    Developmental cell

    2022  Volume 57, Issue 9, Page(s) 1081–1082

    Abstract: ... but the underlying mechanism remains obscure. In a recent Cell study, Zazhytska et al. (2022) report non-cell ... Anosmia, or loss of smell, is strongly associated with SARS-CoV-2 infection in humans ...

    Abstract Anosmia, or loss of smell, is strongly associated with SARS-CoV-2 infection in humans, but the underlying mechanism remains obscure. In a recent Cell study, Zazhytska et al. (2022) report non-cell-autonomous disruption of long-range genomic interactions of olfactory receptor genes in response to SARS-CoV-2 infection, and these interactions remain disrupted long after virus clearance.
    MeSH term(s) Anosmia ; COVID-19 ; Chromatin/genetics ; Humans ; SARS-CoV-2/genetics ; Smell
    Chemical Substances Chromatin
    Language English
    Publishing date 2022-05-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2022.04.015
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  4. Article ; Online: Early recovery following new onset anosmia during the COVID-19 pandemic - an observational cohort study.

    Hopkins, Claire / Surda, Pavol / Whitehead, Emily / Kumar, B Nirmal

    Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale

    2020  Volume 49, Issue 1, Page(s) 26

    Abstract: ... symptoms in COVID-19 infection. As yet there are no reports on duration and recovery rates. We set out ... to characterise patients reporting new onset smell and taste disturbance during the COVID-19 pandemic and report ... and taste disturbance during the COVID-19 pandemic, with 1 week follow-up.: Results: Three hundred ...

    Abstract Background: A rapidly evolving evidence suggests that smell and taste disturbance are common symptoms in COVID-19 infection. As yet there are no reports on duration and recovery rates. We set out to characterise patients reporting new onset smell and taste disturbance during the COVID-19 pandemic and report on early recovery rates.
    Methods: Online Survey of patients reporting self-diagnosed new onset smell and taste disturbance during the COVID-19 pandemic, with 1 week follow-up.
    Results: Three hundred eighty-two patents completed bot an initial and follow-up survey. 86.4% reported complete anosmia and a further 11.5% a very severe loss of smell at the time of completing the first survey. At follow-up 1 week later, there is already significant improvement in self-rating of severity of olfactory loss. 80.1% report lower severity scores at follow-up, 17.6% are unchanged and 1.9% are worse. 11.5% already report compete resolution at follow up, while 17.3% report persistent complete loss of smell, with reported duration being 1 to over 4 weeks. This is reflected in the overall cumulative improvement rate of 79% patients overall in the interval between surveys.
    Conclusions: A review of the growing evidence base supports the likelihood that out cohort have suffered olfactory loss as part of COVID-19 infection. While early recovery rates are encouraging, long term rates will need to be further investigated and there may be an increase in patients with persistent post-viral loss as a result of the pandemic. We further call for loss of sense of smell to be formerly recognised as a marker of COVID-19 infection.
    MeSH term(s) Adolescent ; Adult ; Aged ; Betacoronavirus ; COVID-19 ; Cohort Studies ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Olfaction Disorders/epidemiology ; Olfaction Disorders/etiology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Smell ; Surveys and Questionnaires ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-05-04
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2434004-2
    ISSN 1916-0216 ; 1916-0208 ; 0381-6605
    ISSN (online) 1916-0216
    ISSN 1916-0208 ; 0381-6605
    DOI 10.1186/s40463-020-00423-8
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  5. Article ; Online: Lugte- og smagstab som primære symptom på COVID-19 ; Anosmia and ageusia as primary symptoms of COVID-19

    Haldrup, Mette / Johansen, Mikkel Illemann / Fjaeldstad, Alexander Wieck

    Haldrup , M , Johansen , M I & Fjaeldstad , A W 2020 , ' Lugte- og smagstab som primære symptom på COVID-19 ' , Ugeskift for Læger , bind 182 , nr. 18 , V04200205 .

    2020  

    Abstract: ... with subjective anosmia and ageusia as the major presenting symptoms of COVID-19. Apart from a week of slightly ... COVID-19 forårsaget af severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), spænder fra milde ... 19. Forbindelsen mellem COVID-19 og lugte-/smagstab er dog endnu ikke verificeret med testning af ...

    Abstract Coronavirus har den forgangne måned fået et altoverskyggende sundhedsfagligt fokus. Den potentielt dødelige virus har skabt vidtrækkende konsekvenser, hvor der gøres en lang række foranstaltninger for at reducere smittespredning. Nøglen i denne indsats er at identificere smittede personer. For at denne indsats har effekt er det essentielt at genkende symptomer på smitte. De beskrevne symptomer på sygdommen COVID-19 forårsaget af severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), spænder fra milde til svære tilfælde. De hyppigste symptomer er feber, hoste, muskelsmerter og træthed. Sjældnere symptomer er åndenød, hovedpine, diarré, hæmoptyse, rinitis og uproduktiv hoste. Der har desuden været beskrivelser fra flere lande, hvor læger har observeret tilfælde af lugte- og smagstab i forbindelse med COVID-19. Forbindelsen mellem COVID-19 og lugte-/smagstab er dog endnu ikke verificeret med testning af sanserne. Vi præsenterer en sygehistorie med en SARS-CoV-2 positiv patient med monosymptomatisk tabt lugtesans og reduceret smagssans som eneste symptomer ud over meget let løbenæse hos en ellers fuldstændig rask læge i starten af 30’erne.

    This case report describes a physician in the early 30ies with subjective anosmia and ageusia as the major presenting symptoms of COVID-19. Apart from a week of slightly runny nose when coming from cold to warm air, the only symptom was a sudden onset of persistent anosmia and ageusia. Two weeks after normalisation of the mild sino-nasal symptoms, the patient was tested positive for SARS-CoV-2, and anosmia was verified with Sniffin' Sticks tests. Hypogeusia was verified with taste screening and two validated taste tests. Olfactory and gustatory loss may be underestimated symptoms of COVID-19.
    Keywords Lugtesans ; Smagssans ; Olfaktion ; COVID-19 ; Lugtetab ; Smagstab ; covid19
    Language Danish
    Publishing country dk
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Age-dependent appearance of SARS-CoV-2 entry sites in mouse chemosensory systems reflects COVID-19 anosmia-ageusia symptoms

    Julien Brechbühl / Ana Catarina Lopes / Dean Wood / Sofiane Bouteiller / Aurélie de Vallière / Chantal Verdumo / Marie-Christine Broillet

    Communications Biology, Vol 4, Iss 1, Pp 1-

    2021  Volume 12

    Abstract: Brechbühl et al characterise the gene and protein expression of ACE2/TMPRSS2 in the mouse olfactory ...

    Abstract Brechbühl et al characterise the gene and protein expression of ACE2/TMPRSS2 in the mouse olfactory and gustatory cells, which reveals that SARS-CoV-2 target cells are of basal and sensory origin. They also demonstrate an age-dependent appearance of viral entry-sites, which could inform the use of mouse models in the investigation of SARS-CoV-2 effects on olfaction.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
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