Article ; Online: Styrax blocks inward and outward current of Kir2.1 channel.
Channels (Austin, Tex.)
2017 Volume 11, Issue 1, Page(s) 46–54
Abstract: ... the currents of Kir2.1. Here, we identified a novel blocker of Kir2.1, styrax, which is a kind of natural ... outward currents of Kir2.1. The IC ... compound selected from traditional Chinese medicine. Our data show that styrax can abolish the inward and ...
| Abstract | Kir2.1 plays key roles in setting rest membrane potential and modulation of cell excitability. Mutations of Kir2.1, such as D172N or E299V, inducing gain-of-function, can cause type3 short QT syndrome (SQT3) due to the enlarged outward currents. So far, there is no clinical drug target to block the currents of Kir2.1. Here, we identified a novel blocker of Kir2.1, styrax, which is a kind of natural compound selected from traditional Chinese medicine. Our data show that styrax can abolish the inward and outward currents of Kir2.1. The IC |
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| MeSH term(s) | HEK293 Cells ; Humans ; Medicine, Chinese Traditional ; Plant Preparations/pharmacology ; Potassium Channel Blockers/pharmacology ; Potassium Channels, Inwardly Rectifying/antagonists & inhibitors ; Potassium Channels, Inwardly Rectifying/physiology ; Styrax |
| Chemical Substances | Kir2.1 channel ; Plant Preparations ; Potassium Channel Blockers ; Potassium Channels, Inwardly Rectifying |
| Language | English |
| Publishing date | 2017-01-02 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 1933-6969 |
| ISSN (online) | 1933-6969 |
| DOI | 10.1080/19336950.2016.1207022 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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