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  1. Article ; Online: Infection Mechanism of SARS-COV-2 and Its Implication on the Nervous System.

    Reza-Zaldívar, Edwin Estefan / Hernández-Sapiéns, Mercedes Azucena / Minjarez, Benito / Gómez-Pinedo, Ulises / Márquez-Aguirre, Ana Laura / Mateos-Díaz, Juan Carlos / Matias-Guiu, Jorge / Canales-Aguirre, Alejandro Arturo

    Frontiers in immunology

    2021  Volume 11, Page(s) 621735

    Abstract: ... may also be applicable for SARS-CoV-2. Understanding the underlying pathogenetic mechanisms in the nervous ... complications following SARS-CoV-2 infection include confusion, cerebrovascular diseases, ataxia, hypogeusia ... peripheral nerve terminals and its neurological implications in the central nervous system. ...

    Abstract In late December 2019, multiple atypical pneumonia cases resulted in severe acute respiratory syndrome caused by a pathogen identified as a novel coronavirus SARS-CoV-2. The most common coronavirus disease 2019 (COVID-19) symptoms are pneumonia, fever, dry cough, and fatigue. However, some neurological complications following SARS-CoV-2 infection include confusion, cerebrovascular diseases, ataxia, hypogeusia, hyposmia, neuralgia, and seizures. Indeed, a growing literature demonstrates that neurotropism is a common feature of coronaviruses; therefore, the infection mechanisms already described in other coronaviruses may also be applicable for SARS-CoV-2. Understanding the underlying pathogenetic mechanisms in the nervous system infection and the neurological involvement is essential to assess possible long-term neurological alteration of COVID-19. Here, we provide an overview of associated literature regarding possible routes of COVID-19 neuroinvasion, such as the trans-synapse-connected route in the olfactory pathway and peripheral nerve terminals and its neurological implications in the central nervous system.
    MeSH term(s) Animals ; COVID-19/virology ; Humans ; Nervous System/virology ; SARS-CoV-2/pathogenicity
    Language English
    Publishing date 2021-01-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.621735
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Crosstalk between SARS-CoV-2 Infection and Neurological Disorders: A Review.

    Azhar, Asim / Wali, Mohammad Akram / Rashid, Qudsia / Khan, Wajihul Hasan / Al-Hosaini, Khaled / Owais, Mohammad / Kamal, Mohammad Amjad

    CNS & neurological disorders drug targets

    2022  Volume 22, Issue 5, Page(s) 643–658

    Abstract: ... The neurological implication of SARS-CoV-2 infection is mounting, as substantiated by various reports, and ... in the central nervous system (CNS) is likely. SARS-CoV-2 can enter the nervous system by exploiting the routes ... involved, the array of clinical symptoms, and various nervous system diseases following the attack of SARS ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent responsible for coronavirus disease (COVID-19), is an issue of global concern since March 2020. The respiratory manifestations of COVID-19 have widely been explained in the last couple of months of the pandemic. Initially, the virus was thought to be restricted to the pulmonary system; however, as time progressed and cases increased during the second wave of COVID-19, the virus affected other organs, including the nervous system. The neurological implication of SARS-CoV-2 infection is mounting, as substantiated by various reports, and in the majority of COVID-19 patients with neurological symptoms, the penetration of SARS-CoV-2 in the central nervous system (CNS) is likely. SARS-CoV-2 can enter the nervous system by exploiting the routes of olfactory mucosa, olfactory and sensory nerve endings, or endothelial and nerve tissues, thus crossing the neural-mucosal interface in the olfactory mucosa in the nose. Owing to multifactorial and complex pathogenic mechanisms, COVID-19 adds a large-scale risk to the entire nervous system. A thorough understanding of SARSCoV- 2 neurological damage is still vague; however, our comprehension of the virus is rapidly developing. The present comprehensive review will gain insights and provide neurological dimensions of COVID-19 and their associated anomalies. The review presents the entry routes of SARS-CoV-2 into the CNS to ascertain potential targets in the tissues owing to infection. We also discuss the molecular mechanisms involved, the array of clinical symptoms, and various nervous system diseases following the attack of SARS-CoV-2.
    MeSH term(s) Humans ; COVID-19/complications ; SARS-CoV-2 ; Nervous System Diseases ; Central Nervous System ; Pandemics
    Language English
    Publishing date 2022-04-19
    Publishing country United Arab Emirates
    Document type Review ; Journal Article
    ZDB-ID 2228394-8
    ISSN 1996-3181 ; 1871-5273
    ISSN (online) 1996-3181
    ISSN 1871-5273
    DOI 10.2174/1871527321666220418114009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5892: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Microglial Implications in SARS-CoV-2 Infection and COVID-19: Lessons From Viral RNA Neurotropism and Possible Relevance to Parkinson's Disease.

    Awogbindin, Ifeoluwa O / Ben-Azu, Benneth / Olusola, Babatunde A / Akinluyi, Elizabeth T / Adeniyi, Philip A / Di Paolo, Therese / Tremblay, Marie-Ève

    Frontiers in cellular neuroscience

    2021  Volume 15, Page(s) 670298

    Abstract: ... to the neurons, glial cells, and/or brain vasculature in response to SARS-CoV-2 infection or COVID-19 ... neuroinfections, especially those with a similar genetic composition and route of entry as SARS-CoV-2 ... of RNA viruses and SARS-CoV-2 vis-à-vis the microglial means of viral recognition. Responses of microglia ...

    Abstract Since December 2019, humankind has been experiencing a ravaging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak, the second coronavirus pandemic in a decade after the Middle East respiratory syndrome coronavirus (MERS-CoV) disease in 2012. Infection with SARS-CoV-2 results in Coronavirus disease 2019 (COVID-19), which is responsible for over 3.1 million deaths worldwide. With the emergence of a second and a third wave of infection across the globe, and the rising record of multiple reinfections and relapses, SARS-CoV-2 infection shows no sign of abating. In addition, it is now evident that SARS-CoV-2 infection presents with neurological symptoms that include early hyposmia, ischemic stroke, meningitis, delirium and falls, even after viral clearance. This may suggest chronic or permanent changes to the neurons, glial cells, and/or brain vasculature in response to SARS-CoV-2 infection or COVID-19. Within the central nervous system (CNS), microglia act as the central housekeepers against altered homeostatic states, including during viral neurotropic infections. In this review, we highlight microglial responses to viral neuroinfections, especially those with a similar genetic composition and route of entry as SARS-CoV-2. As the primary sensor of viral infection in the CNS, we describe the pathogenic and neuroinvasive mechanisms of RNA viruses and SARS-CoV-2 vis-à-vis the microglial means of viral recognition. Responses of microglia which may culminate in viral clearance or immunopathology are also covered. Lastly, we further discuss the implication of SARS-CoV-2 CNS invasion on microglial plasticity and associated long-term neurodegeneration. As such, this review provides insight into some of the mechanisms by which microglia could contribute to the pathophysiology of post-COVID-19 neurological sequelae and disorders, including Parkinson's disease, which could be pervasive in the coming years given the growing numbers of infected and re-infected individuals globally.
    Language English
    Publishing date 2021-06-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2021.670298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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