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  1. Artikel ; Online: Multisystem inflammatory syndrome in children related to COVID-19: A New York City experience.

    Riollano-Cruz, Mariawy / Akkoyun, Esra / Briceno-Brito, Eudys / Kowalsky, Shanna / Reed, James / Posada, Roberto / Sordillo, Emilia Mia / Tosi, Michael / Trachtman, Rebecca / Paniz-Mondolfi, Alberto

    Journal of medical virology

    2020  Band 93, Heft 1, Seite(n) 424–433

    Abstract: ... with the multi-systeminflammatory syndrome in children (MIS-C), temporally related to COVID-19, who presented ... for severe COVID-19. However, reports have emerged recently of cases of COVID-19 in children with a systemic ... for care to a tertiary pediatric referral center in New York City. We discuss the disproportionate burden of disease ...

    Abstract In December 2019, the 2019, a novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) first emerged in Wuhan, China. This has now spread worldwide and was declared a pandemic by March 2020. Initially, the pediatric population was described as a low risk for severe COVID-19. However, reports have emerged recently of cases of COVID-19 in children with a systemic inflammatory disease, with features that overlap with Kawasaki disease (KD). We describe the first 15 cases with the multi-systeminflammatory syndrome in children (MIS-C), temporally related to COVID-19, who presented for care to a tertiary pediatric referral center in New York City. We discuss the disproportionate burden of disease among Hispanic/Latino and Black/African American ancestry, the distinct cytokine signature across the disease spectrum (IL-1/IL-6), and the potential role and pathogenesis of SARS-CoV-2 in this new clinical entity.
    Mesh-Begriff(e) Adolescent ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/immunology ; Child ; Child, Preschool ; Cytokines/immunology ; Female ; Humans ; Male ; New York City/epidemiology ; Retrospective Studies ; Systemic Inflammatory Response Syndrome/epidemiology ; Tertiary Care Centers ; Young Adult
    Chemische Substanzen Cytokines
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-10-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26224
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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  2. Artikel: Multisystem inflammatory syndrome in children related to COVID-19: A New York City experience

    Riollano-Cruz, Mariawy / Akkoyun, Esra / Briceno-Brito, Eudys / Kowalsky, Shanna / Reed, James / Posada, Roberto / Sordillo, Emilia Mia / Tosi, Michael / Trachtman, Rebecca / Paniz-Mondolfi, Alberto

    J. med. virol

    Abstract: ... with the multi-systeminflammatory syndrome in children (MIS-C), temporally related to COVID-19, who presented ... for severe COVID-19. However, reports have emerged recently of cases of COVID-19 in children with a systemic ... for care to a tertiary pediatric referral center in New York City. We discuss the disproportionate burden of disease ...

    Abstract In December 2019, the 2019, a novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) first emerged in Wuhan, China. This has now spread worldwide and was declared a pandemic by March 2020. Initially, the pediatric population was described as a low risk for severe COVID-19. However, reports have emerged recently of cases of COVID-19 in children with a systemic inflammatory disease, with features that overlap with Kawasaki disease (KD). We describe the first 15 cases with the multi-systeminflammatory syndrome in children (MIS-C), temporally related to COVID-19, who presented for care to a tertiary pediatric referral center in New York City. We discuss the disproportionate burden of disease among Hispanic/Latino and Black/African American ancestry, the distinct cytokine signature across the disease spectrum (IL-1/IL-6), and the potential role and pathogenesis of SARS-CoV-2 in this new clinical entity.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #613951
    Datenquelle COVID19

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  3. Artikel ; Online: Multisystem Inflammatory Syndrome in Children (MIS‐C) Related to COVID‐19

    Riollano‐Cruz, Mariawy / Akkoyun, Esra / Briceno‐Brito, Eudys / Kowalsky, Shanna / Posada, Roberto / Sordillo, Emilia Mia / Tosi, Michael / Trachtman, Rebecca / Paniz‐Mondolfi, Alberto

    Journal of Medical Virology ; ISSN 0146-6615 1096-9071

    A New York City Experience

    2020  

    Schlagwörter Virology ; Infectious Diseases ; covid19
    Sprache Englisch
    Verlag Wiley
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    DOI 10.1002/jmv.26224
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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  4. Artikel: Multisystem Inflammatory Syndrome in Children Associated With Coronavirus Disease 2019 in a Children's Hospital in New York City: Patient Characteristics and an Institutional Protocol for Evaluation, Management, and Follow-Up.

    Jonat, Brian / Gorelik, Mark / Boneparth, Alexis / Geneslaw, Andrew S / Zachariah, Philip / Shah, Amee / Broglie, Larisa / Duran, Juan / Morel, Kimberly D / Zorrilla, Maria / Svoboda, Leanne / Johnson, Candace / Cheng, Jennifer / Garzon, Maria C / Silver, Wendy G / Gross Margolis, Kara / Neunert, Cindy / Lytrivi, Irene / Milner, Joshua /
    Kernie, Steven G / Cheung, Eva W

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

    2020  Band 22, Heft 3, Seite(n) e178–e191

    Abstract: ... on relevant literature related to coronavirus disease 2019, multisystem inflammatory syndrome in children, and ... related inflammatory syndromes, as well as our experience caring for children with multisystem ... related to coronavirus disease 2019 known as multisystem inflammatory syndrome in children. It is based ...

    Abstract Objectives: The disease caused by severe acute respiratory syndrome coronavirus 2, known as coronavirus disease 2019, has resulted in a global pandemic. Reports are emerging of a new severe hyperinflammatory syndrome related to coronavirus disease 2019 in children and adolescents. The Centers for Disease Control and Prevention has designated this disease multisystem inflammatory syndrome in children. Our objective was to develop a clinical inpatient protocol for the evaluation, management, and follow-up of patients with this syndrome.
    Data sources: The protocol was developed by a multidisciplinary team based on relevant literature related to coronavirus disease 2019, multisystem inflammatory syndrome in children, and related inflammatory syndromes, as well as our experience caring for children with multisystem inflammatory syndrome in children. Data were obtained on patients with multisystem inflammatory syndrome in children at our institution from the pre-protocol and post-protocol periods.
    Data synthesis: Our protocol was developed in order to identify cases of multisystem inflammatory syndrome in children with high sensitivity, stratify risk to guide treatment, recognize co-infectious or co-inflammatory processes, mitigate coronary artery abnormalities, and manage hyperinflammatory shock. Key elements of evaluation include case identification using broad clinical characteristics and comprehensive laboratory and imaging investigations. Treatment centers around glucocorticoids and IV immunoglobulin with biologic immunomodulators as adjuncts. Multidisciplinary follow-up after discharge is indicated to manage continued outpatient therapy and evaluate for disease sequelae. In nearly 2 months, we admitted 54 patients with multisystem inflammatory syndrome in children, all of whom survived without the need for invasive ventilatory or mechanical circulatory support. After institution of this protocol, patients received earlier treatment and had shorter lengths of hospital stay.
    Conclusions: This report provides guidance to clinicians on evaluation, management, and follow-up of patients with a novel hyperinflammatory syndrome related to coronavirus disease 2019 known as multisystem inflammatory syndrome in children. It is based on the relevant literature and our experience. Instituting such a protocol during a global pandemic is feasible and is associated with patients receiving treatment and returning home more quickly.
    Mesh-Begriff(e) Adolescent ; COVID-19 ; Child ; Follow-Up Studies ; Humans ; New York City ; SARS-CoV-2 ; Syndrome ; Systemic Inflammatory Response Syndrome
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-10-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2052349-X
    ISSN 1947-3893 ; 1529-7535
    ISSN (online) 1947-3893
    ISSN 1529-7535
    DOI 10.1097/PCC.0000000000002598
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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