Article ; Online: Detection of SARS-CoV-2 RNA in serum is associated with increased mortality risk in hospitalized COVID-19 patients.
2021 Volume 11, Issue 1, Page(s) 13134
Abstract: ... at risk of poor outcomes is critical. Our objective was to analyse SARS-CoV-2 RNA detection in serum ... 19. Detection of SARS-CoV-2 RNA in serum (viremia) was performed with samples collected at 48-72 h ... mortality and need for ICU admission during hospitalization for COVID-19. Viremia was detected in 50-60 ...
| Abstract | COVID-19 has overloaded national health services worldwide. Thus, early identification of patients at risk of poor outcomes is critical. Our objective was to analyse SARS-CoV-2 RNA detection in serum as a severity biomarker in COVID-19. Retrospective observational study including 193 patients admitted for COVID-19. Detection of SARS-CoV-2 RNA in serum (viremia) was performed with samples collected at 48-72 h of admission by two techniques from Roche and Thermo Fischer Scientific (TFS). Main outcome variables were mortality and need for ICU admission during hospitalization for COVID-19. Viremia was detected in 50-60% of patients depending on technique. The correlation of Ct in serum between both techniques was good (intraclass correlation coefficient: 0.612; p < 0.001). Patients with viremia were older (p = 0.006), had poorer baseline oxygenation (PaO |
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| MeSH term(s) | Aged ; Biomarkers/blood ; COVID-19/blood ; COVID-19/mortality ; COVID-19/virology ; Critical Care ; Female ; Hospitalization ; Humans ; Interleukin-6/blood ; Male ; Middle Aged ; Patient Acuity ; RNA, Viral/blood ; Real-Time Polymerase Chain Reaction ; Retrospective Studies ; Risk Factors ; SARS-CoV-2/genetics ; Spain ; Viremia/blood ; Viremia/virology |
| Chemical Substances | Biomarkers ; Interleukin-6 ; RNA, Viral |
| Language | English |
| Publishing date | 2021-06-23 |
| Publishing country | England |
| Document type | Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2615211-3 |
| ISSN | 2045-2322 ; 2045-2322 |
| ISSN (online) | 2045-2322 |
| ISSN | 2045-2322 |
| DOI | 10.1038/s41598-021-92497-1 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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