Article: Severe liver dysfunction complicating course of COVID-19 in the critically ill: multifactorial cause or direct viral effect?
2021 Volume 11, Issue 1, Page(s) 44
Abstract: ... on severe liver dysfunction (SLD) in critically ill with COVID-19 are lacking. We evaluated the occurrence ... clinical characteristics and outcome of SLD in critically ill patients with COVID-19.: Methods: Clinical ... Conclusion: One-third of critically ill patients with COVID-19 suffer from SLD, which is associated ...
| Abstract | Background: SARS-CoV-2 caused a pandemic and global threat for human health. Presence of liver injury was commonly reported in patients with coronavirus disease 2019 (COVID-19). However, reports on severe liver dysfunction (SLD) in critically ill with COVID-19 are lacking. We evaluated the occurrence, clinical characteristics and outcome of SLD in critically ill patients with COVID-19. Methods: Clinical course and laboratory was analyzed from all patients with confirmed COVID-19 admitted to ICU of the university hospital. SLD was defined as: bilirubin ≥ 2 mg/dl or elevation of aminotransferase levels (> 20-fold ULN). Results: 72 critically ill patients were identified, 22 (31%) patients developed SLD. Presenting characteristics including age, gender, comorbidities as well as clinical presentation regarding COVID-19 overlapped substantially in both groups. Patients with SLD had more severe respiratory failure (paO Conclusion: One-third of critically ill patients with COVID-19 suffer from SLD, which is associated with high mortality. Occurrence of viremia and severity of illness seem to contribute to occurrence of SLD and underline the multifactorial cause. |
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| Language | English |
| Publishing date | 2021-03-15 |
| Publishing country | Germany |
| Document type | Journal Article |
| ZDB-ID | 2617094-2 |
| ISSN | 2110-5820 |
| ISSN | 2110-5820 |
| DOI | 10.1186/s13613-021-00835-3 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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